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Thymosin alpha 162304-98-7 API

Name: Thymosin alpha 162304-98-7 API
Brand: orient
Price: 33 USD
Availability: InStock

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Unit Price:

$33-35/UNIT FOB

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CAS No.:

62304-98-7

Grade:

Industrial Grade

Content:

99%

Port:

shanghai

Brand:

orient

Packaging:

1KG, 5KG, 25KG

Price valid (until):

2026-06-09

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Qingdao Orient Chemical Co.,LTD

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Trader

Location:

China

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pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
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Inquiry History

Description

Thymosin α1 Basic information

Description Background

Product Name:	Thymosin α1
Synonyms:	THYMOSIN ALPHA1 BOVINE;THYMOSIN APHA 1;ZADAXIN;Thymosin αAcetate salt;Thymalfasin Acetate salt;Thymosin α 1 Acetate(Thymalfasin);thymosin α1 bovine;AC-SER-ASP-ALA-ALA-VAL-ASP-THR-SER-SER-GLU-ILE-THR-THR-LYS-ASP-LEU-LYS-GLU-LYS-LYS-GLU-VAL-VAL-GLU-GLU-ALA-GLU-ASN: AC-SDAAVDTSSEITTKDLKEKKEVVEEAEN
CAS:	62304-98-7
MF:	C129H215N33O55
MW:	3108.28
EINECS:	1592732-453-0
Product Categories:	Amino Acid Derivatives;Peptide;Various Peptides;62304-98-7
Mol File:	62304-98-7.mol

Thymosin α1 Chemical Properties

Boiling point	2899.7±65.0 °C(Predicted)
density	1.360±0.06 g/cm3(Predicted)
storage temp.	−20°C
solubility	It is recommended to reconstitute the lyophilized Thymosin a1 in sterile 18MΩ-cm H2O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.
form	A crystalline solid
color	Sterile Filtered White lyophilized (freeze-dried) powder.
Sequence	Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH
Stability:	Lyophilized Thymosin a1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Thymalfasin should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Cosmetics Ingredients Functions	HAIR CONDITIONING
InChIKey	NZVYCXVTEHPMHE-WTRFZTBJNA-N

Safety Information

WGK Germany

MSDS Information

Provider	Language
SigmaAldrich	English

Thymosin α1 Usage And Synthesis

Description	Thymosin-α1 (T-α1), a synthetic 28-amino acid peptide with multiple biological activities primarily directed towards immune response enhancement, this drug is used for the treatment of HBV and hepatitis C virus (HCV) infections, and being developed for the treatment of non-small cell lung cancer (NSCLC), hepatocellular carcinoma, AIDS and malignant melanoma. T-α1 is able to potentiate the action of cytokines and also reduce the hematological toxicity of cytotoxic drug therapy, such as cyclophosphamide, 5-fluorouracil, dacarbazine.
Description	Thymosin α1 is an immunomodulator peptide formed from the cleavage of prothymosin α. Thymosin α1 inhibits the growth of 5TGM1 mouse and OPM-2, LP-1, and U266 human multiple myeloma cells in vitro but not in vivo. It also increases CD3- and CD28-induced T cell proliferation in C57BL/KaLwRij splenocytes but not in allogeneic mixed lymphocyte reactions using C57BL/KaLwRij and BALB/c splenocyte co-cultures when used at a concentration of 20 μM. Thymosin α1 also inhibits the growth and migration of H1299, NL9980, and L9981 non-small cell lung cancer (NSCLC) cells that express high levels of programmed cell death ligand 1 (PD-L1) but not of A549 and SPC-A-1 NSCLC cells that express low PD-L1 levels. It also decreases the number of metastatic lesions in a L9981, but not an A549, NSCLC mouse xenograft model when administered at a dose of 20 mg/kg per day. Thymosin α1 (200 μg/kg) increases indoleamine 2,3-dioxygenase 1 (IDO1) expression and IL-10 levels and decreases IL-1β and TNF-α production in the lung in a p.Phe508del mutant cystic fibrosis transmembrane conductance regulator (CFTR^{F508del/F508del} ) mouse model of cystic fibrosis and chronic A. fumigatus infection.
Uses	Zadax-in (SciClone). Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying, enhancing, and restoring immune function. Immune enhancing peptide Helps prevent infections such as the common cold or the flu and diseases Reduces inflammation in the body Aids in the removal of acute or chronic infections Has antibacterial, antiviral, and antifungal properties Supports the eradication of unhealthy cells Protects your cells against oxidative stress and damage Inhibits viral replication Improve symptoms associated with chronic fatigue Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies, as an enhancer of vaccine response, and as a means of curbing morbidity and mortality in sepsis and numerous infections. https://www.ncbi.nlm.nih.gov
Definition	ChEBI: Thymalfasin is a polypeptide.
Biological Functions	Thymalfasin is a synthetic analogue of thymosin-alpha-1, a 28-amino acid protein derived from the precursor protein prothymosin-alpha. Exhibiting a variety of immunoregulating properties, thymosin-alpha-1 induces differentiation of murine T-cell precursors and human thymocytes and the terminal differentiation of functionally immature cord blood lymphocytes and induces production of IL-2, high affinity IL-2 receptors, and B-cell growth factors by peripheral blood mononuclear cells. T-helper and cytotoxic/suppressor T-cell populations are targets of thymosin activity. Thymosin-alpha-1 has been shown to increase the efficiency of antigen presentation by macrophages and to be an endogenous modulator of alpha-thrombin activity. https://www.prospecbio.com
Synthesis Reference(s)	Thymosin α1 (Tα1), a 28-amino acid Nα-acetylated peptide, has a powerful general immunostimulating activity. Although biosynthesis is an attractive means of large-scale manufacture, to date, Tα1 can only be chemosynthesized because of two obstacles to its biosynthesis: the difficulties in expressing small peptides and obtaining Nα-acetylation. In this study, we describe a novel production process for Nα-acetylated Tα1 in Escherichia coli. Synthesis of Thymosin α1, a Polypeptide of the Thymus Production of Nα-acetylated thymosin α1 in Escherichia coli Synthesis of thymosin .alpha.1
Clinical claims and research	Thymosin α1 (Tα1) is a 28 amino acid peptide produced by thymic epithelial cellslocated in the outer cortex and medulla of the thymus (Hirokawa et al., 1982).Invitro studies involving the use of bone marrow and progenitor cell cocultures haverevealed Tα1's capacity to stimulate thymocyte maturation (Knutsen et al.,1999).Inaddition，the administration of Tα1 in mice has resulted in notable increases inmurine thymic size and thymocyte numbers，further demonstrating Tal's abilityto enhance thymocyte growth (Beuth et al., 2000).Tα1 is likely to exert its stimula-tory effect on developing thymocytes partly by acting as an anti-apoptotic agent(Baumann et al.，1996). Interestingly，the addition of Tα1 to thymocyte andthymic epithelial cell cocultures was found to increase the production of IL-7 byepithelial cells, suggesting that the enhancing effect of Tal on thymopoiesis may bethrough the induction of IL-7 (Knutsen et al.，1999). Basic Biology and Clinical Impact of Immunosenescence
Description	Thymosin a₁ acetate, also known as thymalfasin has immunoregulatory properties enhancing immune functions. Thymosin a₁ has a molecular formula of C₁₂₉H₂₁₅N₃₃O₅₅ a.a. sequence of Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH and having a Mw of 3108.32 Dalton.
Background	Thymalfasin is a synthetic analogue of thymosin-alpha-1, a 28-amino acid protein derived from the precursor protein prothymosin-alpha. Exhibiting a variety of immunoregulating properties, thymosin-alpha-1 induces differentiation of murine T-cell precursors and human thymocytes and the terminal differentiation of functionally immature cord blood lymphocytes and induces production of IL-2, high affinity IL-2 receptors, and B-cell growth factors by peripheral blood mononuclear cells. T-helper and cytotoxic/suppressor T-cell populations are targets of thymosin activity. Thymosin-alpha-1 has been shown to increase the efficiency of antigen presentation by macrophages and to be an endogenous modulator of alpha-thrombin activity.
References	[1] RICHARD E. MANROW. The human prothymosin α gene family contains several processed pseudogenes lacking deleterious lesions[J]. Genomics, 1992, 13 2: Pages 319-331. DOI: 10.1016/0888-7543(92)90248-q [2] MARILèNE BINSFELD. Impact of the immunomodulating peptide thymosin alpha 1 on multiple myeloma and immune recovery after hematopoietic stem cell transplantation.[J]. Cancer Immunology, Immunotherapy, 2015, 64 8: 989-998. DOI: 10.1007/s00262-015-1708-2 [3] CONG BO. Thymosin α1 suppresses migration and invasion of PD-L1 high-expressing non-small-cell lung cancer cells via inhibition of STAT3-MMP2 signaling.[J]. OncoTargets and therapy, 2018: 7255-7270. DOI: 10.2147/ott.s177943 [4] LUIGINA ROMANI. Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis[J]. Nature Medicine, 2017, 23 5: 590-600. DOI: 10.1038/nm.4305

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Basic Info

Product Name:

Thymosin alpha 1

Other Name:

Thymosin α1 Acetate;Thymosin α 1 Acetate(Thymalfasin);Thymosina1Acetate;thymosin α1 bovine;Thymosinα1 bovine,Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn;ThyMosins alpha 1;Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH acetate salt;Thymosin α1, Thymalfasin

CAS No.:

62304-98-7

Molecular Formula:

C129H215N33O55

InChIKeys:

NZVYCXVTEHPMHE-ZSUJOUNUSA-N

Molecular Weight:

3108.28

Exact Mass:

3106.504150

EC Number:

1592732-453-0

UNII:

W0B22ISQ1C

DSSTox ID:

DTXSID80211374

NCI Thesaurus Code:

C1253

Categories:

Drugs Influencing Immune Function

Characteristics

PSA:

1460

XLogP3:

-9.87

Appearance:

White powder

Density:

1.4±0.1 g/cm3

Boiling Point:

2899.7±65.0 °C at 760 mmHg

Flash Point:

1707.5±34.3 °C

Refractive Index:

1.563

Storage Conditions:

−20°C

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Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Thymosin alpha 1 Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

14 Inquiries

Country	Product	Purchase Quantity	Date Posted
Bulgaria	High Purity Thymosin Alpha-1 Peptide CAS 62304-98-7 Thymosin Alpha 1	50	Oct 13, 2023
United States	Peptide Therapy to Optimize Healing Bpc Thymosin Beta Thymosin Alpha USA Wholesales CAS: 62304-98-7	50 G	Jul 5, 2023
Canada	Thymosin Alpha 1	1 KG	May 6, 2026
United States	Thymosin Alpha-1	1 MT	Mar 10, 2026
Croatia	Thymosin alfa 1	1 KG	Jan 7, 2026
United Kingdom	Thymosin Alpha-1	10 PCS	Jan 3, 2026
United States	Thymalfasin - Thymosin Alpha-1	100 MG	Jul 10, 2025
United States	Thymosin Alpha-1 5 mg	10 MT	Feb 19, 2024
United States	Thymosin alpha 1	10 MG	May 7, 2026
United States	Thymosin Alpha-1	10 MG	Jul 14, 2025
United States	Thymosin alpha 1	1 G	Nov 15, 2024
Bulgaria	Thymosin Alpha 1	10 20' Fcl	Apr 3, 2024
United States	Thymosin Alpha-1	1 G	Jan 27, 2024
United States	IGF-1 LR3 TB500 Thymosin Alpha-1	10 20' Fcl	Feb 16, 2026

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