High Purity Tranexamic Acid Whitening Spot Removing Raw Material

1. Description

Tranexamic Acid is a classic and high-efficiency brightening skincare active ingredient widely used in gentle skin care formulas. It helps balance uneven skin tone and lighten dull complexion caused by external environmental stress. It relieves mild skin sensitivity discomfort, stabilizes fragile skin barrier and maintains long-term skin comfort. It improves rough skin texture, enhances skin clarity and creates a clean and translucent skin condition. Mild in nature, stable in performance and friendly to most skin types, it is widely added into brightening, soothing and repairing skincare products for daily gentle skin maintenance.

2. Application

(1) Hemostatic therapy: Used for hemostasis during and after tooth extraction in patients with hemophilia, as well as for various bleeding conditions caused by excessive fibrinolysis, such as those associated with surgical procedures, acute trauma, postpartum hemorrhage, hemoptysis, and epistaxis.

(2) Treatment of skin conditions: Used to treat various skin conditions such as melasma, post-inflammatory hyperpigmentation, Riehl’s melanosis, acne, rosacea, and angioedema.

(3) Skincare and Cosmetics: Used as a skin-brightening ingredient in skincare products such as serums, masks, and creams to inhibit melanin production and brighten the complexion; widely used in Japanese-style dermocosmetics.

(4) Oral Care Products: Added to toothpaste to help prevent gum bleeding and inflammation, providing anti-inflammatory and hemostatic effects.

3. Main Efficacy

(1) Antifibrinolytic effect: By competitively binding to the lysine binding sites on plasminogen, it prevents the conversion of plasminogen to plasmin, thereby inhibiting the degradation of fibrin clots and exerting a hemostatic effect.

(2) Inhibition of melanin production: By blocking the plasminogen-plasmin system, it interferes with the interaction between melanocytes and keratinocytes, reduces tyrosinase activity, and decreases melanin synthesis. It also achieves skin-brightening and spot-removing effects by activating the cellular autophagy system to downregulate the expression of melanin-synthesizing proteins such as MITF, TRP-1, and TRP-2.

(3) Anti-inflammatory effects: It inhibits the activity of plasmin in UV-induced keratinocytes, reducing the production of inflammatory mediators such as arachidonic acid and prostaglandins. Simultaneously, it suppresses the expression of inflammation-related genes including IL-1α, IL-6, IL-8, and COX-2, thereby improving inflammatory skin conditions such as acne and rosacea.

(4) Anti-angiogenic effects: It inhibits the expression of vascular endothelial growth factor and reduces the number of CD31-positive cells, demonstrating therapeutic effects on skin conditions associated with vascular abnormalities, such as rosacea.

(5) Skin barrier repair: It inhibits the activation of the protease-activated receptor 2 and calcium influx in keratinocytes, thereby improving skin barrier function and providing barrier repair benefits for patients with rosacea.