1. Basic Molecular & Product Parameters (Industry Standard)
Full Name: Cerebrolysin (Neurotrophic Brain-Derived Peptide Complex)
Alias: FPF-1070
CAS Number: 12656-61-0
Composition Standard: A standardized enzymatic hydrolysate from purified porcine brain tissue - ~75%–80% free amino acids
- ~20%–25% low-molecular-weight neuropeptide fragments (all peptide fragments below 10 kDa)
Active Biomimetic Components: Contains fragments analogous to endogenous neurotrophic factors: BDNF, NGF, GDNF, CNTF
Appearance: Sterile lyophilized white powder, vacuum-sealed vial packaging (main specs: 60mg / 215.2mg per vial)
Purity Standard: Batch tested by HPLC for molecular weight distribution & amino acid profiling; full COA, MSDS provided for every shipment
R&D Background: Originally developed in 1949 by Professor Gerhart Harrer (University of Salzburg, Austria). It is a multi-target neuropeptide complex exclusively designed for neuron protection and central nervous system regeneration research.
2. Core Mechanism of Action
Low-molecular peptide fragments of Cerebrolysin can penetrate the blood-brain barrier and regulate multiple neuroprotective signaling pathways to repair damaged neurons:
- Activate Trk receptor cascades (PI3K/Akt & MAPK/ERK), inhibit neuronal apoptosis by upregulating anti-apoptotic Bcl-2 and suppressing caspase-3 / calpain activity;
- Promote neuronal protein synthesis, boost dendritic branching, synaptogenesis and endogenous neurogenesis;
- Suppress neuroinflammation by reducing pro-inflammatory cytokines (IL-1β) and restraining excessive microglial activation;
- Counteract excitotoxicity, oxidative stress and lipid peroxidation in ischemic or traumatized brain tissue;
- Repair tight junction proteins of blood-brain barrier endothelial cells to alleviate vascular leakage after brain injury;
- Optimize cerebral glucose energy metabolism and enhance neuron tolerance to hypoxia.
3. Core Research Applications (For Laboratory Research Only)
Neuroprotection & Brain Injury Repair
Reverse neuronal damage induced by cerebral ischemia, stroke and traumatic brain injury; serve as core reagent for in vitro & in vivo models of ischemic brain lesion, concussion and contusion recovery research.
Anti-Neurodegeneration & Cognitive Research
Regulate amyloid-β metabolism and tau phosphorylation pathways; widely used for preclinical studies on Alzheimer’s senile dementia, vascular dementia and age-related cognitive decline.
Neural Plasticity & Memory Modulation
Stimulate synaptic remodeling and neural circuit reconstruction; ideal for experiments focusing on learning, memory consolidation and senescent neuron function recovery.
Anti-Inflammatory Nervous System Research
Modulate central neuroimmune response; support research on chronic neuroinflammation, neurodegenerative inflammatory cascades and blood-brain barrier dysfunction.
Supplementary Compliance Disclaimer
This product is laboratory research reagent only. It is not approved for human clinical treatment, injection or oral consumption. All data described refers exclusively to preclinical laboratory research observations, not therapeutic medical claims.
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