Full Name: TB-500, Thymosin Beta-4 Fragment 17–23
Amino Acid Sequence: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln-OH (Abbreviation: Ac-LKKTETQ-OH, 7-amino acetylated linear heptapeptide)
Molecular Formula: C₃₉H₆₇N₉O₁₃
Molecular Weight: 877.99 g/mol
CAS Number: 885340-08-9
Appearance: Sterile lyophilized white powder, packaged in vials (main specifications: 5mg / 10mg / 20mg)
Purity: ≥98% as tested by HPLC, complete COA quality inspection report attached for each batch
R&D Background: TB-500 is the minimal active seven-amino fragment cleaved from full-length endogenous Thymosin Beta-4 (Tβ4, 43 amino acids). Tβ4 is widely expressed in nearly all mammalian cells except red blood cells and dominates cytoskeleton regulation and tissue regeneration. This short fragment retains all core repair activity of full-length Tβ4, with smaller molecular weight, stronger cell permeability, simpler chemical synthesis and better systemic distribution. It is extensively applied in wound healing, tendon/ligament regeneration, cardiovascular injury, anti-fibrosis and inflammation-related preclinical laboratory research.
2. Core Mechanism of Action
TB-500 does not bind traditional cell surface receptors; its core biological activity relies on intracellular G-actin monomer sequestration to remodel cytoskeleton, activating multiple repair signal cascades in damaged tissue:
- Actin cytoskeleton remodeling: Combine 1:1 with monomeric G-actin to reserve actin pool; upon injury signals, release G-actin to polymerize into F-actin, boost motility of fibroblasts, keratinocytes and endothelial cells to migrate toward lesion sites;
- Promote angiogenesis & microvascular reconstruction: Upregulate VEGF and eNOS expression, stimulate endothelial proliferation and new capillary formation, improve blood perfusion of avascular tissues such as tendons, ligaments and cartilage;
- Broad-spectrum anti-inflammatory regulation: Suppress NF-κB signaling pathway, reduce secretion of pro-inflammatory cytokines TNF-α, IL-1β, IL-6; shift tissue microenvironment from acute inflammatory phase to tissue remodeling phase to relieve swelling and tissue necrosis;
- Balanced collagen metabolism & anti-fibrosis: Moderately boost collagen synthesis for wound repair while inhibiting excessive collagen overdeposition, reduce scar hyperplasia and interstitial fibrosis in heart, liver and muscle tissue;
- Anti-apoptotic & cytoprotective effect: Activate ILK/Akt survival pathway, reduce oxidative stress and hypoxia-induced cell death of cardiomyocytes, muscle cells and corneal epithelial cells;
- Systemic long-lasting efficacy: Long plasma half-life up to 10–14 days after subcutaneous injection, can target remote damaged tissues via blood circulation with local injection-free systemic repair effects.
3. Core Research Efficacy (For Research Laboratory Use Only)
Soft Tissue & Skin Wound Healing Research
Accelerate epidermal cell migration, granulation tissue formation and vascular regeneration; core reagent for full-thickness skin wounds, burn injury, surgical incision and ulcer cell & animal model experiments. Significantly shorten healing cycle and lower scar formation rate.
Tendon, Ligament & Skeletal Muscle Regeneration
Improve blood supply of hypovascular connective tissue, repair strained tendinitis, ligament tear and exercise-induced muscle micro-trauma; key experimental material for sports injury rehabilitation and musculoskeletal regenerative medicine research.
Myocardial Ischemia & Cardioprotection
Reduce cardiomyocyte apoptosis after myocardial infarction, inhibit cardiac interstitial fibrosis, restore partial cardiac systolic function; applied to ischemia-reperfusion heart injury preclinical study.
Organ Anti-Fibrosis Research
Block TGF-β/Smad overactivation, alleviate liver fibrosis, myocardial scarring and pulmonary fibrosis lesions; auxiliary raw material for chronic inflammatory organ damage experiments.
Ocular Corneal Injury Repair
Promote corneal epithelial cell regeneration, relieve dry eye and corneal abrasion damage, widely used in ophthalmic epithelial repair cell testing.
Systemic Anti-Inflammation & Metabolic Tissue Repair
Regulate local immune response of chronic inflammatory lesions, reduce persistent tissue edema; compatible combined research with BPC-157 for synergistic multi-tissue regenerative effects.
Supplied as sterile lyophilized white powder, HPLC purity ≥98%, mainstream vial specifications: 5mg, 10mg, 20mg. Every batch is equipped with full COA, MSDS and HPLC chromatogram test documents.
As a high-efficiency short regenerative fragment of Thymosin Beta-4, TB-500 simplifies the molecular structure while completely retaining actin-binding and tissue repair biological activity. It drives cell migration, new blood vessel growth and inflammatory balance simultaneously, covering multi-organ repair from skin, muscle, tendon to heart and eye tissue, with stable long-term systemic bioactivity unmatched by many single-target repair peptides.
It serves as essential research material for in-vitro cell culture and animal model experiments covering wound healing, musculoskeletal regeneration, cardiovascular protection, organ fibrosis inhibition and ophthalmic epithelial repair.
Note: For laboratory research use only, not approved for human oral consumption or clinical injection treatment.
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