Vesugen (KED Tripeptide) – Full Detailed English Product Description
Product Overview
Vesugen, also known as the vascular tripeptide bioregulator, is a synthetic short peptide developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. Its core amino acid sequence is Lys-Glu-Asp (KED), extracted and synthesized based on regulatory peptide fragments isolated from animal aortic vascular tissue. Classified as a tissue-specific cytogen bioregulator, it selectively targets vascular endothelial cells and acts via epigenetic DNA modulation rather than simple receptor binding, making it a core laboratory reagent for cardiovascular aging, endothelial function and microcirculation research.
Basic Technical Specifications
- Peptide Name: Vesugen
- Sequence: H-Lys-Glu-Asp-OH (KED)
- Molecular Formula: C₁₅H₂₆N₄O₈
- Molecular Weight: 390.39 Da
- Purity: ≥99% (HPLC & LC-MS double verification, low single impurity)
- Appearance: White sterile lyophilized powder
- Solubility: Fully soluble in distilled water and 0.9% benzyl alcohol bacteriostatic water
- Standard Vial Sizes: 5mg / 10mg / 20mg sealed sterile vials
- Quality Documents: COA, HPLC chromatogram, mass spectrum identification report provided per batch
- Shelf Life: 24 months under proper sealed storage
- Storage Conditions: Long-term storage at -20°C, protected from light and moisture; strictly avoid repeated freeze-thaw cycles. Reconstituted solution can be stored at 2–8°C for up to 7 days
Mechanism of Action
- Epigenetic Regulation of Vascular Endothelial Genes
Vesugen penetrates endothelial cell membranes and enters the nucleus, directly binding to chromatin and promoter regions of vascular-related genes. It remodels condensed aging heterochromatin to reactivate suppressed genes responsible for endothelial integrity, vasodilation and cell proliferation, reversing age-related transcriptional decline in blood vessel tissue. - Normalize Endothelial Signaling Molecules
Downregulates overexpressed endothelin-1 (vasoconstrictor factor) and elevates synthase activity to balance vascular tension; restores connexin gap junction protein expression to improve intercellular communication between vascular wall cells. - Activate Sirtuin Anti-Aging Pathway
Significantly upregulates SIRT1 expression in endothelial cells, enhancing intracellular antioxidant capacity, clearing reactive oxygen species, and alleviating oxidative damage to vessel linings caused by aging, lipid deposition and inflammatory factors. - Anti-Inflammatory & Anti-Atherosclerotic Effects
Suppresses expression of pro-inflammatory adhesion molecules E-selectin and VCAM-1, reducing monocyte attachment to vessel walls; inhibits lipid foam cell formation, slowing the progression of atherosclerotic lesions in preclinical vascular models. - Improve Systemic Microcirculation
Regulates angiogenesis-related markers (Ki-67, GAP43) to support capillary regeneration; optimizes blood perfusion in cerebral, cardiac and peripheral microvascular networks, widely used for brain circulation and peripheral vascular disorder experiments.
Core Research Applications
- Vascular aging, endothelial senescence and cardiovascular anti-aging preclinical studies
- Atherosclerosis, hypertension and arterial wall lesion experimental models
- Cerebral microcirculation insufficiency, ischemic vascular injury and vascular encephalopathy research
- Endothelial cell culture, nitric oxide signal pathway and vascular tone regulation assays
- Sirtuin epigenetic anti-oxidation and vascular inflammation mechanism exploration
- Comparative study of Khavinson organ-specific bioregulators (Cartalax, Livagen, Testagen, Bronchogen)
- Peripheral artery disease and microcirculation dysfunction laboratory testing
Product Advantages
- Strict Vascular Tissue Specificity
Unlike similar KED-backbone peptides (Livagen KEDA), Vesugen shows exclusive tropism for aortic and capillary endothelial tissue with minimal off-target effects on liver, testicular or bronchial cells. - Ultra-High & Stable Batch Consistency
Multi-stage solid-phase synthesis and chromatographic purification guarantee ≥99% purity, low endotoxin content, meeting standards for cell culture and animal experiments. - Excellent Solubility & Lyophilized Stability
Vacuum freeze-drying prevents peptide degradation during cross-border transportation; dissolves completely without precipitation after reconstitution. - Complete Traceable QC Documentation
Every batch supplies full test records to support third-party laboratory verification and filing requirements.
Important Disclaimer
This product is for laboratory research use only. It is not approved for human , oral consumption, clinical therapy, food, cosmetic or veterinary applications. All biological activity data are limited to in vitro cell culture and animal preclinical models. Operate strictly following laboratory biosafety operating specifications.
Short Bullet Points for E-commerce Listing Page
- Vesugen (KED) vascular-specific tripeptide bioregulator, sequence Lys-Glu-Asp
- ≥99% HPLC & LC-MS verified purity, white sterile lyophilized powder
- Epigenetically modulates endothelial gene expression to protect blood vessel linings
- Balances nitric oxide & endothelin-1, boosts SIRT1 activity and reduces vascular inflammation
- Ideal reagent for atherosclerosis, microcirculation and cardiovascular aging research
- Multiple vial specifications available; full COA, HPLC and MS test reports included
- Long-term sealed storage at -20°C, 24-month shelf life
| Items | Specifications |
| Appearance | White sterile lyophilized powder |
| Shelf Life | 24 months under recommended storage |
| Storage Conditions | Long-term sealed storage at -20°C, avoid light, moisture and repeated freeze-thaw cycles; reconstituted solution stable at 2–8°C for maximum 7 days |
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Research & Reference Note
High quality Vesugen New Peptides Factory Supply High Quality with Good Price is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Disclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
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