Recombinant Human Erythropoietin (rhEPO) – Full Detailed Product Description
Product Overview
Erythropoietin (EPO) is a naturally occurring glycosylated hematopoietic hormone primarily secreted by renal interstitial fibroblasts under hypoxic conditions. Our lab-grade recombinant human EPO (rhEPO) is expressed and purified from mammalian CHO cell lines, fully matching the amino acid sequence and native glycosylation pattern of endogenous human EPO. It is a core research cytokine widely adopted for hematopoiesis, hypoxia signaling, stem cell differentiation, tissue protection and sports physiology laboratory studies.
Basic Technical Specifications
- Full Name: Recombinant Human Erythropoietin (rhEPO)
- CAS Number: 113427-24-0
- Amino Acid Length: 165 amino acid residues
- Molecular Weight: ~30.4 kDa (glycosylated protein, carbohydrate accounts for ~40% of total mass)
- Purity: ≥98% verified by SDS-PAGE, HPLC and LC-MS
- Biological Activity: Standardized in IU/mg, consistent bioactivity batch to batch
- Appearance: White sterile lyophilized powder
- Solubility: Dissolves rapidly in sterile water, PBS buffer and bacteriostatic water
- Standard Vial Specifications: 1000IU / 3000IU / 5000IU / 10000IU sealed sterile vials
- Quality Documents: COA, SDS-PAGE purity report, activity test sheet, mass spectrum identification provided per batch
- Shelf Life: 24 months under recommended storage
- Storage Conditions: Long-term sealed storage at -20°C, avoid light, moisture and repeated freeze-thaw cycles; reconstituted solution stable at 2–8°C for maximum 7 days
Mechanism of Action
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Core Erythropoiesis Regulation
rhEPO specifically binds to EPOR (EPO receptor) on bone marrow erythroid progenitor cells (BFU-E and CFU-E). It activates the JAK2/STAT5 signaling cascade to inhibit progenitor cell apoptosis, stimulate cell proliferation, accelerate hemoglobin synthesis, and drive terminal differentiation into reticulocytes and mature red blood cells, elevating whole-body blood oxygen transport capacity.
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Hypoxia-Inducible Factor (HIF) Pathway Modulation
EPO gene transcription is tightly controlled by HIF-1α under low oxygen environments. This product is critical for researching hypoxia feedback loops, renal oxygen sensing and anemia-related gene expression models.
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Multi-Tissue Cytoprotective Effects
Beyond hematopoietic function, EPO exerts anti-apoptotic, anti-inflammatory and antioxidant effects on neurons, cardiomyocytes, renal tubular cells and endothelial cells. It promotes angiogenesis and tissue repair, supporting regenerative medicine and organ injury preclinical research.
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Stem Cell Modulation
Synergizes with other growth factors to regulate mesenchymal stem cell differentiation, balance bone remodeling and modulate immune cell activity in co-culture experiments.
Core Research Applications
- Hematology research: Erythroid progenitor culture, anemia, hypoxia and red blood cell maturation experiments
- Hypoxia signaling & HIF pathway molecular mechanism studies
- Tissue protection research: Cardiac, renal, neural ischemic injury models
- Angiogenesis, endothelial cell proliferation and regenerative medicine testing
- Sports physiology, endurance and oxygen metabolism laboratory research
- Stem cell differentiation and bone metabolism related cell assays
- Drug screening for anti-anemia and organ-protective therapeutic candidates
Product Advantages
- Native Glycosylation & Stable Bioactivity
Expressed in CHO mammalian cells with complete human-style glycosylation; maintains full biological activity without denaturation after lyophilization. Batch-to-batch activity deviation strictly controlled below 8%. - High Purity & Low Endotoxin
Multi-step chromatographic purification removes host cell protein impurities and endotoxin, meeting strict standards for cell culture and animal injection experiments. - Convenient Reconstitution & Long-Term Stability
Vacuum freeze-dried formulation eliminates degradation during cross-border transportation; no insoluble precipitates after reconstitution. - Complete Traceable QC Files
Every batch supports full inspection documents for laboratory filing and third-party independent verification.
Important Disclaimer
This product is for laboratory research use only. It is prohibited for human clinical injection, blood disorder treatment, athletic performance enhancement, veterinary medication, food or cosmetic production. All biological data are limited to in vitro cell culture and animal preclinical models. Handle strictly in accordance with biological laboratory safety protocols.
Short Bullet Points for E-commerce Listing
- Recombinant Human Erythropoietin (rhEPO), native glycosylated cytokine from CHO cell expression
- ≥98% purity via SDS-PAGE & HPLC, standardized biological activity in IU
- Stimulates erythroid progenitor proliferation to boost red blood cell production
- Regulates HIF hypoxia pathway and delivers multi-organ cytoprotective effects
- Widely used for hematology, hypoxia, stem cell and tissue injury research
- Multiple IU specifications available; full COA, purity and activity test reports supplied
- Store sealed at -20°C away from light, 24-month shelf life
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