Name | Sermaglutide |
CAS number | 910463-68-2 |
Description | Semaglutide was originally designed as a powerful, long-lasting subcutaneous anti-diabetic drug. In 2019, oral semaglutide tablets were also approved for marketing, reducing the trauma of medication for diabetic patients and improving medication compliance and convenience. |
Molecular Formula | C187H291N45O59 |
Molecular Weight | 4113.57 g/mol |
Appearance | White powder |
Quality Standard | 99% |
Storage Condition | Store at -20°C. |
Shelf Life | >2 years if stored properly |
Sample package | Aluminium foil bag |
Commercial package | Aluminium Tin, Fiber drum |
Origin | China |
Semaglutide Blue Trihydrate More Info
Semaglutide is a GLP-1 receptor agonist developed by Novo Nordisk, engineered for extended half-life to enable once-weekly subcutaneous administration. It is approved for type 2 diabetes management and chronic weight management. The compound mimics endogenous GLP-1 to enhance glucose-dependent insulin secretion, suppress glucagon, and delay gastric emptying.
Production and Pharmaceutical Development
Semaglutide is synthesized via recombinant DNA technology, using yeast or mammalian cell systems, followed by chemical modification (e.g., fatty acid side chain) to prolong activity. Critical steps include peptide synthesis (SPPS or fermentation), purification, and formulation. Its design ensures stable pharmacokinetics, reducing dosing frequency compared to shorter-acting analogs.
Clinical Applications and Efficacy
Clinical trials demonstrate semaglutide’s ability to significantly reduce HbA1c (diabetes) and body weight . It also shows cardiovascular benefits, lowering MACE risk in high-risk patients. The weekly dosing regimen improves adherence versus daily GLP-1 therapies.
Safety and Regulatory Considerations
Semaglutide requires risk mitigation for potential adverse effects (e.g., gastrointestinal reactions, thyroid C-cell tumor risk in rodents). Patients with a history of medullary thyroid carcinoma or multiple endocrine neoplasia are contraindicated. Ongoing studies explore broader applications (e.g., NASH), while post-marketing surveillance monitors long-term safety.
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