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Azaperone

Azaperone structure

CAS No:
1649-18-9
Formula:
C19H22FN3O
Chemical Name:
Azaperone
Synonyms:
1-Butanone,1-(4-fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-;Butyrophenone,4′-fluoro-4-[4-(2-pyridyl)-1-piperazinyl]-;1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone;4′-Fluoro-4-[4-(2-pyridyl)-1-piperazinyl]butyrophenone;Azaperone;Fluoperidol;Stresnil;R-1929;Suicalm;NSC 170976
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Azaperone (R-1929) acts as a dopamine antagonist but also has some antihistaminic and anticholinergic properties. Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.

Azaperone is an N-arylpiperazine that is 2-(piperazin-1-yl)pyridine in which the amino hydrogen is replaced by a 3-(4-fluobenzoyl)propyl group. Used mainly as a tranquiliser for pigs and elephants. It has a role as an antipsychotic agent and a dopaminergic antagonist. It is a N-arylpiperazine, a N-alkylpiperazine, an aminopyridine, a tertiary amino compound, a member of monofluorobenzenes and an aromatic ketone.|Azaperone is a pyridinylpiperazine and butyrophenone agent that is capable of eliciting neuroleptic sedative and antiemetic effects. It is subsequently employed predominantly as a veterinary tranquilizer and mainly for pigs and elephants. At the same time, the agent generally does not see equine use as particular adverse reactions may happen. More rarely it may be used in humans as an antipsychotic drug, but this is uncommon.|A butyrophenone used in the treatment of PSYCHOSES.

Azaperone Basic Attributes

Molecular Weight：

327.4

Exact Mass：

327.40

EC Number：

216-715-8

UNII：

19BV78AK7W

NSC Number：

758969|170976

DSSTox ID：

DTXSID2045361

HScode：

2933990090

Characteristics

PSA：

36.4

XLogP3：

3.3

Appearance：

White or off-white crystalline

Density：

1.2±0.1 g/cm3

Melting Point：

73-75 °C

Boiling Point：

499.5°C at 760 mmHg

Flash Point：

255.9±28.7 °C

Refractive Index：

1.568

Storage Conditions：

0-6°C

Vapor Pressure：

4.14E-10mmHg at 25°C

Collision Cross Section：

180 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|180.3 Å² [M+H]+ [CCS Type: TW]|181.99 Å² [M+H]+

Safety Information

Packing level：

Ⅲ

Transport codes：

UN28116.1/PG3

hazard class code：

RTECS Number：

EU4550000

Marks：

Precautionary statement(s)：

Missing Phrase - N15.00950417

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 42 companies from 3 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)|Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)|Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

MeSH Entry Terms：

Azaperone

Azaperone Use and Manufacturing

Uses

Sedative; tranquilizer.

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients|Pharmaceuticals -> Animal Drugs -> Approved in Taiwan

Food Additive Classes：

Veterinary Drug -> TRANQUILLIZING_AGENT;

Computed Properties

Molecular Weight:327.4
XLogP3:3.3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:327.17469050
Monoisotopic Mass:327.17469050
Topological Polar Surface Area:36.4
Heavy Atom Count:24
Complexity:390
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Azaperone.

CAS No.: 1649-18-9

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Azaperone CAS 1649-18-9

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CAS No.: 1649-18-9

Grade: Pharmaceutical Grade

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