S-acetyl-L-glutathione is an acetylated modified reduced L-glutathione with better stability and cell membrane penetration compared to ordinary reduced L- glutathione. It resists decomposition by gastric acid and significantly enhances oral bioavailability. Widely used in skin whitening, anti-aging, liver protection, detoxification, and dietary supplementation, it is currently the highly favored upgraded form of glutathione in premium beauty and health care products.
Product Name: S-acetyl-L-glutathione
CAS No.: 3054-47-5
Molecular formula: C12H19N3O7S
Molecular weight: 349.36016
Purity: >98%
Package: 25KG per drum
Mechanism
S-acetyl-L-glutathione protects the molecular structure of glutathione by acetylating it, enabling resistance to gastric acid and digestive enzyme degradation, significantly enhancing oral absorption efficiency, and facilitating smooth penetration of cell membranes. Upon entering cells, it removes the acetyl group and rapidly converts into biologically active reduced glutathione. As a key antioxidant, it directly scavenges free radicals in the body, inhibits tyrosinase activity, reduces melanin synthesis and deposition, maintains cellular redox balance, and safeguards cell membrane integrity. This achieves core physiological functions such as antioxidant effects, skin whitening, pigmentation reduction, and cellular repair .
Test Items | Specification |
Appearance | White to off-white power |
Purity | ≥98% |
L-Glutathione | ≤1.0% |
Sulphates | ≤300ppm |
Chlorides | ≤200ppm |
Loss on drying | ≤0.5% |
Residual on ignition | ≤0.2% |
Total Heavy Metals | ≤10ppm |
Pb | ≤2 ppm |
Hg | ≤0.5 ppm |
Cd | ≤1 ppm |
As | ≤3 ppm |
Total Plate Count | ≤1000cfu/g |
E.Coli | Negative |
Salmonella | Negative |
Yeast and Mould | ≤100cfu/g |
Storage:Sealed packaging, stored at cool, dry and away from light & heat. |
JaYoo Biotech’s S-Acetyl Glutathione Powder COA confirms strict quality control for bulk supplement manufacturing, with product name S-Acetyl-L-Glutathione, CAS No. 3054-47-5, molecular formula C12H19N3O7S, molecular weight 349.36, and batch No. SGSH260421. The tested purity is 99.4%, exceeding the standard specification of ≥98%, while related L-Glutathione is only 0.33% against a limit of ≤1.0%. Key safety indicators meet specification, including total heavy metals ≤10 ppm, Pb ≤2 ppm, Hg ≤0.5 ppm, Cd ≤1 ppm, and As ≤3 ppm, with microbiological limits controlled at total plate count ≤1000 cfu/g, yeast and mold ≤100 cfu/g, and E. coli / Salmonella negative. The COA also confirms loss on drying 0.15%, residue on ignition 0.16%, sulphates ≤300 ppm, and chlorides ≤200 ppm. Residual solvent testing is not listed in this sample COA, but JaYoo Biotech can support additional third-party testing by common methods such as HPLC for assay/purity, ICP-MS or AAS for heavy metals, GC for residual solvents, and microbiological testing according to customer requirements. Packed in 25kg/drum, stored sealed in a cool, dry place away from light and heat, JaYoo Biotech’s S-Acetyl Glutathione Powder meets international quality expectations and supports supplement manufacturers and distributors with reliable documentation, safety control, and third-party quality verification.
JaYoo Biotech produces 99% pure S-Acetyl L-Glutathione Powder through a controlled manufacturing process designed for high purity, stable quality, and bulk supplement applications. The process starts with carefully selected raw materials, followed by an enzymatic reaction to prepare the glutathione intermediate under controlled temperature, pH, and reaction conditions. The material then enters the acetylation stage, where the acetyl group is introduced to improve the stability and bioavailability of the final S-Acetyl L-Glutathione ingredient.
After acetylation, the reaction solution is processed through membrane filtration to remove impurities, salts, and low-molecular residues. The filtered material is then further refined by purification, helping ensure high assay, low impurity levels, and consistent product quality. After purification, the material is carefully dried to produce a stable white to off-white crystalline powder with controlled moisture content.
Before release, every batch undergoes sample testing for key quality indicators, including appearance, purity, related substances, loss on drying, residue on ignition, heavy metals, and microbiological safety. JaYoo Biotech’s S-Acetyl L-Glutathione Powder can reach 99% purity, and the COA example shows a tested purity of 99.4%, with total heavy metals controlled at ≤10 ppm, Pb ≤2 ppm, Hg ≤0.5 ppm, Cd ≤1 ppm, As ≤3 ppm, and microbial limits meeting specification.
The qualified material is finally packed as finished S-Acetyl L-Glutathione Powder, typically in 25kg/drum packaging for bulk buyers. With strict in-process control, COA/MSDS documentation, and support for third-party quality testing, JaYoo Biotech ensures its S-Acetyl L-Glutathione Powder meets international quality standards for supplement manufacturers, nutraceutical brands, distributors, and OEM formulation customers.
S-Acetyl L-Glutathione Powder is a premium glutathione ingredient widely used in dietary supplements, beauty-from-within products, anti-aging formulas, and functional nutrition applications. With improved stability, strong antioxidant properties, and better formulation compatibility, it is an ideal raw material for supplement manufacturers, nutraceutical brands, cosmetic ingredient buyers, and OEM finished-product developers.
Dietary supplement:
S-Acetyl L-Glutathione is widely used in capsules, tablets, softgels, and powder formulas for daily antioxidant support. Its improved stability and bioavailability make it a premium glutathione option for high-end supplement brands.
Beauty and Skin Brightening Products
S-Acetyl L-Glutathione is popular in beauty-from-within supplements designed for skin radiance, even skin tone, and healthy complexion support. It is commonly used in oral beauty capsules, whitening formulas, and cosmetic nutrition products.
Anti-Aging and Cellular Health Formulas
As a stable antioxidant ingredient, S-Acetyl L-Glutathione helps support cellular protection against oxidative stress. It is suitable for anti-aging supplements, longevity formulas, and premium wellness products.
Liver Health and Detox Support
S-Acetyl L-Glutathione is used in liver support and detox formulas because glutathione plays an important role in the body’s natural detoxification system. It is often combined with ingredients such as NAC, milk thistle extract, alpha-lipoic acid, and vitamin C for advanced liver health supplements.
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