1. Product Overview
Kisspeptin-10 (also known as KP-10, Metastin 45-54) is a bioactive decapeptide composed of 10 amino acids, the shortest C-terminal fragment retaining core activity in the kisspeptin family. Manufactured via solid-phase synthesis and multi-stage purification, it appears as white to off-white loose lyophilized powder with excellent water solubility, stable physicochemical properties and consistent batch quality. It is a dedicated in vitro research reagent widely used in life sciences and biomedical research.
This product is intended for in vitro experiments in professional research institutions and laboratories only. It is not a drug or dietary supplement, contains no prohibited ingredients, and shall not be used for in vivo applications on humans or animals. 2. Key Advantages
- High Purity & Low Impurities: Purified by multiple chromatographic processes with purity ≥98%, minimizing experimental interference and ensuring reliable results.
- High Activity & Stability: Vacuum lyophilization preserves intrinsic bioactivity with minimal loss during storage and transportation.
- Easy Solubility: Compatible with common laboratory solvents for rapid, clear solution preparation.
- Consistent Quality: Standardized production with strict HPLC and MS testing per batch for stable performance.
- Compliant & Safe: For in vitro research only, free of stimulants and controlled substances, complying with reagent regulations.
3. Research Applications (In Vitro Only)
As a dedicated in vitro laboratory research tool, main applications include:
- Neuroendocrine Pathway Research: In vitro exploration of hypothalamic-pituitary-gonadal (HPG) axis signaling mechanisms to support basic endocrine research.
- Receptor Binding & Signaling Assays: Binding activity analysis of KISS1R (GPR54) receptor and downstream signal transduction mechanism studies.
- Cell Function Research: In vitro experiments on cell proliferation, migration, differentiation and angiogenesis to explore peptide regulation of cellular behaviors.
- Basic Metabolism & Reproduction Research: Cellular-level exploration of physiological metabolism and reproductive mechanisms to support basic medical research.
- Academic Research: Fundamental R&D in life sciences, biochemistry and cell biology for universities and research institutions.
4. Compliance Statement
- This product is an in vitro laboratory research reagent. It shall be operated only by qualified professional researchers in standard sterile laboratory conditions.
- Do not use for in vivo applications on humans or animals. Prohibited for diagnosis, treatment, physical conditioning, aesthetics and other non-research purposes.
- This product contains no stimulants or controlled prohibited substances, and is distributed only for academic and experimental use.
- Users shall strictly follow laboratory safety regulations. Users shall take full responsibility for all risks and liabilities caused by improper use.
| Items | Specifications |
| CAS No | 374675-21-5 |
| Product Name | Kisspeptin-10 / Metastin (45-54) |
| Appearance | White lyophilized powder |
| Specification | 10 pieces per box |
| Origin | Guangzhou |
| Purity | ≥98% HPLC |
| Storage | Sealed, cool, dry and dark environment |
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1. Pre-operation Preparation
This product is a laboratory-only research reagent. All operations must be performed by professional researchers in a standard sterile laboratory.
Clean the work bench in advance to keep it clean, dry and well ventilated, and remove sundries and residual reagents to avoid cross-contamination. Prepare sterile liquid handling devices, sealed containers, aqueous solvents and cleaning wipes. All utensils shall be cleaned, sterilized at high temperature and cooled down before use.
Operators shall wear lab coat, sterile gloves, protective goggles and dust-proof equipment properly to prevent direct contact of powder and solution with skin, eyes and respiratory tract. Inspect the vial before use to ensure good sealing, and confirm the material is free from moisture, caking and discoloration.
2. Reconstitution
Select suitable solvents such as laboratory-grade sterile water or phosphate buffered saline according to experimental protocols. Add solvent slowly along the inner wall of the vial with sterile tools. Do not impact the powder directly, as excessive bubbles may impair bioactivity.
Place the vial upright after solvent addition for full infiltration. Swirl the vial gently until the powder is completely dissolved and a clear, homogeneous solution is obtained. For high-precision cell experiments, filter the solution with a 0.22μm sterile filter.
3. Dilution and Experimental Application
To prepare working solutions of different concentrations, dilute the stock solution step by step with blank solvent. Mix gently after each dilution to ensure uniform concentration.
Draw required volume of solution with sterile tools and transfer it into culture dishes, test tubes and other experimental carriers. Conduct experiments in accordance with specified temperature, reaction duration, pH value and other parameters. Keep complete experimental records for full traceability.
4. Post-experiment Handling
Tighten and seal the vial immediately after use, then store it under specified conditions. Clean, sterilize and store all used laboratory utensils in accordance with standard laboratory rules.
Collect waste liquid, residual materials and used consumables separately. Dispose of them uniformly following laboratory hazardous waste management regulations. Random dumping is prohibited.
5. Additional Guidelines
- Prepare solutions right before use to maintain optimal bioactivity. Do not store diluted working solutions for a long time.
- Opened product has reduced stability. Use it as soon as possible and avoid repeated opening.
- Handle the product gently during operation and transportation to prevent package damage and material leakage.
- This product is only for in vitro scientific research. Do not alter its intended use, and it shall not be applied to non-research scenarios related to humans and animals.
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1. General Storage Requirements
This lyophilized peptide research material is sensitive to temperature, humidity and light. Store it in a cool, dry, dark and well-ventilated dedicated reagent area.
Keep away from heat sources, electrical equipment and direct sunlight. Maintain low humidity to prevent the powder from absorbing moisture and caking. Store separately from corrosive and volatile chemicals to avoid contamination.
2. Storage for Unopened Products
- Short-term storage: Keep well-sealed products in refrigerator at 2℃~8℃.
- Long-term storage: Tighten the cap thoroughly and store at -20℃.
Place products on the middle shelf and keep away from ground moisture. Do not stack heavy goods on top to avoid package damage. Follow the first-in, first-out rule. The shelf life is 24 months under standard storage conditions.
3. Storage for Opened Products
Fully tighten the cap immediately after sampling to minimize air exposure and reduce risks of oxidation and moisture absorption.
Store opened products at 2℃~8℃ away from light. Avoid frequent moving and repeated opening. Use the product as soon as possible to retain bioactivity.
4. Storage for Reconstituted Solution
Liquid solution is much less stable than lyophilized powder. Use it immediately after preparation.
For temporary storage, transfer the solution into a clean sealed container and keep it at 2℃~8℃ in dark place. Complete usage within 24 hours.
Do not store at room temperature or perform repeated freeze-thaw cycles, which will cause activity loss and deterioration. Dispose of turbid, precipitated or layered solution in accordance with laboratory hazardous waste regulations.
5. Management of Subpackaged Samples
Use airtight containers for divided samples. Place them together with desiccant in a light-proof box before refrigeration. Mark each container clearly with product name, subpackaging date and batch number for easy management.
6. Routine Inspection & Protection
Check the operation of refrigeration and freezing equipment regularly, as well as package and material status. Isolate damaged, damp or discolored products in a timely manner.
Turn on dehumidifiers in wet weather for better moisture protection. Handle products gently during transportation to prevent sealing failure caused by collision.
Hong Kong Bosen Peptide R&D Co., Limited
Hong Kong Bosen Peptide R&D Co., Limited is a professional biotechnology company headquartered in Hong Kong, with a focus on peptide research, development, production and global supply. Rooted in the Greater Bay Area’s strong biotech ecosystem, we integrate cutting-edge R&D capabilities, strict quality control systems and efficient global logistics to deliver high-quality peptide products and technical solutions to customers worldwide.
Core Business & Product Portfolio
We specialize in the R&D, customization and commercial production of high-purity peptides, modified peptides and related biotech raw materials. Our product portfolio covers:
- Therapeutic peptides: SS-31 (Elamipretide), Tirzepatide, Semaglutide, Retatrutide (RT20), etc.
- Functional peptides: GHK-Cu, TB500, KPV, NAD, Glutathione, etc.
- Custom peptide services: Custom synthesis of complex sequences, long-chain peptides (up to 200 amino acids) and cyclic peptides, as well as various modification services (N-methylation, unusual amino acid incorporation, etc.).
R&D & Manufacturing Strength
- Technical expertise: Mastery of core technologies including solid-phase peptide synthesis (SPPS), liquid-phase synthesis, advanced purification (HPLC) and strict structural characterization.
- Quality assurance: All products are produced in compliance with cGMP standards, with complete CoA, HPLC and MS reports to ensure batch-to-batch consistency and high purity (≥98%).
- Production capacity: Equipped with professional production bases in Guangzhou, supporting small-batch R&D samples to large-scale commercial production, with stable supply capacity.
Global Market & Service Philosophy
With a customer base spanning the Philippines, the United States, Brazil, Russia, Bangladesh and other regions, we adhere to the service philosophy of "Quality First, Customer Centric". We provide one-stop services including product consultation, customization, technical support and global logistics solutions (door-to-door delivery, customs clearance assistance), committed to becoming a reliable long-term partner for global biotech enterprises, research institutions and health industry clients.
Vision
We are dedicated to advancing peptide technology innovation, expanding the application of peptides in health and medical fields, and contributing to global human health with high-quality products and professional services.
ECHEMI Editorial Reference
Kisspeptin-10, also called Metastin (45-54), is a 10 amino acid peptide that corresponds to the bioactive C-terminal 45-54 amino acids of metastin, a metastasis suppressor gene product. It acts as a potent agonist of GPR54 (OT7T175, AXOR12), with approximately 8-fold higher binding affinity than metastin (Ki values of 0.042 and 0.34 nM, respectively, for displacement of metastin (40-54)). Metastin (45-54) induces calcium mobilization in GPR54-transfected cells (EC50 = 0.18-1.1 nM). It inhibits the migration of GPR54-transfected CHO cells at concentrations of 10-100 nM, equaling the potency of full length metastin.
Metastin is also known as kisspeptin 1 (KISS1). It is encoded by KISS1 gene, that is mapped to human chromosome 1q32. Metastin is a tumor suppressor protein, made up of 145 amino acids. The protein fragments contain RFamide motif at the C- terminal end. The encoded protein is expressed in the human hypothalamus, gonads, placenta, liver and pancreas. This novelpeptideis mainly isolated from the human placenta.
Kisspeptin-10 Synthetic is a single, non-glycosylated polypeptide chain containing 10 amino acids, having a molecular mass of 1302 Dalton and a Molecular formula of C63H83N17O14 .
Research & Reference Note
Research Grade Kisspeptin-10 Lyophilized Powder, Laboratory Biochemical Research Material is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Disclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Reviewed by ECHEMI Scientific Review - Platform editorial review for research chemicals
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