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Solubility Soluble in DMSO Storage Store at -20°C

General tips For obtaining a higher solubility, please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Stock solution can be stored below -20℃ for several months.

Shipping Condition Secure Appearance: Powder Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Retatrutide (LY3437943) acetate is a triple agonist peptide for the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R).

Retatrutide acetate inhibits human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643, and 0.775 nM, respectively. It exhibits activity on mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191, and 0.794 nM, respectively.

In vivo, Retatrutide (LY3437943) acetate engages with GCGR and enhances glucose tolerance in an ipGTT by acting through GIP or GLP-1 receptors. Activation via the glucagon receptor by Retatrutide acetate leads to significant weight reduction and increased energy expenditure. Retatrutide acetate can be utilized in research related to obesity.

The core benefit lies in its dual mechanism of "appetite suppression + increased energy expenditure," demonstrating potential surpassing existing single/dual-target drugs in weight loss, blood sugar reduction, and improvement of metabolic syndrome.

Main Benefits and Uses
Breakthrough Weight Loss Effect This is its most prominent advantage. Phase II clinical trials showed an average weight loss of 24.2% over 48 weeks; in the latest Phase III trial (TRIUMPH-4), the 12mg dose group achieved an average weight loss of up to 28.7% (approximately 32.3 kg) over 68 weeks, with some subjects losing more than 35%, an effect approaching that of metabolic surgery, significantly superior to current telpotrebide and smegglutide.

Type 2 Diabetes Management
In the Phase III trial for type 2 diabetes (TRANSCEND-T2D-1), after 40 weeks of treatment, glycated hemoglobin (HbA1c) decreased by an average of 1.7%-2.0%, accompanied by approximately 16.8% weight loss, suitable for obese or overweight diabetic patients.

Improved Fatty Liver (MASLD/MASH)

By activating glucagon receptors to promote liver fat breakdown, Phase II data showed that at the highest dose, over 90% of obese patients with fatty liver achieved normalization of liver fat content, making it a promising candidate drug for treating metabolic fatty liver.

Relief of Knee Osteoarthritis Pain

For obese individuals with knee osteoarthritis, while achieving significant weight loss, the drug significantly reduced WOMAC pain scores (with a maximum reduction of approximately 75.8%), and some patients even experienced complete relief of knee pain, resulting in significant improvement in physical function.

Comprehensive Improvement of Cardiovascular and Metabolic Indicators

In addition to weight loss, it effectively lowers systolic blood pressure (an average reduction of approximately 14.0 mmHg at the highest dose), triglycerides, non-HDL-C cholesterol, and inflammatory factors (hs-CRP), reducing cardiovascular risk from multiple dimensions.

Common side effects: Similar to other GLP-1 drugs, the main side effects are mild to moderate gastrointestinal reactions (nausea, diarrhea, vomiting, constipation), which mostly occur during the dose escalation period; in addition, some patients experience mild sensory abnormalities (numbness/tingling in the limbs).

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