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Product Information

1. • I. Basic Properties

     • Molecular Formula: C₄₀H₆₂N₁₂O₁₁

     • Molecular Weight: 887.01 Da

     • Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂

     • Appearance: White lyophilized powder

     • Purity: ≥98% (HPLC)

     • Solubility:

       • Water: Slightly soluble (<1 mg/mL, sonication recommended)

       • DMSO: Freely soluble (50 mg/mL)

     • Storage: -20°C protected from light; reconstituted solution stable ≤72h at 4°C

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     II. Research-Grade Mechanism

     Competitively binds SNARE complex components (SNAP-25 protein), inhibiting neurotransmitter vesicle-membrane fusion and reducing facial muscle contraction signals. In vitro studies confirm:

     • Decreased neuronal Ca²⁺ influx (IC₅₀=0.23 μM)

     • 62% suppression of acetylcholine release (10⁻⁶ M dose, PC12 cell model)

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     III. Research Applications

     1. Cellular Signaling Pathways

     Model	Protocol	Key Metrics
     Human neuronal cells	24h pre-treatment (10⁻⁷ M)	Ca²⁺ imaging (Fluo-4 AM)
     3D skin models	0.1% in Matrigel matrix	SNAP-25 expression (WB)

2. Formulation Development Reference

• Transdermal delivery: Lecithin/ (3:7) enhances permeation 4.2-fold

• Stability optimization: pH 5.0-6.5 buffer + 0.01% EDTA extends RT half-life to 18 days

IV. Specifications & Compliance

• Usage Notice

  • Intended Use: Cosmetic raw material or in vitro research reagent only.
    Prohibited: Injectable/oral use, clinical applications

  • Compliance Documents: COA, MSDS, GMP statement (non-pharmaceutical grade)

  • Safety Handling: Non-hazardous per GHS classification

• Applications

  Cosmetic Ingredient Development

  • Recommended Usage: 0.01%-0.1% (aqueous formulations)

  • Formulation Stability:

    • Compatible with common emulsion systems (O/W, W/O)

    • Maintains activity >30 days at pH 5.0-6.5

  In Vitro Mechanism Studies

  • Cellular signaling pathway analysis (requires independent ethics approval)

  • Transdermal absorption evaluation (Franz diffusion cell method)

Core Advantages

1. Precision Targeting – Specific SNARE complex modulation with defined mechanism

2. Comprehensive Data – Verified in vitro IC₅₀, transdermal parameters

3. Transparent Supply – Full traceability with release reports (Batch No. XXXXXX)

*Description based on peer-reviewed literature (DOI: 10.1111/jocd.12345) and internal QC standards. No efficacy claims implied. Applications must comply with Cosmetic Ingredient Safety Guidelines and local regulations.*

Company Introduction

csxj Technology Co., Ltd. is an innovative technology enterprise specializing in the field of weight management and metabolic health. We are dedicated to the R&D, production, and supply of high-quality solutions based on cutting-edge biotechnology for the global market, with core expertise in GLP-1-related products and high-purity active ingredients. Leveraging robust scientific capabilities and a stringent quality management system, we consistently deliver safe, efficient weight management and metabolic products and materials to meet diverse client needs. Driven by technological innovation and a customer-centric approach, we collaborate with partners to advance the health industry and empower global users in achieving healthier lifestyles.

Introduction to transportation
We usually use a safe shipping method and do not require you to go through any customs clearance. Free shipping to your address without worrying about any customs issues. We have a professional customs clearance team that 100% guarantees the safe delivery of your package. If anything happens to your package, we promise to send it again for free. Enjoy the second free reissue policy. We can safely ship large parcels of 1000-2000kg/time without any customs issues. Our mission is always to put safety first.

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