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Rutaecarpine

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Unit Price: Get Latest Price
CAS No.:

84-26-4

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

g/kg

Price valid (until):

2026-07-03

Company Type:
Manufactory
Location:
China
Qualification:
Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

  • Product Description

  • Seller Information

  • Inquiry History

  • Description
    Rutaecarpine (CAS Number: 84-26-4) is a natural indoloquinazoline alkaloid isolated primarily from the unripe fruit of the medicinal plant Evodia rutaecarpa (Wu Zhu Yu). It functions as a multi-target pharmacological research compound with prominent cardiovascular, anti-thrombotic, anti-inflammatory, and metabolic regulatory properties.
    Key Pharmacological Functions and Mechanisms
    • Vasodilation and Blood Pressure Regulation: Rutaecarpine is a potent TRPV1 receptor agonist. By activating TRPV1 channels on sensory nerve endings, it stimulates the release of Calcitonin Gene-Related Peptide (CGRP) and nitric oxide (NO). This cascade triggers strong endothelium-dependent relaxation of blood vessels, effectively lowering systemic blood pressure. It also blocks extracellular calcium (\(\text{Ca}^{2+}\)) influx in vascular smooth muscle cells to ease vascular tension.
    • Anti-Thrombotic and Anti-Platelet Activity: The compound functions as an effective platelet aggregation inhibitor. It prevents arterial thrombus (blood clot) formation by hindering phospholipase C (PLC) pathways and elevating intracellular cyclic AMP (cAMP) levels in blood platelets, reducing the risk of vascular occlusion without causing severe bleeding tendencies.
    • Cardioprotection Against Ischemia: In cardiovascular models, it safeguards heart tissues against myocardial ischemia-reperfusion injury. It stabilizes myocardial membranes, neutralizes free radicals, and curtails the leakage of cardiac damage markers like creatine kinase (CK) and lactate dehydrogenase (LDH).
    • Anti-Inflammatory and Analgesic Action: Rutaecarpine systematically alleviates inflammatory pain and edema. It acts by blocking the NF-\(\kappa\text{B}\) and MAPK signaling pathways, which down-regulates inducible enzymes (iNOS and COX-2) and dampens the production of pro-inflammatory cytokines such as TNF-\(\alpha \) and IL-6.
    • Induction of Drug Metabolism via AhR Activation: A highly distinct function of rutaecarpine is acting as a strong Aryl Hydrocarbon Receptor (AhR) agonist. It heavily upregulates hepatic drug-metabolizing enzymes, specifically Cytochrome P450 1A2 (CYP1A2). As a result, it drastically accelerates the clearance and metabolic breakdown of specific foreign substances—such as caffeine—in the liver.
    Botanical and Quality Control Functions
    • Official Chemical Marker: Alongside its structural relative evodiamine, rutaecarpine serves as the definitive HPLC analytical standard required by international pharmacopoeias to authenticate, evaluate, and control the quality and chemical safety of Evodia rutaecarpa extracts.

    Basic Info
    Product Name:

    Rutaecarpine

    Other Name:

    Indolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5(7H)-one,8,13-dihydro-;Rutecarpine;8,13-Dihydroindolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5(7H)-one;Rutaecarpine;Rhetine;NSC 258317;3,13,21-Triazapentacyclo[11.8.0.0[2,10].0[4,9].0[15,20]]henicosa-1(21),2(10),4(9),5,7,15(20),16,18-octaen-14-one

    CAS No.:

    84-26-4

    Molecular Formula:

    C18H13N3O

    InChIKeys:

    InChIKey=ACVGWSKVRYFWRP-UHFFFAOYSA-N

    Molecular Weight:

    287.32

    Exact Mass:

    287.32

    EC Number:

    1308068-626-2

    UNII:

    8XZV289PRY

    NSC Number:

    258317

    DSSTox ID:

    DTXSID00232884

    HScode:

    29339900

    Categories:

    Chinese Herbs

    Characteristics
    PSA:

    48.5

    XLogP3:

    3

    Appearance:

    white solid

    Density:

    1.5±0.1 g/cm3

    Melting Point:

    260 °C

    Boiling Point:

    550.1ºC at 760 mmHg

    Flash Point:

    286.5±32.9 °C

    Refractive Index:

    1.792

    Water Solubility:

    DMSO: 18 mg/mL clear yellow solution, soluble

    Storage Conditions:

    2-8°C

    Hazard Identification

    Classification of the substance or mixture

    Not classified.

    GHS label elements, including precautionary statements

    Pictogram(s) No symbol.
    Signal word

    No signal word

    Hazard statement(s)

    none

    Precautionary statement(s)
    Prevention

    none

    Response

    none

    Storage

    none

    Disposal

    none

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Manufactory

    Main Products:

    Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

    Location:

    Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

    Total Annual Revenue:

    $2.5 million-$5 million

    Total Employees:

    51-100

    Year of Establishment:

    2019

  • Inquiry History
    1 Inquiries
    Country Product Purchase Quantity Date Posted
    United States

    High Quality 98% CAS 84-26-4 Evodia Extract 98% Rutaecarpine Powder Bulk

    1 KG Dec 20, 2023
    Post an enquiry for this product
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