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Chlorogenic acid

Name: Chlorogenic acid
Brand: Cuicheng Bio
SKU: pr2606011595
Price: 300 USD
Availability: InStock

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CAS No.:

327-97-9

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

g/kg

Price valid (until):

2026-07-03

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
Seller Information
Inquiry History

Description

Chlorogenic acid (CAS Number: 327-97-9) is a natural caffeoylquinic acid derivative (phenolic acid) formed by the condensation of caffeic acid and quinic acid. It is found abundantly in green coffee beans, honeysuckle (Lonicera japonica), and various fruits.

It functions as a highly active, multi-target research tool, a premium cosmetic bioactive, and a functional ingredient in the pharmaceutical and food industries, celebrated for its antioxidant, anti-inflammatory, metabolic regulatory, and neuroprotective properties.

Key Pharmacological Functions and Mechanisms

Glucose and Lipid Metabolism Regulation (AMPK Activation): In metabolic syndrome and diabetes models, chlorogenic acid significantly activates the AMPK signaling pathway, which improves peripheral insulin sensitivity and enhances glucose uptake in skeletal muscles. It specifically inhibits hepatic Glucose-6-Phosphatase (G6Pase), reducing glycogenolysis and gluconeogenesis, which directly limits glucose output from the liver into the bloodstream to stabilize blood sugar. It also downregulates fatty acid synthase to reduce lipid accumulation in the liver.
Dual Antioxidant Action via Nrf2 Activation: Featuring a structure rich in phenolic hydroxyl groups, it serves as an exceptional free radical scavenger that directly traps reactive oxygen species (ROS) and prevents cellular lipid peroxidation. Concurrently, it acts as a strong Nrf2 pathway activator, upregulating endogenous protective enzymes such as superoxide dismutase (SOD), catalase (CAT), and heme oxygenase-1 (HO-1).
Targeted Anti-Inflammatory Action (NF-$\kappa\text{B}$ Inhibition): It limits systemic inflammation and tissue injury by blocking the NF-$\kappa\text{B}$ and MAPK cascades. This downregulates the inducible enzymes iNOS and COX-2, leading to a sharp decline in the release of pro-inflammatory cytokines like TNF-$\alpha $, IL-6, and IL-1$\beta $.
Neuroprotection and Cognitive Support: It crosses the blood-brain barrier to shield neurons from glutamate-induced excitotoxicity and amyloid-beta (A$\beta $) cellular injury. Furthermore, it acts as a natural acetylcholinesterase (AChE) inhibitor, increasing acetylcholine concentrations in the brain to rescue learning and memory deficits in neurodegenerative models.
Broad-Spectrum Antimicrobial and Antiviral Actions: Chlorogenic acid disrupts bacterial cells by increasing membrane permeability, causing intracellular leakage in pathogens like Staphylococcus aureus and E. coli. It also interferes with the replication cycles of specific respiratory viruses.

Cosmetic and Industrial Functions

UV Protection and Skin Brightening: In skincare formulations, it absorbs ultraviolet (UV) radiation and shields dermal fibroblasts from photoaging. It also moderately inhibits tyrosinase activity, suppressing excessive melanin synthesis to help brighten skin tone and fade hyperpigmentation.
Natural Food Antioxidant: It is widely utilized in the food industry to protect polyunsaturated fatty acids and fat-rich foods from oxidative rancidity, successfully extending product shelf life.
Quality Control Standard: Analytical laboratories rely on it as a definitive HPLC reference standard required by international pharmacopoeias to authenticate, evaluate, and standardize the quality of botanical extracts like honeysuckle or Eucommia ulmoides.

Certificates

Basic Info

Product Name:

Chlorogenic acid

Other Name:

Cyclohexanecarboxylic acid,3-[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1,4,5-trihydroxy-,(1S,3R,4R,5R)-;Chlorogenic acid;Cyclohexanecarboxylic acid,3-[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1,4,5-trihydroxy-,[1S-(1α,3β,4α,5α)]-;Cyclohexanecarboxylic acid,3-[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1,4,5-trihydroxy-,(1S,3R,4R,5R)-;(1S,3R,4R,5R)-3-[[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1,4,5-trihydroxycyclohexanecarboxylic acid;3-Caffeoylquinic acid;3-O-Caffeoylquinic acid;3-(3,4-Dihydroxycinnamoyl)quinic acid;Caffeoylquinic acid;3-O-(3,4-Dihydroxycinnamoyl)-D-quinic acid;NSC 407296;Heriguard;NSC 70861;SW 85834;5-Chlorogenic acid;108657-60-9;12626-41-4;15076-00-3;16310-14-8;16431-26-8;16431-25-7

CAS No.:

327-97-9

Molecular Formula:

C16H18O9

InChIKeys:

InChIKey=CWVRJTMFETXNAD-NCZKRNLISA-N

Molecular Weight:

354.30900

Exact Mass:

354.31

EC Number:

206-325-6

HScode:

29182900

Categories:

Skin Protecting

Characteristics

PSA:

164.75000

XLogP3:

-0.4

Appearance:

Solid

Density:

1.65g/cm3

Melting Point:

206-207 °C

Boiling Point:

665ºC at 760mmHg

Flash Point:

245.5ºC

Refractive Index:

-37 ° (C=1, H2O)

Water Solubility:

soluble in hot water;40 mg/mL at 25 °C

Storage Conditions:

0-6ºC

Toxicity:

LDLo intraperitoneal in rat: 4gm/kg

See More Chlorogenic acid Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Chlorogenic acid Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019

Inquiry History

6 Inquiries

Country	Product	Purchase Quantity	Date Posted
Malaysia	Chlorogenic Acid	25 G	Feb 22, 2024
Netherlands	Chlorogenic acid	100 KG	Apr 22, 2026
Argentina	chlorogenic acid	1 KG	Jan 7, 2026
Turkey	Green Coffee Bean	20 TON	Nov 1, 2024
India	Chlorogenic Acid	1.00 KG	Dec 11, 2023
Brazil	Chlorogenic Acid	5 G	Jan 31, 2024

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Chlorogenic acid

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

More Choices Find All Products for Sale 

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