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Reliable Quality DL-Pyroglutamic Acid CAS 149-87-1 for Cosmetic Moisturizers

Name: Reliable Quality DL-Pyroglutamic Acid CAS 149-87-1 for Cosmetic Moisturizers
Brand: ONERBIO
SKU: pr2606021218
Price: 10.16 USD
Availability: InStock

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Unit Price:

$10.16/KG FOB

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CAS No.:

149-87-1

Grade:

Cosmetics Grade

Content:

99%

Port:

Shanghai

Brand:

ONERBIO

Packaging:

25kg/drum

Price valid (until):

2026-12-31

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Wuhan Oner Biotech Co.,Ltd.

Company Type:

Distributor

Location:

China

Qualification:

Main Products:

Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

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Product Description
Seller Information

Description

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Product Name: DL-Pyroglutamic acid
CAS Number: 149-87-1
Molecular Formula: C₅H₇NO₃
Molecular Weight: 129.11 g/mol
Appearance: White to off-white crystalline powder

DL-Pyroglutamic acid, also known as 5-oxoproline or pidolic acid, is a cyclic lactam derivative of glutamic acid. It is a white to off-white crystalline powder, odorless or nearly odorless, and has a slightly acidic taste. It exists as a racemic mixture of D- and L-enantiomers. The compound is soluble in water, ethanol, and other polar solvents, but is practically insoluble in nonpolar organic solvents. It is stable under ordinary conditions, though it should be protected from moisture, heat, and strong oxidizing agents. It is typically stored in a tightly closed container in a cool, dry place. As a lactam of glutamic acid, it participates in glutathione metabolism and the gamma-glutamyl cycle. DL-Pyroglutamic acid is used as a biochemical reagent, a chiral building block, and an intermediate in pharmaceutical, agrochemical, and cosmetic applications. It may also serve as a humectant, moisturizer, and precursor for other pyrrolidine derivatives. Standard laboratory precautions are recommended, including adequate ventilation, eye protection, and gloves. Avoid inhalation, ingestion, and contact with skin and eyes. It is generally regarded as low toxicity.

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ITEMS	STANDARDS		RESULTS
Description	White to almost white powder		White powder
UV absorbance ratio	A250/A260 A280/A260	0.41-0.49 2.03-2.71	0.45 2.14
PH	2.0-4.0		2.68
Loss on drying	≤5.0%		2.64%
Assay (UV)	≥98.0%		99.17%
Transmittance	≥98.5%		99.1%
Heavy metals	≤10ppm		＜10ppm
Purity (HPLC)	≥98.0%		99.6%
Conclusion	It complies to the standard

For regulatory compliance (e.g., USP, EP, JP), raw material Vidarabine must meet several rigorous standards:

Assay (by HPLC): 98.0% – 102.0% on an anhydrous basis.
Related Substances: Limits for specific impurities, notably Ara-Hx (NMT 2.0%), as well as any unspecified individual impurity (NMT 0.1%) and total impurities (NMT 2.0%).
Residual Solvents: Must comply with ICH Q3C guidelines (Class 1 and 2 solvents limited or absent).
Heavy Metals: NMT 20 ppm (typically lower for injectable grades).
Water Content (Karl Fischer): NMT 6.0% (the material is hygroscopic to a degree).
Microbial Limits: Total aerobic microbial count (TAMC) ≤ 1000 CFU/g, absence of S. aureus, P. aeruginosa, and Candida albicans.

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As a high-purity pharmaceutical intermediate, L-Tyrosine Ethyl Ester Hydrochloride is predominantly utilized in the chemical synthesis of bioactive peptides, dopamine analogs, and melanin precursors. Its excellent solubility profile makes it an ideal chiral building block for asymmetric synthesis and a critical substrate in enzymatic reactions. Available in purity grades of ≥98% (HPLC), it meets stringent requirements for R&D and cGMP manufacturing processes. Reliable supply ensures batch-to-batch consistency for long-term project scalability.

Vidarabine is classified as a potential reproductive hazard and an irritant. Safety Data Sheets (SDS) mandate the following:

Hazard Statements (H360): May damage fertility or the unborn child (Category 1B).
Precautionary Measures: Use fume hoods and wear impermeable gloves (e.g., nitrile), lab coats, and safety goggles. Avoid generating airborne dust.
First Aid: In case of skin contact, wash immediately with copious soap and water. If inhaled, move to fresh air.
Storage: Store in tightly sealed, light-resistant containers at 2°C to 8°C (refrigerated) for long-term stability. Avoid freezing.

While superseded by newer nucleoside analogs (Acyclovir, Ganciclovir) for systemic use due to better bioavailability and lower toxicity, Vidarabine retains niche value. Its primary current application is ophthalmic ointment (3%) . Pharmacokinetically, the raw material has poor oral bioavailability (<10%) and is rapidly deaminated in the gastrointestinal tract, necessitating parenteral or topical administration.

Vidarabine API is a well-characterized, stable crystalline nucleoside analog. While its systemic use has declined, it remains a critical raw material for topical antiviral ophthalmic preparations, particularly where resistance to other agents occurs. Manufacturers must strictly control impurities (especially Ara-Hx) and water content to ensure final drug product efficacy.

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ECHEMI Editorial Reference

Solid
5-oxoproline is an oxoproline having the oxo group placed at the 5-position. It is an intermediate metabolite in the glutathione cycle. It has a role as a human metabolite. It is a pyrrolidinemonocarboxylic acid, a member of pyrrolidin-2-ones and an oxoproline. It is a conjugate acid of a 5-oxoprolinate.|A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.

Certificates

Basic Info

Product Name:

DL-Pyrrolidonecarboxylic acid

Other Name:

Proline,5-oxo-;Proline,5-oxo-,DL-;DL-Proline,5-oxo-;5-Oxoproline;DL-Pyrrolidonecarboxylic acid;DL-Pyroglutamate;5-Oxo-DL-proline;(±)-Pyroglutamic acid;DL-Pyroglutamic acid;DL-2-Pyrrolidinone-5-carboxylic acid;DL-2-Pyrrolidone-5-carboxylic acid;(±)-2-Pyrrolidone-5-carboxylic acid;5-Oxopyrrolidine-2-carboxylic acid;NSC 40887

CAS No.:

149-87-1

Molecular Formula:

C5H7NO3

InChIKeys:

InChIKey=ODHCTXKNWHHXJC-UHFFFAOYSA-N

Molecular Weight:

129.11400

Exact Mass:

129.11

EC Number:

205-748-3

NSC Number:

143034|40887

HScode:

29337900

Categories:

Skin Humectant

Characteristics

PSA:

66.40000

XLogP3:

-0.8

Appearance:

white powder

Density:

1.38 g/cm3

Melting Point:

181-183 °C

Boiling Point:

453.1ºC at 760 mmHg

Flash Point:

227.8ºC

Refractive Index:

1.511

Water Solubility:

H2O: 5.67 g/100 mL (20 ºC)

Storage Conditions:

Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep contai

Vapor Pressure:

1.79E-09mmHg at 25°C

See More DL-Pyrrolidonecarboxylic acid Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More DL-Pyrrolidonecarboxylic acid Safety Data Sheet 

Seller Information

Business Type:
Distributor

Main Products:
Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

Location:
Changqing 5th Road, Jianghan District

Payment Terms:
TT against copy of documents

Average lead Time:
5

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
5-10

Year of Establishment:
2020

Wuhan Oner Biotech Co.,Ltd. located in the popular city of Wuhan, specilize in producing and developing pharmaceutical & its intermediates, Cosmetics Raw Material and Intermediate, food additive, Plant extracts,and in distributing the products of our own company. We serves our clients by supplying high-quality.These products are manufactured in ISO 9001 certified plants and have continuously been passing quality inspection by CIQ (China Entry & Exit Inspection and Quarantine Bureau),100% pass rate. Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , the products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc. With constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.
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Reliable Quality DL-Pyroglutamic Acid CAS 149-87-1 for Cosmetic Moisturizers

Product Description

Seller Information