High-Purity Natural Nucleoside Derivative 5-Methyluridine for Oligonucleotide Synthesis

Applications:

• RNA modification and methylation research

• Epitranscriptomic studies (e.g., detection of m⁵U modifications)

• Synthesis of modified oligonucleotides and antisense agents

• Substrate for enzymatic assays (e.g., methyltransferases)

• Internal standard in mass spectrometry-based nucleoside analysis

With its high purity and well-characterized physicochemical properties, 5-Methyluridine is an essential reference standard and building block for advanced nucleic acid chemistry and molecular biology research.

Vidarabine is classified as a potential reproductive hazard and an irritant. Safety Data Sheets (SDS) mandate the following:

• Hazard Statements (H360): May damage fertility or the unborn child (Category 1B).

• Precautionary Measures: Use fume hoods and wear impermeable gloves (e.g., nitrile), lab coats, and safety goggles. Avoid generating airborne dust.

• First Aid: In case of skin contact, wash immediately with copious soap and water. If inhaled, move to fresh air.

• Storage: Store in tightly sealed, light-resistant containers at 2°C to 8°C (refrigerated) for long-term stability. Avoid freezing.

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While superseded by newer nucleoside analogs (Acyclovir, Ganciclovir) for systemic use due to better bioavailability and lower toxicity, Vidarabine retains niche value. Its primary current application is ophthalmic ointment (3%) . Pharmacokinetically, the raw material has poor oral bioavailability (<10%) and is rapidly deaminated in the gastrointestinal tract, necessitating parenteral or topical administration.

Vidarabine API is a well-characterized, stable crystalline nucleoside analog. While its systemic use has declined, it remains a critical raw material for topical antiviral ophthalmic preparations, particularly where resistance to other agents occurs. Manufacturers must strictly control impurities (especially Ara-Hx) and water content to ensure final drug product efficacy.