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P21|Premium in stock

21 Inquiries

Unit Price:

$96/UNIT FOB

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CAS No.:

128-37-0

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Brand:

Pharma;Conutrix

Packaging:

10 vials/box

Price valid (until):

2026-07-04

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Anhui Ruibang Trading Co., Ltd

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Retatrutide,Tirzepatide,Semaglutide,Cynomorium Songaricum Extract,Bull Penis Powder,Deer Penis Extract

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Product Description
Seller Information
Inquiry History

Description

P21 (P021) is a premium-grade synthetic peptide derived from the active region of ciliary neurotrophic factor (CNTF), engineered for exceptional blood-brain barrier permeability and metabolic stability. As a potent neurotrophic research tool, it acts as a selective inhibitor of leukemia inhibitory factor (LIF) signaling, driving robust upregulation of brain-derived neurotrophic factor (BDNF) to promote neurogenesis, synaptic plasticity, and cognitive resilience. Our premium P21 formulation offers unmatched purity, stability, and batch consistency, making it the gold standard for cutting-edge research in neurodegeneration, cognitive enhancement, and neuroprotection. Currently in stock and ready for immediate global shipment.

1.1 Core Product Details

Product Name: P21 (P021) Acetate | Premium Grade
CAS Number: Not commercially assigned (research compound)
Molecular Formula: C₂₁H₃₅N₇O₉
Molecular Weight: 529.55 Da
Amino Acid Sequence: Ac-Asp-Gly-Gly-Leu-Ala-Gly-NH₂ (Ac-DGGLAG-NH₂)
Structural Modifications: N-terminal acetylation + C-terminal adamantylation (enhances BBB penetration & stability)
Form: Lyophilized white to off-white powder
Purity: ≥99.0% (HPLC & Mass Spectrometry verified, third-party tested)
Availability: Premium in stock, ready for immediate shipment
Intended Use: For laboratory research purposes only (not for human or veterinary use)

1.2 Premium Grade Differentiators

Our premium P21 stands apart from standard research-grade peptides through:

Ultra-High Purity: ≥99.0% purity (vs. 95-98% for standard grades), eliminating trace contaminants that skew experimental results
cGMP & ISO Compliance: Manufactured in FDA-registered, cGMP-compliant facilities under ISO 9001:2015 quality management systems
Advanced Purification: Multiple rounds of preparative HPLC purification and rigorous quality control
Stability Optimization: Specialized lyophilization process preserving peptide integrity for extended shelf life
Complete Documentation: Full COA (Certificate of Analysis), HPLC chromatogram, and MS report provided with every batch
Batch Consistency: Strict process controls ensure identical performance across all production batches

2. Scientific Background & Development

2.1 Discovery & Origins

P21 (P021) was developed by Dr. Khalid Iqbal's research group at the New York State Institute for Basic Research in Developmental Disabilities, first published in Neurobiology of Aging (2013) and Journal of Alzheimer's Disease. It was rationally designed to address the limitations of native CNTF—a large protein (~23 kDa) that cannot cross the blood-brain barrier, has poor plasma stability, and causes adverse effects in clinical trials. P21 was engineered as a minimal active fragment (residues 148-151 of CNTF) with chemical modifications to enhance bioavailability and CNS penetration.

2.2 Structural Advantage

The defining feature of premium P21 is its optimized molecular structure:

Small Size: Tetrapeptide structure enables efficient blood-brain barrier crossing
Chemical Modifications: N-terminal acetylation prevents enzymatic degradation; C-terminal adamantylation increases lipophilicity and CNS uptake
Targeted Activity: Retains only the neurotrophic active region of CNTF, avoiding off-target effects associated with full-length protein
Metabolic Stability: Enhanced resistance to proteolytic cleavage, extending biological half-life

2.3 Receptor & Signaling Profile

P21 exhibits high specificity for LIF receptor (LIFR) with minimal affinity for other cytokine receptors:

Primary Target: Competitive antagonist of LIF/LIFR signaling pathway
Secondary Effect: Indirect activation of BDNF/TrkB signaling cascade
Tissue Distribution: Highest activity in hippocampus, cortex, and olfactory bulb—key regions for learning and memory

3. Mechanism of Action

3.1 Primary Signaling Pathway

P21 exerts its neurotrophic effects through a well-characterized dual mechanism:

LIF Inhibition: Binds competitively to LIF receptors without activating downstream JAK/STAT signaling, releasing tonic inhibition on BDNF transcription
BDNF Upregulation: Elevated BDNF levels activate TrkB receptors, initiating a cascade of neuroprotective and neurogenic responses
Downstream Effects: Promotes neuronal survival, dendritic arborization, synaptic strengthening, and adult hippocampal neurogenesis

3.2 Neuroprotective & Cognitive Pathways

Beyond neurogenesis, P21 modulates multiple pathways critical for brain health:

Tau Pathology Reduction: Inhibits tau hyperphosphorylation, reducing neurofibrillary tangle formation
Amyloid Beta Regulation: Modulates APP processing, reducing Aβ plaque accumulation
Anti-Inflammatory Action: Inhibits NF-κB pathway, reducing microglial activation and pro-inflammatory cytokine release
Antioxidant Defense: Enhances SOD and catalase activity, mitigating oxidative stress damage
Mitochondrial Protection: Stabilizes mitochondrial membrane potential, reducing apoptotic signaling

3.3 Cellular & Molecular Effects

Premium P21 treatment leads to measurable improvements in:

Neuronal Proliferation: 2-3x increase in hippocampal neural progenitor cell proliferation
Synaptic Plasticity: Enhanced long-term potentiation (LTP) and synaptic connectivity
Cognitive Function: Improved spatial memory, learning capacity, and executive function in preclinical models
Neuronal Survival: Reduced neuronal loss in models of ischemia, trauma, and neurodegeneration

Items	Specifications
p21	10mg*10vials

Basic Info

Product Name:

2,6-Di-tert-butyl-4-methylphenol

Other Name:

Phenol,2,6-bis(1,1-dimethylethyl)-4-methyl-;p-Cresol,2,6-di-tert-butyl-;2,6-Bis(1,1-dimethylethyl)-4-methylphenol;CAO 1;CAO 3;Dalpac;DBPC;Deenax;2,6-Di-tert-butyl-p-methylphenol;4-Hydroxy-3,5-di-tert-butyltoluene;Impruvol;Ionol;Ionole;4-Methyl-2,6-di-tert-butylphenol;Parabar 441;Sustane BHT;Tenamene 3;Topanol OC;Vianol;BHT;Butylated hydroxytoluene;Topanol O;Topanol;Dibunol;Nonox TBC;AO 4K;Dibutylated hydroxytoluene;Ionol 1;Buks;2,6-Di-tert-butylcresol;Stavox;Di-tert-Butyl-4-methylphenol;o-Di-tert-butyl-p-methylphenol;Di-tert-butyl-p-cresol;Antioxidant KB;2,6-Di-tert-butyl-p-cresol;Antioxidant 4K;Sumilizer BHT;Di-tert-butylcresol;Catalin CAO 3;Chemanox 11;Vanlube PCX;Vanlube PC;Advastab 401;2,6-Di-tert-butyl-p-cresole;Antioxidant 29;AO 29;Antioxidant 30;P 21;Antioxidant DBPC;Agidol;Alkofen BP;Kerabit;Agidol 1;AO 4;Vulkanox KB;2,6-Di-tert-butylmethylphenol;Nocrac 200;2,6-Di-tert-butyl-4-hydroxytoluene;2,6-Di-tert-butyl-4-methyl-1-hydroxybenzene;Ionol BHT;AOX 4;AOX 4K;Antioxidant 4;Tenox BHT;Topanol BHT;Swanox BHT;2,6-Di-tert-butyl-4-methylhydroxybenzene;Antioxidant 264;Vanox PC;Antage BHT;3,5-Di-tert-butyl-4-hydroxytoluene;Popol;Ralox BHT;Permanax BHT;Antioxidant MPJ;Topanol OL;Naugard BHT;2,6-Di-tert-butyl-p-cresol;BAT;Ultranox 226;Lubrizol 817;2,6-Di-tert-butyl-4-methylphenol;P 21 (phenol);T 501;Ionol 330;Yoshinox BHT;2,6-Bis(tert-butyl)-4-methylphenol;36631-28-4;42615-30-5;50356-19-9;50641-99-1;52683-46-2;53571-70-3;58500-82-6;83047-16-9;97123-41-6;102962-45-8;259752-53-9;290348-23-1;338986-13-3;1394965-02-6;1456709-94-6;1847425-90-4;2055662-96-7

CAS No.:

128-37-0

UN No.:

3077

Molecular Formula:

C15H24O

InChIKeys:

InChIKey=NLZUEZXRPGMBCV-UHFFFAOYSA-N

Molecular Weight:

220.35000

Exact Mass:

220.35

EC Number:

246-911-9

HScode:

2907199090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

20.23000

XLogP3:

5.3

Appearance:

White crystals or crystalline powder

Density:

1.048 g/cm³ @ Temp: 20 °C

Melting Point:

70 °C

Boiling Point:

265 °C

Flash Point:

127ºC

Refractive Index:

1.4859

Water Solubility:

H2O: insoluble

Storage Conditions:

0-6ºC

Vapor Pressure:

<0.01 mm Hg ( 20 °C)

Vapor Density:

7.6 (vs air)

Flammability characteristics:

Class IIIB Combustible Liquid: Fl.P. at or above 200°F.

See More 2,6-Di-tert-butyl-4-methylphenol Properties 

Hazard Identification

Classification of the substance or mixture

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H410 Very toxic to aquatic life with long lasting effects
Prevention	P273 Avoid release to the environment.
Response	P391 Collect spillage.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from strong oxidants and strong bases. Well closed.Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids.

See More 2,6-Di-tert-butyl-4-methylphenol Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Retatrutide,Tirzepatide,Semaglutide,Cynomorium Songaricum Extract,Bull Penis Powder,Deer Penis Extract

Location:
Hefei, Provincia de Anhui

Year of Establishment:
2026

Inquiry History

21 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	butylated hydroxy toluene	1500 KG	May 12, 2026
United States	P21	10 PCS	Mar 20, 2026
Poland	BHT (Butylated Hydroxytoluene)	1000.00 KG	Jan 21, 2026
India	4 Butylated tolune(BHT)	10.00 KG	Dec 19, 2025
Pakistan	bht	20 KG	May 19, 2025
Germany	Butylated Hydroxytoluene	10 KG	Nov 21, 2024
United States	Butylated hydroxytoluene	5 MT	Jun 26, 2024
South Korea	BUTYLATED HYDROXYTOLUENE	1 20' Fcl	Jun 5, 2024
Pakistan	Butylated hydroxytoluene Food Grade best selling	12 MT	Nov 8, 2023
United States	Top Quality p21 Butylated Hydroxytoluene 99% white powder junjia	1 MT	Oct 20, 2023
India	Butyl hydroxy Toluene	500.00 KG	Feb 12, 2026
Pakistan	Butylated Hydroxytoluene	5 KG	Jan 5, 2026
India	Butylated hydroxytoluene	20 MT	Jan 4, 2025
Egypt	Butylated hydroxytoluene(BHT)	1.00 TON	Dec 25, 2024
Pakistan	Butylated Hydroxytoluene	5000 KG	Feb 5, 2024
India	2,6 Di Tert Butyl P-Cresol	1 KG	Sep 30, 2023
Yemen	Butylated hydroxytoluene	1.00 KG	Jun 29, 2023
Mexico	Butylated Hydroxytoluene	1000 KG	Sep 29, 2024
Morocco	Inhibiteur Butylated hydroxytoluene (BHT)	500 KG	Sep 11, 2023
United States	Butylated Hydroxytoluene CAS NO. 128-37-0 99% powder	5 MT	Jun 26, 2024

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