Survodutide | Premium in Stock (English Brief Intro)

Basic Information

• Alias: BI 456906
• CAS No.: 2805997-46-8
• Sequence: 29-amino acid acylated peptide (C18 fatty acid modified)
• Molecular Formula: C₁₉₂H₂₈₉N₄₇O₆₁
• Molecular Weight: ~4,232 Da
• Appearance: White/off-white sterile lyophilized powder
• Solubility: Freely soluble in water, PBS, and normal saline
• Storage: -20°C, protected from light & moisture; shelf life: 24 months

Core Mechanism & Applications (For Research Use Only)

• Mechanism: Potent dual agonist of GLP-1 receptor (GLP-1R) and glucagon receptor (GCGR); EC₅₀ = 0.33 nM (GLP-1R) / 0.52 nM (GCGR) in CHO-K1 cells.
• Key Research Uses:
  1. Metabolic & Obesity Research: Reduces food intake, increases energy expenditure, lowers body weight, and improves lipid profiles in preclinical models.
  2. Glycemic Control: Enhances glucose-dependent insulin secretion and improves insulin sensitivity.
  3. Liver & MASH Research: Reduces hepatic triglycerides, improves steatosis, and shows potential for metabolic dysfunction-associated steatohepatitis (MASH)
  4. Pharmacology & Drug Development: Long-acting (half-life ~6 days) for once-weekly dosing studies.