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Brief Introduction of Retatrutide:
Retatrutide is a new type of multi-target peptide drug developed by Eli Lilly and Company of the United States, it is a triple receptor agonist of GLP-1R/GIPR/GCGR. Its core mechanism is to regulate the metabolic process by activating glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon (GCG) receptors at the same time, and is used for the treatment of obesity and type 2 diabetes. The following are its key features:
Mechanism of Action and Molecular Structure of Retatrutide:
1)Triple Agonist Design
- GLP-1 receptor: Retatrutide delays gastric emptying, suppress appetite, and promote insulin secretion.
- GIP receptor: Retatrutide enhances insulin sensitivity and regulate central satiety signals.
- Glucagon receptor (GCGR): Retatrutide activates liver energy metabolism, promote lipolysis and glycogenolysis, and increase basal metabolic rate.
The triple synergistic effect increases energy consumption while reducing energy intake, significantly improving weight loss effects.
2) Structural Optimization
- Based on the GIP skeleton modification, non-natural amino acids (such as α-methylleucine at position 13) are introduced to enhance receptor affinity.
- The half-life is extended to 7 days through fatty acid side chain modification, supporting subcutaneous once a week.
Test Items
| Specifications |
Appearance
| White or almost white powder |
Solubility
| Freely soluble in water |
| Water Content (K.F) | Not more than 8.0% |
| Sodium Salt | Not more than 5.0% |
| Peptide Purity (HPLC) | Not less than 99.0% |
Related Substances (HPLC) | Total impurities | Not more than 2.0% |
| Maximum single impurity | Not more than 1.0% |
| Peptide Content | Not less than 85.0% |
Organic Residual Solvents
| Acetonitrile | Not more than 0.041% |
| Dichloromethane | Not more than 0.060% |
| N, N-Dimethylformamide | Not more than 0.088% |
| Bacterial Endotoxins | Less than 10 EU/mg |
Microbial Limits | Total Aerobic Microbial Count | Not more than 100 CFU/g |
| Total combined Yeasts & Mould Count | Not more than 100 CFU/g |
Clinical Effects and Core Data of Retatrutide:
1) Outstanding Weight Loss Effect:
- 48 weeks of treatment: The average weight loss in the 12mg dose group reached 24.2%, significantly better than existing drugs (such as Semaglutide and Tirzepatide).
- Gender differences: Women have a more significant weight loss effect (28.5% vs. men 21.2%).
- Dose dependence: From the starting dose of 2mg to 12mg, the weight loss ratio increases with the dose.
Comparison of Weight Loss Effects at Different Doses (48-Week Data):
| Doses | 4mg | 8mg | 12mg |
| Weight Loss Ratio | ~8.7% | ~17.5% | ~24.2% |
| Waist Circumference Reduction | -2.1cm | -6.1cm | -10.2cm |
2) Comprehensive Improvement of Metabolism:
- Blood sugar control: Significantly reduce glycated hemoglobin (HbA1c), and doses above 4mg are better than dulaglutide.
- Cardiovascular metabolism: Improve triglyceride, cholesterol and blood pressure levels, potentially reducing cardiovascular risks.
- Expanded indications: Used in research for metabolic-related diseases such as polycystic ovary syndrome (PCOS).
Indications and Efficacy:
★ Obesity Treatment:
In the Phase II clinical trial, patients in the highest dose group (12 mg) lost an average of 24.2% weight after 48 weeks, and some patients lost more than 30%.
★ Metabolic Dysfunction-Associated Fatty Liver Disease (MASLD):
Retatrutide can reduce liver fat content by 86%, and more than 85% of patients achieve regression of liver steatosis.
★ Type 2 Diabetes:
Significantly reduce glycated hemoglobin (HbA1c) and improve blood sugar control.
★ Potential Cardiovascular Benefits:
Animal studies have shown that it may indirectly protect cardiovascular health by improving blood pressure and heart function, but further clinical verification is needed.
Market Prospects and Challenges:
◎ Differentiation Advantages:
Compared with existing GLP-1 single-target (such as Semaglutide) or dual-target drugs (such as Tirzepatide), the triple mechanism of Retatrutide has greater potential in weight loss and metabolic improvement.
◎ Cost and Accessibility:
Currently, the production cost of peptide drugs is relatively high, but the long-acting properties of Retatrutide may reduce the frequency of medication and improve patient compliance.
Under ideal, controlled conditions, Adipotide once showed promising advantages:
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Highly Targeted and Direct: Unlike general weight-loss drugs that work systemically by suppressing appetite or boosting metabolism, it directly "destroys" the fat tissue itself, theoretically making it more efficient.
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Potentially Fast-Acting: In monkey studies, significant body fat reduction was observed within weeks.
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We offer various types of peptides, about peptides, we can offer good quality, good price. Customers who have ordered our products (peptides) have received very good feedback. Reliable buyers around the world can contact us about peptides
1. Ultra-low temperature freezing: Freeze the highly active ingredients at -196 degrees to put the active ingredients into a dormant state.
2. Effective regeneration: Add the solvent to the powder when using it, and it can be effectively regenerated after mixing, ensuring the high activity and high stability of the product. We offer various types of peptides, and we can provide excellent quality and preferential prices for peptides. The feedback from customers who have ordered our products (peptides) is very good. Reliable buyers around the world can contact us for peptide matters. We offers an unparalleled combination of quality, performance and value. If you have any questions about this product or want to learn more about how it can benefit your business, please feel free to contact us. We are committed to providing excellent customer service and helping our customers achieve their business goals.We look forward to the opportunity to work with you and help you succeed.
Our main products include peptide products and pharmaceutical raw materials. We boast strong R&D capabilities, superb synthesis technology, and advanced quality control methods. We actively promote joint ventures and cooperation with major enterprises and manufacturers, serving society and users with the concept of industrial development. We always adhere to market demand orientation and continuously develop new high-tech chemical products and pharmaceutical intermediates.
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Samaglutide Product Introduction
I. Basic Information
Name: Samaglutide
CAS No.: 910463-68-2
Molecular Formula: C₁₈₇H₂₉₁N₄₅O₅₉
Molecular Weight: 4113.58 Da
Structure: Long-acting GLP-1 receptor agonist, fatty acid modified, half-life approximately 7 days
Appearance: White lyophilized powder
Purity: ≥99% (HPLC-MS)
II. Mechanism of Action (GLP-1 monoreceptor agonist)
Glucose Control: Glucose-dependent insulinotropic effect, glucagon inhibition
Weight Loss: Delays gastric emptying, potent appetite suppression, reduces calorie intake
Cardiovascular Protection: Reduces the risk of major adverse cardiovascular events
III. Core Efficacy
Weight Loss
STEP 1: Average weight loss over 68 weeks 14–15% (approximately 15.5 kg)
Over 80% fat loss, muscle preservation
Blood sugar reduction
Type 2 diabetes: HbA1c reduction of 1.5–2.0%
Improved metabolism
Benefits include lowering blood pressure, improving blood lipids, and reducing fatty liver
Cardiovascular benefits
SELECT trial: 20% reduction in MACE risk in overweight/obese individuals
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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