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Purity 99% - Customization available Melanotan I 10mg*10vials

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CAS No.:

75921-69-6

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Chinese mainland

Brand:

any

Packaging:

10mg*10vials

Price valid (until):

2026-09-20

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Guangzhou Anymang Technology Co., Ltd.

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

45 days

Qualification:

Main Products:

Semag lutide,Tirzepatide,Retatrutide,raw material,GHK-CU,TB500(Thymosin B4 AceTate)

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Product Description
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Inquiry History

Description

Product Detail

13-mer linear peptide, sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Fep-Arg-Trp-Gly-Lys-Pro-Val-NH₂
Molecular formula: C
78
Please provide the text that needs to be translated accurately and fluently into H
111
Please provide the text that needs to be translated accurately and fluently into N
21
Please provide the text that needs to be translated accurately and fluently into O
19
Please provide the text that needs to be translated accurately and fluently into
Molecular weight: 1646.85 Da
Properties: White freeze-dried powder, excellent water solubility, colorless clear liquid after reconstitution; Acetate is the common medicinal form
Quality control: RP-HPLC ≥ 98.0%, impurity ≤ 0.5% (research standard for raw materials)
Storage: Dry powder - Store in a sealed container at 20℃, protected from light; Solution preparation - Store at 2-8℃, and avoid repeated freezing and thawing

Items	Specifications
name	Melanotan I
Purity	99%
Appearance	White powder

Melanotan I, also known as afamelanotide, is a synthetic linear 13-mer peptide with the sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂. This peptide is a stabilized analog of the naturally occurring α-melanocyte-stimulating hormone (α-MSH), designed to resist enzymatic degradation while retaining high selectivity for melanocortin receptors, particularly MC1R. The incorporation of norleucine (Nle) at position 4 and D-phenylalanine (D-Phe) at position 7, along with N-terminal acetylation and C-terminal amidation, significantly enhances its stability and half-life compared to native α-MSH, making it a valuable tool for in vitro and in vivo laboratory research.

The molecular weight of Melanotan I is 1646.85 Da, and it is most commonly supplied as the acetate salt form, which offers improved stability and water solubility. In its lyophilized state, Melanotan I appears as a white to off-white freeze-dried powder, with excellent aqueous solubility; when reconstituted in sterile water or appropriate buffers, it forms a colorless, clear solution. This solubility profile allows for straightforward integration into a wide range of experimental protocols, from cell culture assays to in vivo animal studies.

Quality control for Melanotan I is strictly maintained to meet research-grade standards, with RP-HPLC purity typically ≥98.0% (often reaching 99% as specified in product specifications) and total impurities limited to ≤0.5%. Each batch undergoes rigorous testing, including mass spectrometry to confirm molecular weight, HPLC to verify purity, and endotoxin testing to ensure levels are sufficiently low for sensitive biological assays. These quality measures are critical to ensure reproducibility and reliability in experimental results, eliminating confounding variables from contaminants.

Proper storage is essential to preserve the integrity and activity of Melanotan I. In its lyophilized form, the powder should be stored in a sealed, light-protected container at -20°C (-4°F) in a dry environment, away from moisture and direct sunlight. Under these conditions, the unopened product remains stable for up to 24 months from the date of manufacture. Once reconstituted, the solution should be stored at 2–8°C (refrigerated) and used within 30 days to prevent degradation. Repeated freeze-thaw cycles of the reconstituted solution should be avoided, as they can cause peptide denaturation and loss of biological activity. For long-term storage of reconstituted material, aliquoting the solution into small volumes and freezing at -20°C is recommended, though activity may gradually decrease with each cycle.

The biological activity of Melanotan I is centered on its role as a potent and selective agonist of the MC1R receptor, a G-protein coupled receptor (GPCR) expressed primarily on melanocytes, keratinocytes, and immune cells. Activation of MC1R by Melanotan I triggers intracellular signaling cascades that stimulate melanin synthesis, a process widely studied in the context of pigmentation research. Additionally, MC1R activation has been linked to anti-inflammatory and photoprotective effects in preclinical models, making Melanotan I a useful tool for investigating these pathways in controlled laboratory settings. Unlike native α-MSH, which is rapidly degraded by peptidases in biological fluids, Melanotan I’s modified structure confers resistance to enzymatic breakdown, allowing for sustained receptor activation and more consistent experimental outcomes.

In laboratory research applications, Melanotan I is utilized across a variety of study designs. In vitro, it is employed to investigate MC1R signaling pathways in melanocyte and keratinocyte cell cultures, evaluating parameters such as melanin production, gene expression, and cellular proliferation. These studies help to elucidate the molecular mechanisms underlying pigmentation and the role of MC1R in skin biology. In vivo, Melanotan I is used in animal models to explore systemic effects, including skin pigmentation responses, photoprotection against UV-induced damage, and potential anti-inflammatory properties. The compound’s well-characterized pharmacokinetic profile in preclinical models, including absorption, distribution, metabolism, and excretion, allows researchers to design experiments with precise dosing and administration protocols, ensuring accurate interpretation of results.

Manufacturing processes for Melanotan I adhere to strict quality control guidelines, utilizing solid-phase peptide synthesis (SPPS) to assemble the amino acid sequence with high precision. The synthesis begins with the coupling of protected amino acids to a solid resin support, followed by stepwise elongation of the peptide chain. After assembly, the peptide is cleaved from the resin, and protecting groups are removed, yielding the crude peptide. Purification via reverse-phase high-performance liquid chromatography (RP-HPLC) removes impurities and byproducts, resulting in the high-purity final product. The peptide is then lyophilized under aseptic conditions to produce the stable, freeze-dried powder form suitable for laboratory use.

Safety considerations are paramount when handling Melanotan I in a laboratory environment. As a research chemical, it must be handled only by trained personnel wearing appropriate personal protective equipment (PPE), including nitrile gloves, safety goggles, and a lab coat. Work should be conducted in a certified fume hood or biosafety cabinet to prevent inhalation of dust or aerosols. Skin and eye contact with the powder or reconstituted solution should be avoided, and any spills should be contained and cleaned up immediately using appropriate absorbent materials, with waste disposed of in accordance with institutional hazardous chemical waste protocols. While preclinical studies have demonstrated good tolerability in animal models at research doses, Melanotan I is not approved for human or veterinary use, and no therapeutic claims are made regarding its safety or efficacy outside of controlled laboratory research.

The versatility of Melanotan I as a research tool extends to its compatibility with a range of solvents and buffers. It readily dissolves in sterile water for injection, 0.9% sodium chloride solution, and common laboratory buffers such as phosphate-buffered saline (PBS) at physiological pH (5.0–7.5). Solvents with extreme pH levels (below 3 or above 9) should be avoided, as they can accelerate peptide degradation. When reconstituting, it is recommended to add the solvent slowly along the inner wall of the vial to minimize foaming, which can denature the peptide. Gentle swirling, rather than vortexing, is preferred to ensure complete dissolution without compromising structural integrity.

Quality assurance measures for each batch of Melanotan I include the provision of a Certificate of Analysis (COA), which details batch-specific test results, including HPLC purity, mass spectrometry confirmation, endotoxin levels, and residual moisture content. This documentation ensures full traceability from manufacturing to distribution, allowing researchers to verify the quality and consistency of the product they receive. Additionally, third-party testing is often conducted to confirm purity and identity, providing an extra layer of confidence in the product’s suitability for research use.

In summary, Melanotan I is a well-characterized, high-purity research peptide with applications in pigmentation biology, MC1R signaling, and photoprotection research. Its modified structure, enhanced stability, and selective receptor agonist activity make it a reliable tool for investigating biological pathways related to melanin synthesis and MC1R function. With strict quality control, clear handling and storage protocols, and compatibility with standard laboratory workflows, Melanotan I supports reproducible and rigorous preclinical research, contributing to the advancement of scientific understanding in skin biology and related fields.

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ECHEMI Editorial Reference

ChEBI: Afamelanotide is a polypeptide comprising of 13 amino acids which is an analogue of alpha-melanocyte stimulating hormone. It is approved as a dermatologic drug for the prevention of phototoxicity in adult patients with erythropoietic protoporphyria. It has a role as a dermatologic drug.
Melanotan-1 stimulating hormone is a potent analogue of α;-melanocyte-stimulating hormone (α -MSH). αMSH is a tridecapeptide, mostly produced by the cells in the brain, pituitary and in circulation.

Research & Reference Note

Purity 99% - Customization available Melanotan I 10mg*10vials is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

Authoritative sources

Disclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

Reviewed by ECHEMI Scientific Review - Platform editorial review for research chemicals

Certificates

Basic Info

Product Name:

Melanotan-1

Other Name:

[NLE4,D-PHE]ALPHA-MELANOCYTE STIMULATING HORMONE;(NLE4,D-PHE7)-ALPHA-MSH;[Nle4,D-Phe7]α-MSH;Ac-L-Ser-L-Tyr-L-Ser-L-Nle-L-Glu-L-His-D-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2;N-Ac-L-Ser-L-Tyr-L-Ser-L-Nle-L-Glu-L-His-D-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2;[Nle4,DPhe7] a-MSH, amide;[Nle4,DPhe7] a-MSH, amide:Melanotan Ⅰ;[Nle4, D-Phe7]-α-MSH, amide

CAS No.:

75921-69-6

Molecular Formula:

C78H111N21O19

InChIKeys:

UAHFGYDRQSXQEB-LEBBXHLNSA-N

Molecular Weight:

1646.85

EC Number:

211-519-9

Color/Form:

White to off-white

Categories:

Polypeptide

Characteristics

Density:

1.46±0.1 g/cm3(Predicted)

Water Solubility:

Soluble to 0.60 mg/ml in sterile water

PKA:

4.43±0.10(Predicted)

Critical Temperature & Pressure:

−20°C

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Melanotan-1 Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Semag lutide,Tirzepatide,Retatrutide,raw material,GHK-CU,TB500(Thymosin B4 AceTate)

Location:
Room 1002-C3973, No. 80, Yongtai Modaonan Street, Yongping Subdistrict, Baiyun District, Guangzhou City

Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
45 days

Year of Establishment:
2026

Anymang is a US-based trading company dedicated to the global supply and formulation of high-quality cosmetic raw materials, with a core focus on peptide ingredients. Committed to bridging premium suppliers and beauty manufacturers worldwide, we deliver pure, stable, and efficacious peptides—including anti-aging, brightening, and firming peptides—alongside a full spectrum of cosmetic actives and custom formulation solutions. With rigorous quality control and compliance with US safety standards, we ensure consistent batch quality and reliable delivery. Our experienced team provides professional technical support and tailored services to help clients develop competitive skincare and personal care products. Trusted by partners across the globe, Anymang stands as your dependable partner for innovative, high-performance cosmetic raw materials and peptide formulations.
Weekly Price

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Inquiry History

19 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	ACE031, ACVR2B CAS 75921-69-6 99.9% White powder qiancheng	500	Dec 16, 2023
China	High Purity Melanotan -1 Peptide CAS 75921-69-6 Lyophilized powder 10mg/vial 10vials/box	1 MT	Jun 29, 2026
Germany	Melanotan	2 G	Sep 16, 2026
United States	Melanotan 1	20 MG	Jul 1, 2026
Denmark	Melanotan 1	10 MG	Jun 1, 2026
Denmark	Melanotan - 1	10 PCS	May 31, 2026
United States	Melanotan 1	6 MT	Apr 19, 2026
United States	Melanotan 1	10 MG	Apr 2, 2026
United States	Melanotan 1	10 G	Apr 1, 2026
Poland	Retatrutide 50mg lyophilized powder in stock	50 MG	Feb 20, 2026
Thailand	Melanotan 1	1 PCS	Feb 7, 2026
Pakistan	Melanotan-1	20 MG	Jan 21, 2026
Sweden	Melanotan 1	1 KG	Jul 28, 2025
United States	mt1 and cjc 1925 with ipmorline and GHKCU and KLOW	20 MT	Oct 6, 2026
United States	MT1	5 MG	Nov 12, 2024
United Kingdom	Melanotan	1 KG	Sep 17, 2026
Australia	Melanotan 1	8 MT	Sep 15, 2024
China	High Purity Melanotan -1 Mt1 Peptide CAS 75921-69-6 Lyophilized powder 10mg/vial 10vials/box	1 MT	Jun 29, 2026
China	Lyophilized Peptide 99.9% Purity Melanotan I Powder Melanotan 1 Mt1 CAS 75921-69-6	1 MT	Jun 29, 2026

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Purity 99% - Customization available Melanotan I 10mg*10vials

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