KPV Manufacturer 99% Purity Bulk 5 mg 10mg 15mg

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Basic Info.

I. Basic Information

Full Name: Lysine-Proline-Valine

Abbreviation: KPV, Tripeptide-36, α-MSH (11-13)

CAS Number: 67727-97-3
Molecular Formula: C₁₆H₃₀N₄O₄
Molecular Weight: 342.43
Sequence: H-Lys-Pro-Val-OH
Source: Human natural α-melanocyte-stimulating hormone (α-MSH) C-terminal 11–13 active fragment, without pigmentation side effects

II. Mechanism of Action (Core: potent anti-inflammatory, non-pigmenting)

Inhibition of NF-κB pathway (main mechanism)

Blocking IκB kinase phosphorylation, preventing NF-κB nuclear translocation

Downregulating pro-inflammatory factors such as TNF-α, IL-1β, IL-6, and IL-8

Inhibiting NLRP3 inflammasome

Reducing Caspase-1 activation, blocking IL-1β/IL-18 maturation and release

Transported into cells via PepT1

High expression of PepT1 in the gut/inflamed tissues; orally effective with good bioavailability

Independent of melanocortin receptors (MC1R, etc.)

Anti-inflammatory activity comparable to α-MSH, but without the risk of skin darkening

III. Core Efficacy

Systemic anti-inflammatory: Relieves acute and chronic inflammation and autoimmune responses

Gut repair: Improves inflammatory bowel disease (IBD), leaky gut, and protects the mucosal barrier

Skin repair: Anti-inflammatory, promotes healing, and improves sensitivity/acne/psoriasis

Metabolic support: Helps improve obesity-related inflammation and insulin resistance

Antibacterial: Inhibits Staphylococcus aureus and Candida albicans

IV. Dosage Form and Usage (Research/Experimental)

Common dosage form: Lyophilized powder

Storage: Store at -20℃; after reconstitution, refrigerate and protect from light; use within 1–2 weeks.

Packaging & Shipping   

------FAQ------

Is tirzepatide available for weight loss?

It's also FDA approved for chronic weight management in adults with or without diabetes. Along with diet and exercise, tirzepatide can lead to significant weight loss — an average of 15% to 20% (34 lbs to 48 lbs). But tirzepatide for weight loss is only recommended for people who meet certain BMI criteria.

How fast do you lose weight on tirzepatide?

How quickly you lose weight depends on factors like lifestyle habits, diet, activity level, age, and other medications you may be taking. However, most people who follow a healthy diet and exercise routine begin reporting some weight loss within a month to two months of starting the medication.

Which payment is available for your company?

Bank Transfer,Paypal or Bitcoins usdt trc usdt erc and so on.  You can choose the way which is convenient for you.

May I get one sample before placing order?

Yes, Sample are available. For normal products, samples are for free and you just need to bear the freight; For those high value products, you just need to freight and certain product cost. When we both cooperate for some times or when you are our VIP customer, free sample will be offered when you need.Mutual effort towards each other.

Why should you buy from us not from other suppliers?

1. Powerful R & D team
2. The ability of quantized production from grams to tons;
3. Various kinds of advanced equipment in the laboratory and plant;
4 .Strict QC standard to meet the demand of customers, advanced equipment for analysis and assay;
5. Efficient and safe logistic plans for chemical products transportation;
6 .Excellent after-sale service.
7. Highest quality and good package
8 .ISO certificate