Dynorphin A (1-13) CAS 72957-38-1 High Purity for Research

Dynorphin A (1-13）CAS 72957-38-1 High Purity for Research

Basic properties of Dynorphin A (1-13): the molecular formula is CHNO, and the molecular weight is about 1610.87 Da；; It belongs to the endorphin family and is a linear polypeptide. It is hydrophobic, soluble in organic solvents , and soluble in water. The stability is greatly influenced by pH and temperature, and it is stable under neutral conditions, and easy to degrade under high temperature or extreme pH environment.

Application field of Dynorphin A (1-13)
1. Research field of neuroscience: As an important member of endogenous opioid peptides, it is widely used in the functional research of central nervous system (CNS), including basic research in pain regulation, emotional regulation, learning and memory mechanisms, and is a key tool reagent for exploring opioid receptor-mediated neural signal pathways.

2. Drug research and development field: used for screening and evaluation of opioid receptor antagonists and agonists, providing target verification and activity detection basis for the research and development of new analgesic drugs, anti-anxiety drugs and anti-addiction drugs.

3. Auxiliary research of clinical diagnosis: it is used to study the pathogenesis of diseases related to abnormal dynorphin A(1-13) levels, such as chronic pain, depression, epilepsy, Parkinson's disease and other neurodegenerative diseases and psychiatric diseases.

4. Pharmacology research field: It is used to explore the interaction between opioid peptide system and other neurotransmitter systems (such as dopamine and serotonin systems), and provide experimental support for elucidating complex neurophysiological and pathological processes.

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Omizzur peptide is supplying salmon calcitonin and various related peptide impurities, which are mainly used in scientific research and experiments. Most products are in stock. If there are special requirements, they need to be customized. The customization is about 2-3 weeks. Omizzur provides a complete analysis report. (HPLC,MS,COA)

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Dynorphin A (1-13) R&D related applications

1. Research and development of analgesic drugs: Traditional opioid analgesic drugs (such as morphine) mainly act on μ-opioid receptors, which are easy to produce side effects such as addiction and respiratory depression. Dynorphin A (1-13) specifically acts on KOR, which provides a target direction for developing new analgesic drugs with low addiction and high selectivity. Based on its structure, KOR agonist analgesic candidate drugs with higher stability and better bioavailability can be developed by modifying the polypeptide sequence (such as cyclization and amino acid substitution).

2. Research and development of antipsychotic drugs: It is found that the activation of KOR is closely related to emotional disorders such as anxiety and depression, and the abnormal increase of Dynorphin A (1-13) level may aggravate depression-like behavior. Therefore, the research and development of KOR antagonists or inverse agonists based on its action pathway is expected to become new drugs for the treatment of depression and anxiety. At present, a number of such candidate drugs have entered the preclinical research stage.

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The purity of Omizzur polypeptide API is mainly ensured by strict quality control procedures, including raw material screening, process optimization and analysis and detection.

In the process of synthesis, we will monitor the impurities such as missing peptides and inserted peptides, and use high performance liquid chromatography (HPLC) to separate and quantify them.

In addition, Omizzur will also compare synthetic reference materials to ensure that hidden impurities such as optical isomers can also be accurately identified and controlled.

Stability test is also the key, because peptides are easily affected by temperature and humidity, so it is necessary to monitor the degradation risk throughout.

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