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5C-aglycone

Name: 5C-aglycone
Brand: Cuicheng Bio
SKU: pr2606081181
Price: 1000 USD
Availability: InStock

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CAS No.:

34927-45-2

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

1mg

Price valid (until):

2026-07-08

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Description

5C-aglycone (chemically known as 2-methyl-3-(3'-carboxybutyl)-1,4-naphthoquinone; CAS 34927-45-2) functions primarily as a major urinary biomarker for assessing human vitamin K status and tracking hepatic lipid oxidation.

It is one of the two primary, water-soluble end metabolites—alongside 7C-aglycone—produced when the body processes and breaks down vitamin K₁ (phylloquinone) and vitamin K₂ (menaquinones).

Core Functions and Biological Roles

Primary Biomarker for Vitamin K Intake: In clinical nutrition and epidemiology, 5C-aglycone functions as an indispensable marker to evaluate global vitamin K status. Because it accounts for roughly 75% of total urinary vitamin K excretion, its levels drop sharply during dietary restriction and surge immediately following vitamin K replenishment.
End-Product of Side-Chain β-Oxidation: Structurally, it serves as proof of hepatic lipid processing. When vitamin K enters the liver, enzymes initiate omega-oxidation ($\omega $-oxidation) followed by sequential rounds of beta-oxidation ($\beta $-oxidation). This pathway progressively strips down the long, hydrophobic phytyl or isoprenoid side chains attached to the naphthoquinone ring until a shortened, 5-carbon carboxylic acid tail remains.
Substrate for Phase II Detoxification: To facilitate excretion from the body, 5C-aglycone functions as a metabolic substrate for glucuronidation. The liver conjugates it with glucuronic acid to drastically increase its water solubility, allowing it to pass harmlessly through the kidneys into the urine.
Neonatal Prophylaxis Monitoring: In clinical pediatrics, monitoring urinary 5C-aglycone excretion facilitates longitudinal tracking of vitamin K stores in newborns. Because infants are born with precariously low vitamin K levels, measuring this metabolite helps clinicians optimize prophylactic dosing regimens to prevent Vitamin K Deficiency Bleeding (VKDB).
Therapeutic Screening Target: Beyond acting as a waste marker, its parent compound forms are utilized as supplementary treatments for systemic conditions like bone density management in osteoporosis. Emerging clinical studies also analyze changes in 5C-aglycone ratios to evaluate lipid metabolic dysregulation in rare calcification disorders like Pseudoxanthoma elasticum (PXE).

Basic Info

Product Name:

1,4-Dihydro-α,3-dimethyl-1,4-dioxo-2-naphthalenebutanoic acid

Other Name:

2-Naphthalenebutanoic acid,1,4-dihydro-α,3-dimethyl-1,4-dioxo-;1,4-Dihydro-α,3-dimethyl-1,4-dioxo-2-naphthalenebutanoic acid;2-Methyl-3-(3′-carboxybutyl)-1,4-naphthoquinone;2-Methyl-3-(3-carboxybutyl)-1,4-naphthoquinone

CAS No.:

34927-45-2

Molecular Formula:

C16H16O4

InChIKeys:

InChIKey=ALLYVKRLOHDVKI-UHFFFAOYSA-N

Molecular Weight:

272.29584

Exact Mass:

272.30

HScode:

2918300090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

71.4

XLogP3:

2.5

Appearance:

Solid

Density:

1.234g/cm3

Boiling Point:

472.4ºC at 760mmHg

Flash Point:

253.6ºC

Refractive Index:

1.569

See More 1,4-Dihydro-α,3-dimethyl-1,4-dioxo-2-naphthalenebutanoic acid Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 1,4-Dihydro-α,3-dimethyl-1,4-dioxo-2-naphthalenebutanoic acid Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

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5C-aglycone

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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