PNC-27 anti-cancer peptide, supplied by the manufacturer, with favorable price.

PNC-27, an anticancer peptide, containing an HDM-2 binding domain corresponding to p53 residues 12-26 and a transmembrane penetrating domain, has been found to kill cancer cells but not normal cells by inducing membrane lysis. The 3D structure of the p53 residue of PNC-27 directly overlaps the structure of the same residue that binds HDM-2, suggesting that this peptide may target HDM-2 in the cell membrane. The researchers found significant levels of HDM-2 in the cell membranes of a variety of cancer cells but not in some untransformed cell lines. In colocalization experiments, PNC-27 bound to cell membrane-bound HDM-2. The researchers used a membrane localization signal to transfect a plasmid expressing full-length HDM-2 into PNC-27-insensitive untransformed MCF-10-2A cells and found that these cells expressed full-length HDM-2 on their cell surface. cells versus PNC-27. We concluded that PNC-27 targets HDM-2 in cancer cell membranes, allowing it to selectively induce membrane lysis in these cells.

FAQ

Q1:Are you a supplier or a manufacturer?

A:We are both a supplier and a manufacturer.

Q2:How will you deliver the goods?

A:We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air Post. For container products, we can do sea shipping. You also can choose your own shipping forwarder.

Q3:Which kind of payment terms do you accept?

A:, Bitcoin, PayPal.USDT.

Q4:How is the after-sales service?

A:We will provide high-quality products and ensure 100% safe deliver.

Q5:how can we guarantee quality?

A:We will send you a COA (Certificate of Analysis) to you first for you to confirm the quality.

Q6: How to confirm the Product Quality before placing orders?

A:You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q7:Is there any discount?

A:Yes, for larger quantity, we always support with better pric e

Why Choose Us:  

Fast Delivery: We ship your order quickly using DHL, FedEx, and other options. Most orders arrive in 5-15 days.

Customs Clearance: No customs problems! We make sure your order is delivered smoothly.

Easy Payment: Pay with Bitcoin,USDT,PAYAPL, or bank transfer.

Good Quality: Our products are great, and we support small test orders.

Company advantages ;

Are you from these countries?United States, Canada, Spain, Portugal, Australia, Brazil, France, Netherlands, United Kingdom, Bulgaria, Norway, and more.

Good News! We guarantee smooth customs clearance in key destinations, including Germany and Finland, with no issues at all. Your packages will be securely delivered within 5-15 days.

Company Introduction

Shanxi An Da Si Hai Technology Co., Ltd. is a professional manufacturer of various peptide products and chemical raw materials.

We have a dedicated R&D team and a reliable, efficient logistics team to ensure you receive high-quality products safely and promptly.In order to serve customers well, the company has established special technical department and after-sale service department. Our customers come from countries including the United States, Europe,

Europe, Japan, South Korea, and India. Most of our main products are in stock and ready for immediate shipment.  Please let us know the specific quantity you need.

We will make careful reply if you get any question. We will satisfy market demands by top products and better service, and will welcome market challenge .We will offer you the most competitive price. Feel free to contact us for more information.