Hot Selling OPICAPONE 923287-50-7 Factory Supply Raw Materials High Qulity Wholesale price
TDS
923287-50-7
Pharmaceutical Grade
99.9%
shanghai
BOCARE
25kg/Cardboard Drum
2026-04-10
pregabalin,Tirzepatide,Retatrutide,Food Additives,semaglutide,Cosmetics material
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceOpicapone is a ring assembly and an oxadiazole.|Opicapone is a potent, reversible, and peripherally-acting third-generation inhibitor of catechol-o-methyltransferase (COMT), an enzyme involved in the breakdown of various catecholamines including dopamine. In June 2016, the European Commission granted a marketing authorization valid throughout the European Union for OPC, indicated as adjunct therapy to levodopa and decarboxylase inhibitors in adult patients with Parkinson's disease and end-of-dose motor fluctuations. In April 2020, the FDA approved the use of opicapone as adjunctive treatment to levodopa/carbidopa in patients with Parkinson’s disease (PD) experiencing “off” episodes. Opicapone is marketed as, under the brand name Ongentys as once-daily oral capsules. Almost all individuals with Parkinson’s disease whom are treated with levodopa plus a dopa decarboxylase (DDC) inhibitor (eg carbidopa) will develop motor complications in time. The initial step in the management is changing the levodopa/DDC inhibitor dosage and the use of adjunct drugs. Various options include supplementing with a dopamine agonist, a monoamine oxidase B inhibitor (selegiline, rasagiline), a catechol-O-methyl transferase (COMT) inhibitor, or amantadine, or using a modified-release formulation of levodopa. The newest adjunctive option is opicapone. This drug is a peripherally selective reversible COMT inhibitor that offers the benefit of a duration of action exceeding 24h, allowing for once-daily administration. Opicapone demonstrates the lowest risk for cytotoxicity in comparison with other catechol-O-methyltransferase inhibitors.|Opicapone is a Catechol-O-Methyltransferase Inhibitor. The mechanism of action of opicapone is as a Catechol O-Methyltransferase Inhibitor.CertificatesBasic Info
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Product Name:
Opicapone
Other Name:1,2-Benzenediol,5-[3-(2,5-dichloro-4,6-dimethyl-1-oxido-3-pyridinyl)-1,2,4-oxadiazol-5-yl]-3-nitro-;5-[3-(2,5-Dichloro-4,6-dimethyl-1-oxido-3-pyridinyl)-1,2,4-oxadiazol-5-yl]-3-nitro-1,2-benzenediol;Opicapone;BIA 9-1067;5-[3-(2,5-Dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-3-nitrobenzene-1,2-diol;Ongentys;2,5-Dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine 1-oxide;1206590-61-5
CAS No.:923287-50-7
Molecular Formula:C15H10Cl2N4O6
InChIKeys:InChIKey=ASOADIZOVZTJSR-UHFFFAOYSA-N
Molecular Weight:413.16900
Exact Mass:413.17
UNII:Y5929UIJ5N
ATC Code:N04|N - Nervous system
Categories:
Characteristics-
PSA:
150.66000
XLogP3:4.59830
Density:1.80±0.1 g/cm3 (20 °C, 760 mmHg)
Boiling Point:701.1±70.0 °C (760 mmHg)
Water Solubility:minimal
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Seller Information
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Business Type:
Trader
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Main Products:
pregabalin,Tirzepatide,Retatrutide,Food Additives,semaglutide,Cosmetics material
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Location:
Jiuzhen Town, Tianmen City, Hubei Province
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Payment Terms:
TT against copy of documents,L/C,100% TT in advance
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Average lead Time:
7
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Total Annual Revenue:
$50 million-$100 million
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Total Employees:
101-200
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Year of Establishment:
2025
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
