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Propylamine107-10-8

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CAS No.:

107-10-8

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

上海

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-07-16

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Qingdao Orient Chemical Co.,LTD

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Trader

Location:

China

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pharmaceutical intermediates,peptides,electronic chemicals

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Description

Product Detail

Propylamine Basic information

Product Name:	Propylamine
Synonyms:	1-Aminopropan;1-Amino-propan;1-Propylamine;Monopropylamine;n-C3H7NH2;Propanamine;Propylamin;n-Propylaminwe
CAS:	107-10-8
MF:	C3H9N
MW:	59.11
EINECS:	203-462-3
Product Categories:	Alkylamines;Monofunctional & alpha,omega-Bifunctional Alkanes;Monofunctional Alkanes;bc0001;T0001;KT00001
Mol File:	107-10-8.mol

Propylamine Chemical Properties

Melting point	-83 °C (lit.)
Boiling point	48 °C (lit.)
density	0.719 g/mL at 25 °C (lit.)
vapor density	2 (vs air)
vapor pressure	4.79 psi ( 20 °C)
refractive index	n20/D 1.388(lit.)
FEMA	4237 \| PROPYLAMINE
Fp	−35 °F
storage temp.	Store below +30°C.
solubility	water: soluble0.4 part(lit.)
pka	10.6(at 20℃)
form	Liquid
color	Clear colorless to pale yellow
Specific Gravity	0.7173
PH	12.6 (100g/l, H2O, 20℃)
Odor	ammoniacal
Odor Threshold	0.061ppm
Odor Type	ammoniacal
biological source	human blood
explosive limit	2.1-13.6%(V)
Water Solubility	soluble
Sensitive	Air Sensitive
Merck	14,7843
JECFA Number	1580
BRN	1098243
Henry's Law Constant	6.6×10^-1 mol/(m³Pa) at 25℃, Burkholder et al. (2019)
Exposure limits	No exposure limit has been set. Based on its similarity to ethylamine in irritation and toxicity, a TLV-TWA of 10 ppm (～24 mg/m³) should be appropriate. .
Dielectric constant	3.0（Ambient）
Stability:	Stable. Highly flammable. Note low flash point. Readily forms explosive mixtures with air. Incompatible with oxidising agents, strong acids. Store cool.
InChI	1S/C3H9N/c1-2-3-4/h2-4H2,1H3
InChIKey	WGYKZJWCGVVSQN-UHFFFAOYSA-N
SMILES	CCCN
LogP	0.55
CAS DataBase Reference	107-10-8(CAS DataBase Reference)
NIST Chemistry Reference	1-Propanamine(107-10-8)
EPA Substance Registry System	Propylamine (107-10-8)

Safety Information

Hazard Codes	F,C
Risk Statements	11-20/21/22-34-35-52/53
Safety Statements	26-36/37/39-45-16-7/9-36-61
RIDADR	UN 1277
WGK Germany	1
RTECS	UH9100000
F	34
Autoignition Temperature	604 °F
TSCA	TSCA listed
HS Code	2921 19 99
HazardClass	3
PackingGroup	II
Storage Class	3 - Flammable liquids
Hazard Classifications	Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 4 Oral Eye Dam. 1 Flam. Liq. 2 Met. Corr. 1 Skin Corr. 1B STOT SE 3
Hazardous Substances Data	107-10-8(Hazardous Substances Data)
Toxicity	LD50 orally in rats: 0.57 g/kg (Smyth)

Propylamine Usage And Synthesis

Chemical Properties	n-Propylamine, also known as propylamine, is a colorless liquid with a pungent odor resembling ammonia. It has strong basic properties, leading to its easy formation of salts when combined with acids. Its reactivity is similar to that described for the other short chain aliphatic amines (Astel 1961).
Uses	n-Propylamine is used as an intermediate inmany organic reactions. It has been used in the synthesis of single crystals of siliceous ferrierite.
Uses	1-Propylamine is used in chemical analysis and to make other chemicals, used as a solvent in organic synthesis. And it is used as finishing agent of drugs, paints, rubber, fiber, textile and resin. Additionally, it can be used as petroleum additive and preservative.
Definition	ChEBI: Propylamine is a member of the class of alkylamines that is propane substituted by an amino group at C-1. It is a conjugate base of a propan-1-aminium.
Production Methods	There are several methods employed in the manufacture of propylamine. Typically, ammonia and propanol are reacted over a dehydration catalyst at high temperature and pressure. Ammonia, propanol, and hydrogen can also be reacted over a dehydrogenation catalyst such as metallic silver. Propylamine can also be synthesized from propionaldehyde and ammonia with a Raney nickel catalyst (Schweizer et al 1978).
Aroma threshold values	High strength odor; ammoniacal type; recommend smelling in a 0.10% solution or less.
General Description	A clear colorless liquid with an ammonia-like odor. Flash point -35°F. Less dense than water and soluble in water. Vapors are heavier than air. Produces toxic oxides of nitrogen during combustion. Used in chemical analysis and to make other chemicals.
Air & Water Reactions	Highly flammable. Slightly soluble in water.
Reactivity Profile	Colorless, alkaline liquid, very volatile (b. p. 48° C), moderately toxic, highly flammable. Dangerous fire hazard when exposed to heat, flame, sparks, or strong oxidizers. When heated to decomposition Propylamine emits toxic fumes of oxides of nitrogen. Incompatible with triethylaluminum, complex may explode on sublimation [Chini, P. et al., Chim. e Ind (Milan), 1962, 44, p. 1220].
Hazard	Highly flammable, dangerous fire risk, explosive limits in air 2–10%, use alcohol foam to extinguish. Strong irritant to skin and tissue.
Health Hazard	n-Propylamine is a strong irritant and a mod erately toxic substance. the toxic routes areinhalation, ingestion, and absorption throughthe skin. Contact of the liquid on the skincan cause burns and possibly skin sensitization. Irritation in the eyes from exposure tohigh concentrations can be severe. It is a respiratory tract irritant, similar to ethylamine.Inhalation of 2300 ppm of n-propylamine for4 hours caused labored breathing, hepatitis,and hepatocellular necrosis in rats. It is somewhat less toxic than ethylamine by oral anddermal routes. LC50 value, inhalation (mice): 2500 mg/m³/2 hr LD50 value, oral (rats): 570 mg/kg LD50 value, skin (rabbits): 560 mg/kg.
Fire Hazard	Highly flammable liquid; flash point (closed cup) -37°C (-35°F); vapor density 2.0 (air = 1), vapor can travel a considerable distance to a source of ignition and flash back; autoignition temperature 318°C (604°F); fire extinguishing agent: dry chemical, CO2, or “alcohol” foam; water should be used to keep fire-exposed containers cool and to flush and dilute the spill. n-Propylamine forms explosive mixtures in air; LEL and UEL values are 2.0% and 10.4% by volume in air, respectively. There is no report of explosion associated with this compound. It is expected to exhibit violent reactions characteristic of lower aliphatic primary amines .
Industrial uses	Propylamine is important as a chemical intermediate for rubber chemicals, dyestuffs, propyl isocyanate, textile and leather finishing resins and corrosion inhibitors. It is also used in the production of pharmaceuticals such as Prilocaine, pesticides including Profluralin and in petroleum additives. In 1976, 500 tons of propylamine were manufactured in the U.S. (HSDB 1988).
Safety Profile	Moderately toxic by inhalation, ingestion, and skin contact routes. A skin and severe eye irritant. Possibly a skin sensitizer. Very dangerous fire hazard when exposed to heat, flame, or oxidizers. Explosive in the form of vapor when exposed to heat or flame. To fight fire, use alcohol foam. When heated to decomposition it emits toxic fumes of NOx. Incompatible with triethynyl aluminum. See also AMINES.
Potential Exposure	Propylamine is used to make textile resins, drugs, pesticides, and other chemicals.
Metabolism	To date, there are several studies which indicate that propylamine may be metabolized in many animal species, including man. When propylamine hydrochloride was administered to humans orally, little of the parent compound was recovered in the urine (Rechenberger 1940). It has also been reported that dogs are capable of metabolizing propylamine (Bernhard 1938). McEwen et al (1966) demonstrated that monoamine oxidase, purified from rabbit serum, was capable of oxidizing propylamine, although less actively than substituted phenylethylamines such as dopamine. Further characterization revealed that the protonated amine is bound by an unprotonated enzyme group, that the enzyme active site is composed of hydrophobic residues, and that interaction of the amine residues determines maximal velocity and affinity constant (McEwen and Sober 1967). Oxidation of the amine could be stimulated by the presence of aliphatic alcohols which apparently bond in a tertiary complex with the enzyme and substrate, thereby increasing the effectiveness of substrate binding. Other investigators have provided evidence that propylamine may not be a substrate for tissue monoamine oxidase. When given intraperitoneally to rats it had no effect on the liver enzyme and little effect on activity in the brain (Valiev 1974). Early work by Pugh and Quastel (1937) indicated that slices of rat brain did not metabolize propylamine.
Shipping	UN1277 Propylamine, Hazard Class: 3; Labels: 3-Flammable liquid, 8-Corrosive material.
Purification Methods	Distil the amine from zinc dust, under reduced pressure, in an atmosphere of nitrogen. [Beilstein 4 IV 464.]
Incompatibilities	Propylamine Vapors may form explosive mixture with air. Violent reaction on contact with oxidizers and mercury, strong acids; organic anhydrides; isocyanates, aldehydes, nitroparrafins, halogenated hydrocarbons; alcohols and many other compounds. Attacks many metals and alloys, especially those of copper. Aqueous solution is acidic and may attack glass.
Toxics Screening Level	The initial threshold screening level (ITSL) for propylarnine is 112 μg/m3 based on anannual averaging time.
Waste Disposal	Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

Propylamine Preparation Products And Raw materials

Raw materials

Aluminum oxide-->Acrylonitrile-->Propionaldehyde-->Dipropylamine-->1-Propanol-->2-Nitropropane-->N,N-Dipropyl-1-propanamine-->ALPHA-DIMETHYLAMINOPROPIONITRILE-->Tetramethyl-1,3-diaminopropane-->3,3'-IMINOBIS(N,N-DIMETHYLPROPYLAMINE)

Preparation Products

Molosultap-->Dipropylamine-->palladium catalyst supported by poly (2, 6-dimethyl-1, 4-phenylene oxide)-->4-Amino-3-pyridinecarboxylic acid-->N-Methylpropylamine-->N,N-Dipropyl-1-propanamine-->dimethyl dodecyl thioic propylene betaine-->trimethyl lauroylaminopropyl ammonium methylsulfate-->adhesive FWR-->cocoamide propyl amine oxide-->Roxatidine acetate-->N-[2-(2,4,6-trichlorophenoxy)ethyl]propylamine-->Prilocaine-->zeolite type ZSM-48-->TC-1 filler for leather surface

Shop 4-Aminopyridine504-24-5C5H6N2-Detailed Image 2 Shop Semaglutide 910463-68-2C187H291N45O59-Detailed Image 5

Basic Info

Product Name:

Propylamine

Other Name:

1-Propanamine;Propylamine;1-Aminopropane;Mono-n-propylamine;n-Propylamine;1-Propylamine;Monopropylamine;NSC 7490;Propan-1-ylamine;(n-Propan-1-yl)amine;3-Aminopropane;Propan-1-amine;42939-71-9

CAS No.:

107-10-8

Molecular Formula:

C3H9N

InChIKeys:

InChIKey=WGYKZJWCGVVSQN-UHFFFAOYSA-N

Molecular Weight:

59.11

Exact Mass:

59.11

BRN:

1098243

EC Number:

203-462-3

UNII:

I76F18D635

ICSC Number:

0941

NSC Number:

7490

UN Number:

1277

DSSTox ID:

DTXSID6021878

Color/Form:

Colorless liquid

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

XLogP3:

0.15

Appearance:

Clear colorless to pale yellow Liquid

Density:

0.719 g/cm³ @ Temp: 20 °C

Melting Point:

-83 °C

Boiling Point:

48-49 °C

Flash Point:

−35 °F

Refractive Index:

n20/D 1.388(lit.)

Water Solubility:

H2O: soluble

Storage Conditions:

0-6°C

Vapor Pressure:

4.79 psi ( 20 °C)

Vapor Density:

2 (vs air)

Toxicity:

Inhalation-rat LC50: 2310PPM/4 hours; inhalation-mouse LC50: 2500 mg/m3/2 hours

Flammability characteristics:

Inflammable in case of open flame, high temperature, oxidant; burning produces toxic nitrogen oxide fumes

Explosive limit:

2.1-13.6%(V)

Odor:

Strong ammonia odor

PH:

Alkaline

Henrys Law Constant:

1.48e-05 atm-m3/mole|Henry's Law constant = 1.48X10-5 atm-cu m/mole at 25 °C

Dissociation Constants:

pKa = 10.71 (conjugate acid)

Experimental Properties:

CONVERSION UNITS: 1 MG/L= 414 PPM; 1 PPM= 2.42 MG/CU M|VAPOR PRESSURE: 400 MM HG AT 31.5 °C|Hydroxyl radical reaction rate constant = 3.3X10-11 cu cm/molec-sec at 25 °C (est)

Air and Water Reactions:

Highly flammable. Slightly soluble in water.

Reactive Group:

Amines, Phosphines, and Pyridines

Reactivity Alerts:

Highly Flammable

Reactivity Profile:

Colorless, alkaline liquid, very volatile (b. p. 48° C), moderately toxic, highly flammable. Dangerous fire hazard when exposed to heat, flame, sparks, or strong oxidizers. When heated to decomposition it emits toxic fumes of oxides of nitrogen. Incompatible with triethylaluminum, complex may explode on sublimation [Chini, P. et al., Chim. e Ind (Milan), 1962, 44, p. 1220].

Autoignition Temperature:

604 °F (USCG, 1999)|604 °F (317 °C)|320 °C

Heat of Combustion:

-2365.3 kJ/mole at 25 °C (liquid)

Flammable Limits:

Lower flammable limit: 2% by volume; Upper flammable limit: 10.4% by volume

Physical Dangers:

The vapour is heavier than air and may travel along the ground; distant ignition possible.

Heat of Vaporization:

31.27 kJ/mol at 25 °C

Critical Temperature & Pressure:

Critical temperature: 497.0 K; critical pressure = 4.72 MPa

See More Propylamine Properties 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
Indonesia	PA	2 20' Fcl	Oct 17, 2023

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Propylamine107-10-8

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