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N-Methylpiperidine626-67-5

Name: N-Methylpiperidine626-67-5
Brand: OORENT
SKU: pr2606171534
Price: 33 USD
Availability: InStock

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CAS No.:

626-67-5

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

上海

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2027-11-09

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information

Description

Product Detail

N-Methylpiperidine Basic information

Product Name:	N-Methylpiperidine
Synonyms:	1-METHYLPIPERIDINE;N-METHYLPIPERIDINE;NMPPR;N-MEPIP;N-methylpepiridine;1-methyl-piperidin;lk20;Piperidine,1-methyl-
CAS:	626-67-5
MF:	C6H13N
MW:	99.17
EINECS:	210-959-9
Product Categories:	Piperidine;Building Blocks;Heterocyclic Building Blocks;Piperidines;Alphabetical Listings;Flavors and Fragrances;M-N
Mol File:	626-67-5.mol

N-Methylpiperidine Chemical Properties

Melting point	-50 °C
Boiling point	106-107 °C (lit.)
density	0.816 g/mL at 25 °C (lit.)
vapor pressure	35.7hPa at 20℃
refractive index	n20/D 1.438
Fp	38 °F
storage temp.	−20°C
solubility	Chloroform (Sparingly), Methanol (Slightly)
pka	10.08(at 25℃)
form	Liquid
color	Clear colorless
PH	12 (100g/l, H2O, 20℃)
biological source	synthetic
explosive limit	1.1-9.9%(V)
Water Solubility	miscible
BRN	1073
Henry's Law Constant	2.4×10^-1 mol/(m³Pa) at 25℃, Abraham et al. (1994)
Dielectric constant	2.5899999999999999
InChI	1S/C6H13N/c1-7-5-3-2-4-6-7/h2-6H2,1H3
InChIKey	PAMIQIKDUOTOBW-UHFFFAOYSA-N
SMILES	CN1CCCCC1
LogP	1.15 at 25℃
CAS DataBase Reference	626-67-5(CAS DataBase Reference)
NIST Chemistry Reference	Piperidine, 1-methyl-(626-67-5)
EPA Substance Registry System	Piperidine, 1-methyl- (626-67-5)

Safety Information

Hazard Codes	C,F,T
Risk Statements	11-34-20/22-39/23/24/25-23/24/25-67-22-10-37
Safety Statements	7-16-26-36/37/39-45-9-33
RIDADR	UN 2399
WGK Germany	3
RTECS	TN1225000
F	3-10
TSCA	TSCA listed
HazardClass	3
PackingGroup	II
HS Code	29333999
Storage Class	3 - Flammable liquids
Hazard Classifications	Acute Tox. 3 Inhalation Acute Tox. 4 Dermal Acute Tox. 4 Oral Aquatic Chronic 3 Eye Dam. 1 Flam. Liq. 2 Skin Corr. 1B
Toxicity	LD50 intraperitoneal in mouse: 400mg/kg

MSDS Information

Provider	Language
N-Methylpiperidine	English
SigmaAldrich	English
ACROS	English
ALFA	English

N-Methylpiperidine Usage And Synthesis

Description	This simple piperidine derivative has been obtained from Girgensohnia diptera Bge. It is optically inactive and furnishes a crystalline picrate, m.p. 15 I-2°C and a picrolonate, m.p. 226°C.
Chemical Properties	CLEAR COLOURLESS LIQUID
Uses	Reactant for: ·sp3 C-H Bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines ·One-pot synthesis of Z-cinnamic acids Reactant for synthesis of: ·Unsymmetrical ureas ·Antibacterial imidazolium, pyrrolidinium, and piperidinium salts ·C1-C16 segment of goniodomin A via palladium-catalyzed organostannane thioester coupling ·Multi-targeted inhibitors of insulin-like growth factor-1 receptor and members of ErbB-family receptor kinases
Uses	1-Methylpiperidine is a reactant for sp3 C-H Bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines, One-pot synthesis of Z-cinnamic acids. It is used in the synthesis of Unsymmetrical ureas, Antibacterial imidazolium, pyrrolidinium, and piperidinium salts, C1-C16 segment of goniodomin A via palladium-catalyzed organostannane thioester coupling.
Uses	Reactant for: sp3 C-H Bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines One-pot synthesis of Z-cinnamic acids Reactant for synthesis of: Unsymmetrical ureas Antibacterial imidazolium, pyrrolidinium, and piperidinium salts C1-C16 segment of goniodomin A via palladium-catalyzed organostannane thioester coupling Multi-targeted inhibitors of insulin-like growth factor-1 receptor and members of ErbB-family receptor kinases
General Description	A colorless liquid with the odor of pepper. Density 0.816 g / cm3 and flash point 38°F. May irritate skin and eyes. Vapors heavier than air. Used as a solvent and to make other chemicals.
Air & Water Reactions	Highly flammable. Soluble in water.
Reactivity Profile	N-Methylpiperidine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Health Hazard	May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire Hazard	Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Flammability and Explosibility	Highly flammable
Safety Profile	Poison by intraperitoneal and subcutaneous routes. A very dangerous fire hazard when exposed to heat or flame. When heated to decomposition it emits toxic fumes of NOx.
Toxics Screening Level	The Initial Threshold Screening Level (ITSL) for n-methylpiperidine is 8 μg/m3 based on an annual averaging time.
References	Jurashevskii, Stepanov,J. Gen. Chem. USSR, 9,2203 (1939)

N-Methylpiperidine Preparation Products And Raw materials

Raw materials	isopropyl DL-methionate hydrochloride-->N'-methylpentane-1,5-diamine-->1-METHYL-2-PIPERIDONE-->1-METHYL-1,2,3,6-TETRAHYDROPYRIDINE-->1-Methylpyridinium chloride-->5-Amino-1-pentanol-->N-Formylpiperidine
Preparation Products	Mepiquat chloride-->1-Propylpiperidine-->Mepiquat-->PIPERIDIN-1-YL-ACETIC ACID-->1-Ethylpiperidine-->1-Butyl-1-methylpiperidinium Bromide-->1-Butylpyrrolidine-->1-BUTYL-PIPERIDINE-->1-(2-CHLORO-4-NITRO-PHENYL)-PIPERIDINE

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ECHEMI Editorial Reference

CLEAR COLOURLESS LIQUID
1-methylpiperidine appears as a colorless liquid with the odor of pepper. May irritate skin and eyes. Vapors heavier than air. Used as a solvent and to make other chemicals.
1-methylpiperidine appears as a colorless liquid with the odor of pepper. May irritate skin and eyes. Vapors heavier than air. Used as a solvent and to make other chemicals.

Basic Info

Product Name:

N-Methylpiperidine

Other Name:

Piperidine,1-methyl-;1-Methylpiperidine;N-Methylpiperidine;139252-84-9

CAS No.:

626-67-5

Molecular Formula:

C6H13N

InChIKeys:

InChIKey=PAMIQIKDUOTOBW-UHFFFAOYSA-N

Molecular Weight:

99.17410

Exact Mass:

99.17

EC Number:

210-959-9

UNII:

617374QZN4

UN Number:

2399

DSSTox ID:

DTXSID8060822

HScode:

29333999

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

3.24000

XLogP3:

1.04000

Appearance:

1-methylpiperidine appears as a colorless liquid with the odor of pepper. May irritate skin and eyes. Vapors heavier than air. Used as a solvent and to make other chemicals.

Density:

0.8142 g/cm³ @ Temp: 23 °C

Melting Point:

106-107 °C

Boiling Point:

107 °C

Flash Point:

38 °F

Refractive Index:

n20/D 1.438

Water Solubility:

miscible

Storage Conditions:

-20ºC

Vapor Pressure:

19.36 mmHg

Toxicity:

LD50 intraperitoneal in mouse: 400mg/kg

Henrys Law Constant:

3.46e-05 atm-m3/mole

Air and Water Reactions:

Highly flammable. Soluble in water.

Reactive Group:

Amines, Phosphines, and Pyridines

Reactivity Alerts:

Highly Flammable

Reactivity Profile:

1-METHYLPIPERIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

See More N-Methylpiperidine Properties 

Hazard Identification

Classification of the substance or mixture

Flammable liquids, Category 2

Acute toxicity - Category 4, Oral

Acute toxicity - Category 4, Dermal

Skin corrosion, Sub-category 1B

Serious eye damage, Category 1

Acute toxicity - Category 3, Inhalation

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H225 Highly flammable liquid and vapour H302 Harmful if swallowed H312 Harmful in contact with skin H314 Causes severe skin burns and eye damage H331 Toxic if inhaled H412 Harmful to aquatic life with long lasting effects
Prevention	P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment.
Response	P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P317 Get medical help. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage	P403+P235 Store in a well-ventilated place. Keep cool. P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More N-Methylpiperidine Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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