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4-Chlorotoluene106-43-4

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CAS No.:

106-43-4

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

上海

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-07-17

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Detail

4-Chlorotoluene Basic information

Product Name:	4-Chlorotoluene
Synonyms:	1-chloro-4-methyl-benzen;1-Methyl-4-chlorobenzene;1-CHLORO-4-METHYLBENZENE;4-CHLOROTOLUENE;4-Chlorotoluene p-Chlorotoluene;4-CHLORO-1-METHYLBENZENE;4-Chlortoluol;4-Methylphenylchloride
CAS:	106-43-4
MF:	C7H7Cl
MW:	126.58
EINECS:	203-397-0
Product Categories:	Pyridines;Analytical Chemistry;Alphabetic;C;alkyl chloride;Pesticides intermediate;Standard Solution of Volatile Organic Compounds for Water & Soil Analysis;Standard Solutions (VOC);CH;Aryl;C7;Halogenated Hydrocarbons;Alpha Sort;Pesticides&Metabolites;CAlphabetic;Volatiles/ Semivolatiles;bc0001;A
Mol File:	106-43-4.mol

4-Chlorotoluene Chemical Properties

Melting point	6-8 °C(lit.)
Boiling point	162 °C(lit.)
density	1.07 g/mL at 25 °C(lit.)
vapor density	4.38 (vs air)
vapor pressure	10 mm Hg ( 45 °C)
refractive index	n20/D 1.52(lit.)
Fp	121 °F
storage temp.	2-8°C
solubility	0.040g/l
form	Liquid
color	Clear
PH	7.4 (H2O)(saturated aqueous solution)
explosive limit	0.7-12.2%(V)
Water Solubility	<0.1 g/100 mL at 20 ºC
Merck	14,2171
BRN	1903635
Henry's Law Constant	2.7×10^-3 mol/(m³Pa) at 25℃, Brockbank (2013)
Dielectric constant	6.0800000000000001
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.
InChI	1S/C7H7Cl/c1-6-2-4-7(8)5-3-6/h2-5H,1H3
InChIKey	NPDACUSDTOMAMK-UHFFFAOYSA-N
SMILES	Cc1ccc(Cl)cc1
LogP	3.33 at 20℃
CAS DataBase Reference	106-43-4(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 1-chloro-4-methyl-(106-43-4)
EPA Substance Registry System	p-Chlorotoluene (106-43-4)

Safety Information

Hazard Codes	Xn,N,T,F
Risk Statements	20-51/53-39/23/24/25-23/24/25-11-10-43
Safety Statements	24/25-61-45-36/37-16-7
RIDADR	UN 2238 3/PG 3
WGK Germany	2
RTECS	XS9010000
Hazard Note	Harmful
TSCA	TSCA listed
HazardClass	3
PackingGroup	III
HS Code	29036990
HS Code	29337900
Storage Class	3 - Flammable liquids
Hazard Classifications	Acute Tox. 4 Inhalation Aquatic Chronic 2 Flam. Liq. 3 Skin Sens. 1
Hazardous Substances Data	106-43-4(Hazardous Substances Data)

MSDS Information

Provider	Language
4-Chlorotoluene	English
SigmaAldrich	English
ACROS	English
ALFA	English

4-Chlorotoluene Usage And Synthesis

Chemical Properties	Colorless oily liquid. Slightly soluble in water. Soluble in ethanol, ether, acetone, benzene and chloroform.
Uses	4-Chlorotoluene is used in a variety of organic synthesis, such as acting as coupling precursors for palladium-catalyzed acylation of acetanilides. It is also used for the preparation model gas of 4-chlorotoulene by passing synthesized air into liquid 4-chlorotoulene.
Preparation	4-Chlorotoluene is obtained from p-toluidine by diazotization and substitution. Add p-toluidine and hydrochloric acid to the reaction pot and stir and heat until dissolved at 60℃, then cool to below 15℃ and add sodium nitrite solution dropwise. After reaching the end point, continue to stir for 0.5h. Add cuprous chloride hydrochloric acid solution and stir at room temperature for 3h. Then raise the temperature to 60℃ and keep for 0.5h, cool to room temperature and leave to stratify, discard the acid water layer, wash with water to neutral, filter and get p-chlorotoluene.
Definition	ChEBI: 4-Chlorotoluene is a member of monochlorobenzenes. It is an intermediate for the manufacture of Fenvalerate, Paclobutrazol, Uniconazole, Trifluralin,Thiobencarb, Daimuron and other pesticides.
Application	4-chlorotoluene is used as a solvent and intermediate for dyes and other organic chemicals. It is used mainly to produce p-chlorobenzotrichloride, from whichis obtained p-chlorobenzotrifluoride, an important precursor of herbicides (e.g., trifluralin:α,α,α,-trifluoro-2,6-dinitro-N,Ndipropyl-p-toluidine). Other side-chain-chlorinated products or their derivatives are 4- chlorobenzyl chloride (for pharmaceuticals, rice herbicides, and pyrethrin insecticides), 4- chlorobenzaldehyde (for dyes and pharmaceuticals), 4-chlorobenzoyl chloride (for pharmaceuticals and peroxides), and 4-chlorobenzoic acid (for dyes). 4-Chlorotoluene is also a starting material in the synthesis of 2,4- and 3,4-dichlorotoluene and of 4-chlorobenzonitrile. [ChemicalBook]
General Description	The reaction of 4-chlorotouleneand phenylboronic acid with Pd(OAc)2/L2HX as the catalyst is the model reaction for determining the efficiencies of bisimidazolylidene (L) ligand precursors.
Hazard	Avoid inhalation; strong irritant.
Flammability and Explosibility	Flammable
Safety Profile	Moderately toxic by ingestion. Mdly toxic by inhalation. Flammable when exposed to heat or flame. When heated to decomposition it emits toxic fumes of Cl-. See also TOLYL CHLORIDE and CHLORINATED HYDROCARBONS, AROMATIC.
Purification Methods	Dry it with BaO, fractionally distil it, then fractionally crystallise it by partial freezing. [Beilstein 5 IV 806.]

4-Chlorotoluene Preparation Products And Raw materials

Raw materials

Toluene-->Chlorine-->Copper(I) chloride-->Ferric chloride-->Copper(II) sulfate-->Sodium metabisulfite-->p-Toluidine-->2-Chlorotoluene

Preparation Products

4-Chlorobenzaldehyde-->Fomesafen-->4-Chlorobenzyl chloride-->Cyfluthrin-->2,4-Dichlorotoluene-->2-Methoxy-5-methylaniline-->4-Chlorobenzyl cyanide-->4-Chlorobenzotrifluoride-->4-Fluorobenzaldehyde-->1-[2-(4-CHLOROPHENYL)-1-(1-HYDROXY-1-PHENYLETHYL)ETHYL]-1,2,4-TRIAZOLE-->3,4-Dichlorobenzotrifluoride-->brofenvalerate-->2-(4-Chlorophenyl)-3-methylbutyric acid-->4-Chlorobenzoic acid-->2-Chlorobenzotrichloride-->5-chloro-2-methylbenzenediazonium-->4-Fluoro-3-phenoxybenzaldehyde-->4-Chlorobenzotrichloride-->2,4-Dichlorobenzotrifluoride-->FLUORODIFEN-->4-chloro-1-(dichloromethyl)benzene

Shop 3-Chloro-1-propene107-05-1-Detailed Image 2

Basic Info

Product Name:

4-Chlorotoluene

Other Name:

Benzene,1-chloro-4-methyl-;Toluene,p-chloro-;1-Chloro-4-methylbenzene;4-Chloro-1-methylbenzene;p-Chlorotoluene;p-Tolyl chloride;4-Chlorotoluene;para-Chlorotoluene;p-Chloromethylbenzene;p-Methylchlorobenzene;1-Methyl-4-chlorobenzene;4-Methylphenyl chloride;4-Tolyl chloride;4-Methylchlorobenzene;NSC 404114;4-Methyl-1-chlorobenzene

CAS No.:

106-43-4

Molecular Formula:

C7H7Cl

InChIKeys:

InChIKey=NPDACUSDTOMAMK-UHFFFAOYSA-N

Molecular Weight:

126.58

Exact Mass:

126.58

BRN:

1903635

EC Number:

203-397-0

UNII:

Q8R236H42N

ICSC Number:

1386

NSC Number:

404114

UN Number:

2238

DSSTox ID:

DTXSID8024814

Color/Form:

Colorless liquid

HScode:

29036990

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

XLogP3:

3.33

Appearance:

Clear Liquid

Density:

1.0697 g/cm³ @ Temp: 20 °C

Melting Point:

7.5 °C

Boiling Point:

162.4 °C

Flash Point:

121 °F

Refractive Index:

n 20/D 1.52(lit.)

Water Solubility:

H2O: <0.1 g/100 mL at 20 ºC

Storage Conditions:

0-6°C

Vapor Pressure:

10 mm Hg ( 45 °C)

Vapor Density:

4.38 (vs air)

Toxicity:

Oral-Rat LD50: 2100 mg/kg; Oral-Mouse LD50: 1900 mg/kg

Flammability characteristics:

Open flame, heat, oxidants are combustible; burning emits toxic chloride fumes

Explosive limit:

0.7-12.2%(V)

Experimental Properties:

Freezing point 7.20 °C @ 99.7 mole-% purity|Congealing point: 6.8 °C; lb/gal 8.85|Oxygen indexes (Minimum percentage of oxygen in an oxygen-nitrogen atm required to sustain combustion after ignition) for the chlorotoluene isomers are ... para 19.1. /Flame retardants/|At moderate temp and pressures the monochlorotoluenes are stable to the action of steam, alkalies, amines, and hydrochloric and phosphoric acids. Reactions can be divided into three classes: reactions of the aromatic ring; reactions of the methyl group; and reactions involving the chlorine substituent.|For more Other Experimental Properties (Complete) data for 4-CHLOROTOLUENE (9 total), please visit the HSDB record page.

Autoignition Temperature:

595 °C

Heat of Combustion:

-3754 kJ/mol @ 18.8 °C

Heat of Vaporization:

42.475 kJ/mol

Critical Temperature & Pressure:

Critical temperature = 385.7 °C

See More 4-Chlorotoluene Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Inhalation

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H332 Harmful if inhaled H411 Toxic to aquatic life with long lasting effects
Prevention	P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment.
Response	P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P317 Get medical help. P391 Collect spillage.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames, NO sparks and NO smoking. Above 49Â°C use a closed system, ventilation and explosion-proof electrical equipment. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Fireproof. Separated from strong oxidants.

See More 4-Chlorotoluene Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	p-CHLOROTOLUENE	400 KG	Apr 30, 2024

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