4-Chlorotoluene Safety Data Sheets
SAFETY DATA SHEETS
According to the UN GHS revision 8
SECTION 1: Identification
1.1 GHS Product identifier
| Product name | 4-chlorotoluene |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | 4-methyl-chlorobenzene; 1-chloro-4-methylbenzeene; p-tolyl chloride |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | Industrial and scientific research uses. |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | Echemi.com |
|---|---|
| Address | Echemi.com |
| Telephone | Echemi.com |
1.5 Emergency phone number
| Emergency phone number | Echemi.com |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Category 4, Inhalation
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |   |
|---|---|
| Signal word | Warning |
| Hazard statement(s) | H332 Harmful if inhaled H411 Toxic to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. |
| Response | P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P317 Get medical help. P391 Collect spillage. |
| Storage | none |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 4-chlorotoluene | 4-chlorotoluene | 106-43-4 | 203-397-0 | 100% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air, rest.
Following skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap.
Following eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Following ingestion
Do NOT induce vomiting. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed
no data available
4.3 Indication of immediate medical attention and special treatment needed, if necessary
no data available
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. Chlorotoluenes
5.2 Specific hazards arising from the chemical
Flammable. Gives off irritating or toxic fumes (or gases) in a fire. Above 49°C explosive vapour/air mixtures may be formed.
5.3 Special protective actions for fire-fighters
Use powder, AFFF, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.
6.2 Environmental precautions
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.
6.3 Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
NO open flames, NO sparks and NO smoking. Above 49°C use a closed system, ventilation and explosion-proof electrical equipment. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Fireproof. Separated from strong oxidants.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
| Component | 4-chlorotoluene | |||
|---|---|---|---|---|
| CAS No. | 106-43-4 | |||
| Limit value - Eight hours | Limit value - Short term | |||
| ppm | mg/m3 | ppm | mg/m3 | |
| Finland | 50 | 260 | 75 (1) | 390 (1) |
| Remarks | ||||
| Finland | (1) 15 minutes average value | |||
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear safety spectacles.
Skin protection
Protective gloves. Protective clothing.
Respiratory protection
Use ventilation, local exhaust or breathing protection.
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | Liquid. |
|---|---|
| Colour | Colourless. |
| Odour | no data available |
| Melting point/freezing point | 7.5 °C. |
| Boiling point or initial boiling point and boiling range | 162 °C. Atm. press.:1 013 hPa. |
| Flammability | Flammable. Gives off irritating or toxic fumes (or gases) in a fire. |
| Lower and upper explosion limit/flammability limit | no data available |
| Flash point | 49 °C. |
| Auto-ignition temperature | 570 °C. |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | dynamic viscosity (in mPa s) = 0.892. Temperature:20°C. |
| Solubility | Insoluble in water |
| Partition coefficient n-octanol/water | log Pow = 3.33. |
| Vapour pressure | 3.1 hPa. Temperature:20 °C. |
| Density and/or relative density | 1.07. Temperature:20 °C. |
| Relative vapour density | 4.38 (vs air) |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
On combustion, forms toxic gases including carbon monoxide, hydrogen chloride and possibly phosgene. Reacts with strong oxidants.
10.2 Chemical stability
no data available
10.3 Possibility of hazardous reactions
Slight, when exposed to heat or flame.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Acids, alkalis, oxidizers, reducing materials, water.
10.6 Hazardous decomposition products
no data available
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat (male) - ca. 2 273 mg/kg bw.
- Inhalation: LC50 - rat (male) - ca. 21.5 mg/L air.
- Dermal: LD50 - rat (female) - > 5 000 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis.
STOT-repeated exposure
The substance defats the skin, which may cause dryness or cracking.
Aspiration hazard
no data available
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: LC50 - Poecilia reticulata - 5.92 mg/L - 14 d.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Ceriodaphnia dubia - 1.7 mg/L - 48 h.
- Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - 6.1 mg/L - 72 h.
- Toxicity to microorganisms: EC10 - Pseudomonas putida - > 25 mg/L - 18 h.
12.2 Persistence and degradability
In the Japanese MITI test, using an initial concn of 100 ppm 4-chlorotoluene, <30% of the theoretical BOD was reached in 14 days using an activated sludge inoculum(1,2). In the modified MITI test, using an initial concentration of 100 ppm 4-chlorotoluene, 0% of the theoretical BOD was reached in 14 days(3). A microbial blend of 10 different bacteria and 2 fungi was used to degrade 4-chlorotoluene at a concentration of 200 mg/l; complete biodegradation occurred in 3 days(4). Using the cultivation method, 4-chlorotoluene at 20 mg/l was 44% and 64% biodegraded in three days using a river water and a seawater inoculum, respectively(5). An isolated strain of Pseudomonas putida 39/D oxidized 4-chlorotoluene to (+)-cis-4-chloro-2,3-dihydroxy-1-methylcyclohexa-4,6-diene (6). 4-Chlorotoluene is metabolized via cis-dihydrodiol to its respective catechol which is resistant to further degradation(7).
12.3 Bioaccumulative potential
Carp exposed to 4-chlorotoluene at 0.03 and 0.3 mg/L had measured BCF values of 14-101.6 and 21.9-76.5, respectively(1). An estimated BCF value of 200 was calculated for 4-chlorotoluene(SRC), using a measured log Kow of 3.33(2) and a recommended regression-derived equation(3). According to a recommended classification scheme(4), these BCF values suggest that some bioconcentration in aquatic organisms will occur(SRC).
12.4 Mobility in soil
The Koc of 4-chlorotoluene is estimated as approximately 340(SRC), using an experimental water solubility of 106 mg/l at 20 deg C(1,SRC) and a regression-derived equation(2,SRC). According to a recommended classification scheme(3), this estimated Koc value suggests that 4-chlorotoluene will have moderate mobility in soil(SRC).
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: UN2238 (For reference only, please check.) | IMDG: UN2238 (For reference only, please check.) | IATA: UN2238 (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: CHLOROTOLUENES (For reference only, please check.) | IMDG: CHLOROTOLUENES (For reference only, please check.) | IATA: CHLOROTOLUENES (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: 3 (For reference only, please check.) | IMDG: 3 (For reference only, please check.) | IATA: 3 (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: III (For reference only, please check.) | IMDG: III (For reference only, please check.) | IATA: III (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: Yes | IMDG: Yes | IATA: Yes |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| 4-chlorotoluene | 4-chlorotoluene | 106-43-4 | 203-397-0 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Korea Existing Chemicals List (KECL) | Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
|---|---|
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Insufficient data are available on the effect of this substance on human health, therefore utmost care must be taken.
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
4-Chlorotoluene is included in Hydrocarbons and Derivatives category. See more 4-Chlorotoluene price and marketing trends
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