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resibufagin

Unit Price:

$30000-35000/G EXW

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CAS No.:

20987-24-0

Grade:

Industrial Grade

Content:

98%

Port:

xi'an

Packaging:

5mg

Price valid (until):

2026-07-23

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Description
Resibufagin (commonly known in pharmacology as resibufogenin or bufogenin) is a bioactive bufadienolide steroid synthesized in the skin venom glands of certain Asian toads, primarily Bufo gargarizans. It is one of the premier active marker compounds found in the traditional Chinese medicine Chansu (Toad Venom).

Its primary function is acting as a specific inhibitor of the Na+/K+-ATPase pump, allowing it to modulate intracellular ion concentrations and drive diverse therapeutic effects—primarily in oncology, cardiology, and respiratory medicine.

Primary Pharmacological and Biological Functions

Antitumor and Chemotherapeutic Activity: Resibufogenin has gained widespread attention for its potent anti-cancer properties across various malignancies (such as prostate, gastric, colorectal, and lung cancers). It triggers programed cell death (apoptosis) and halts cellular proliferation by generating reactive oxygen species (ROS) and dismantling key survival networks like the PI3K/Akt and MAPK signaling pathways.

Cardiotonic Activity: Due to its structural similarity to cardiac glycosides like digoxin, it binds to and blocks the sodium-potassium pump on heart muscle cells. This inhibition elevates intracellular calcium levels, increasing cardiac output and heart muscle contraction strength to aid in heart failure management.

Central Respiratory Stimulation: It acts as a stimulant for the central nervous system, particularly targeting the respiratory center to stabilize and improve breathing functions during acute respiratory depression.

Potent Anti-Inflammatory Effects: Research proves it acts as an anti-inflammatory agent by blocking the NF-κB and AP-1 signaling pathways. This blocks the phosphorylation of IκBα, suppressing the release of pro-inflammatory cytokines like TNF-α, IL-6, and iNOS.

Anesthetic and Pain Relief: It exhibits strong local anesthetic activities and acts as an analgesic to reduce pain and swelling when formulated into complex traditional remedies.
Basic Info

Product Name:
14,15β-Epoxy-3β-hydroxy-19-oxo-5β,14β-bufa-20,22-dienolide

CAS No.:
20987-24-0

Categories:
Skin Conditioning
Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

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resibufagin

Product Description

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