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Cleomiscosin A

COA

Unit Price:

$30000-35000/G EXW

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CAS No.:

76948-72-6

Grade:

Industrial Grade

Content:

98%

Port:

xi'an

Packaging:

5mg

Price valid (until):

2026-07-22

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
Seller Information

Description

Cleomiscosin A is a naturally occurring coumarinolignan—a unique class of secondary plant metabolites where a phenylpropanoid unit is fused with a coumarin moiety via a dioxane bridge. It was first isolated from the seeds of Cleome viscosa (wild mustard), a plant heavily utilized in traditional Ayurvedic medicine.

Pharmacologically, Cleomiscosin A functions as a potent anti-inflammatory agent, hepatoprotective shield, antioxidant, and anti-diabetic modulator.

1. Significant Anti-Inflammatory Effects

Cleomiscosin A serves as a strong modulator of the body's inflammatory response, primarily by targeting overactive immune pathways:

Suppression of Pro-inflammatory Mediators: It suppresses the production of key nitric oxide (NO) radicals and reduces pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β in activated macrophages.
Upregulation of Anti-inflammatory Pathways: It helps restore immune balance by simultaneously boosting the expression of anti-inflammatory mediators.
Target Pathway Disruption: Studies indicate it interferes with core signaling pathways like the NF-κB and MAPK pathways, which prevent downstream gene expression of inflammatory markers like COX-2 and iNOS.
2. Hepatoprotection (Liver Protection)

One of its most highly documented traditional and modern functions is safeguarding liver cells. It acts as a protective shield against chemical- and drug-induced liver injuries (hepatotoxicity), maintaining structural cell integrity and lowering toxic liver enzyme leakage.

3. Antioxidant Activity & Vascular Health

Cleomiscosin A aids the body's natural defense against oxidative stress:
- Radical Scavenging: It exhibits direct free radical scavenging capacity, particularly against hydroxyl and peroxyl (HOO•) radicals.
- Cholesterol Protection: It protects Low-Density Lipoprotein (LDL) from undergoing copper-ion-mediated oxidation.
- Protein Defense: It preserves apolipoprotein B-100 (apoB-100) from fragmentation caused by systemic oxidative damage.

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Basic Info

Product Name:

Cleomiscosin A

Other Name:

9H-Pyrano[2,3-f]-1,4-benzodioxin-9-one,2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-5-methoxy-,(2R,3R)-rel-;9H-Pyrano[2,3-f]-1,4-benzodioxin-9-one,2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-5-methoxy-,trans-(±)-;rel-(2R,3R)-2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-5-methoxy-9H-pyrano[2,3-f]-1,4-benzodioxin-9-one;Cleomiscosin A;NSC 346197;121587-15-3;943537-82-4

CAS No.:

76948-72-6

Molecular Formula:

C20H18O8

InChIKeys:

InChIKey=OCBGWPJNUZMLCA-OLKMYRHANA-N

Molecular Weight:

386.35212

Exact Mass:

386.35

Categories:

Lignans

Characteristics

PSA:

104

XLogP3:

1.44

Density:

1.4±0.1 g/cm3

Melting Point:

245-247 °C

Boiling Point:

632.7±55.0 °C at 760 mmHg

Flash Point:

228.5±25.0 °C

Refractive Index:

1.618

See More Cleomiscosin A Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Cleomiscosin A Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

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Cleomiscosin A

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

More Choices Find All Products for Sale 

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