Dextrose Anhydrous: The Pure, Water-Free Form of D-Glucose

CAS Registry Number: 50-99-7

Overview

Dextrose Anhydrous is the crystalline, water-free form of D-glucose, also known simply as anhydrous glucose. Its chemical formula is C₆H₁₂O₆, with a molecular weight of 180.16 g/mol . The term "anhydrous" signifies that this form contains no water of crystallization, in contrast to glucose monohydrate (CAS 5996-10-1), which includes one water molecule per glucose molecule . It is a white, odorless, crystalline powder with a sweet taste that is less sweet than cane sugar .

Basic Information

• Molecular Formula: C₆H₁₂O₆

• Molecular Weight: 180.16 g/mol 

• CAS Number: 50-99-7 

• EINECS Number: 200-075-1 

• Synonyms: D-(+)-Glucose, Dextrose, Anhydrous Dextrose, D-Glucose Anhydrous, Corn Sugar 

Physical and Chemical Properties

• Appearance: White crystalline powder 

• Melting Point: 146°C to 152°C (anhydrous form) 

• Density: Approximately 1.54 g/cm³ at 20°C 

• Solubility: Freely soluble in water (approximately 470 g/L at 25°C), sparingly soluble in alcohol, insoluble in ether and acetone 

• Specific Optical Rotation: +52.5° to +53.3° 

• pH: Approximately 5.9 in aqueous solution 

• Vapor Pressure: Negligible 

• 
  

Major Applications

Pharmaceutical Industry

• Serves as a bulk pharmaceutical chemical and excipient for stabilizing lyophilized proteins in injectable biopharmaceutical drugs 

• Used as a wet granulation diluent and binder in tablet formulations

• Component in oral rehydration solutions and nutritional preparations

• Raw material for intravenous glucose injections

Biotechnology and Cell Culture

• Acts as a reliable source of carbon and energy for cell cultures 

• Used as a substrate in molecular biology studies and fermentation processes

• DNase-, RNase-, and Protease-Free grades available for molecular biology applications 

Food Industry

• Widely used as a sweetener in candies, ice cream, confectioneries, chocolates, biscuits, pastries, and beverages 

• Acts as a filler for oral dosage forms 

• Referenced in the U.S. Code of Federal Regulations under 21 CFR § 168.110, where it is defined as purified and crystallized D-glucose 

Other Applications

• Reducing agent in chemical processes 

• Raw material for the production of sorbitol via hydrogenation