Glucose Safety Data Sheets
SAFETY DATA SHEETS
According to the UN GHS revision 8
SECTION 1: Identification
1.1 GHS Product identifier
| Product name | Glucose |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | D-(+)-Glucose;(2R,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal;D-(+)-Dextrose |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | Processing Aids and Additives |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | Echemi.com |
|---|---|
| Address | Echemi.com |
| Telephone | Echemi.com |
1.5 Emergency phone number
| Emergency phone number | Echemi.com |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Not classified.
2.2 GHS label elements, including precautionary statements
| Pictogram(s) | No symbol. |
|---|---|
| Signal word | No signal word |
| Hazard statement(s) | none |
| Precautionary statement(s) | |
| Prevention | none |
| Response | none |
| Storage | none |
| Disposal | none |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| Glucose | Glucose | 50-99-7 | 200-075-1 | 100% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air, rest.
Following skin contact
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Following eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Following ingestion
Rinse mouth.
4.2 Most important symptoms/effects, acute and delayed
No toxicity (USCG, 1999)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Pancreatic beta cells are highly sensitive to oxidative stress, which might play an important role in beta cell death in diabetes. The protective effect of 6,6'-bieckol, a phlorotannin polyphenol compound purified from Ecklonia cava, against high glucose-induced glucotoxicity was investigated in rat insulinoma cells. High glucose (30 mM) treatment induced the death of rat insulinoma cells, but treatment with 10 or 50 ug/mL 6,6'-bieckol significantly inhibited the high glucose-induced glucotoxicity. Furthermore, treatment with 6,6'-bieckol dose-dependently reduced the level of thiobarbituric acid reactive substances, generation of intracellular reactive oxygen species, and the level of nitric oxide, all of which were increased by high glucose concentration. In addition, 6,6'-bieckol protected rat insulinoma cells from apoptosis under high-glucose conditions. These effects were associated with increased expression of the anti-apoptotic protein Bcl-2 and reduced expression of the pro-apoptotic protein Bax. These findings indicate that 6,6'-bieckol could be used as a potential nutraceutical agent offering protection against the glucotoxicity caused by hyperglycemia-induced oxidative stress associated with diabetes.
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Specific hazards arising from the chemical
Combustible. Finely dispersed particles form explosive mixtures in air.
5.3 Special protective actions for fire-fighters
Use water spray, powder, foam, carbon dioxide.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Sweep spilled substance into covered containers. Wash away remainder with plenty of water.
6.2 Environmental precautions
Sweep spilled substance into covered containers. Wash away remainder with plenty of water.
6.3 Methods and materials for containment and cleaning up
ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Avoid dust formation. Avoid breathing vapors, mist or gas; Environmental precautions: No special environmental precautions required; Methods and materials for containment and cleaning up: Sweep up and shovel. Keep in suitable, closed containers for disposal.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Separated from strong oxidants. Well closed.Keep container tightly closed in a dry and well-ventilated place. Hygroscopic. Keep in a dry place.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
no data available
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear safety goggles.
Skin protection
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Use ventilation (not if powder).
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | Watery odorless colorless liquid. Denser than water and soluble in water. Hence sinks in and mixes with water. (USCG, 1999) |
|---|---|
| Colour | Colorless crystals or white granular powder |
| Odour | Odorless |
| Melting point/freezing point | 9°C(lit.) |
| Boiling point or initial boiling point and boiling range | 73°C/25mmHg(lit.) |
| Flammability | Combustible. |
| Lower and upper explosion limit/flammability limit | no data available |
| Flash point | 40°C(lit.) |
| Auto-ignition temperature | Not flammable (USCG, 1999) |
| Decomposition temperature | no data available |
| pH | pH of 0.5 molar aqueous solution = 5.9 /alpha-glucose/ |
| Kinematic viscosity | no data available |
| Solubility | In water: Soluble |
| Partition coefficient n-octanol/water | -3.3 |
| Vapour pressure | 8.0X10-14 mm Hg at 25 deg C /extrapolated from a higher solid-phase temperature range/ |
| Density and/or relative density | 1.544g/cm3 |
| Relative vapour density | no data available |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
Reacts violently with strong oxidants.
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
Dust explosion possible if in powder or granular form, mixed with air.A weak reducing agent.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Incompatible materials: Strong oxidizing agents
10.6 Hazardous decomposition products
When heated to decomposition it emits acrid smoke and irritating fumes.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 25,800 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: D(+)-Glucose, present at 1000 mg/L, reached >90% of its theoretical BOD in 2 days using a non-adapted activated sludge inoculum at 1 g/L (dry matter) in a Zahn-Wellens static test(1). The biodegradation half-life of D(+)-glucose in aerobic aquifer material (not heavily polluted), including Ontario loam and sand, South Carolina sand and Holland sand, is reported to range from 0.6-1.1 days(2). Using an electrolytic respirometry method with a 100 mg/L compound concentration and an activated sludge inoculum, D(+)-glucose was easily biodegraded with a 46-56% theoretical BOD in 100-110 hours(3). Using standard and seawater dilution methods, the 5-day BOD of D(+)-glucose was determined as 74.8 and 75.2% respectively(4). D(+)-Glucose was readily biodegradable in batch tests using adapted activated sludge with a biodegradation rate of 180.0 mg COD/g-hour(5). Biodegradation of D(+)-glucose in various samples of aquifer, saturated zone, and surface soils was found to occur rapidly with somewhat slower rates in till soil samples(6); based on measured rate constants(6), the biodegradation half-life ranged from 0.25 to 19 days.
12.3 Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for D(+)-glucose(SRC), using a log Kow of -3.00(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc of D(+)-glucose can be estimated to be 10(SRC). According to a classification scheme(2), this estimated Koc value suggests that D(+)-glucose is expected to have very high mobility in soil.
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: No | IMDG: No | IATA: No |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| Glucose | Glucose | 50-99-7 | 200-075-1 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Not Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Korea Existing Chemicals List (KECL) | Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
|---|---|
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
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