1. Ultra-High Purity
Each batch is synthesized and purified to >99% purity (HPLC), ensuring reliable and reproducible results in sensitive experiments.
2.Accurate Dosing & Consistency
Our peptides are precisely weighed and vacuum-sealed under sterile conditions. Batch-to-batch consistency is rigorously maintained.
3.Endotoxin-Free & Sterile Processing
Manufactured in a cleanroom environment, our peptides are free from endotoxins, microbial contamination, and other impurities that could interfere with cell-based or in vivo studies.
Retatrutide (LY3437943) acetate is a triple agonist peptide for the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R).
Retatrutide acetate inhibits human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643, and 0.775 nM, respectively. It exhibits activity on mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191, and 0.794 nM, respectively.
In vivo, Retatrutide (LY3437943) acetate engages with GCGR and enhances glucose tolerance in an ipGTT by acting through GIP or GLP-1 receptors. Activation via the glucagon receptor by Retatrutide acetate leads to significant weight reduction and increased energy expenditure. Retatrutide acetate can be utilized in research related to obesity.
Retatrutide, LY3437943
CAS#: 2381089-83-2
Molecular Formula: C221H342N46O68
Molecular Weight: 4731.33
Sequence: H-Tyr-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-α-Me-Leu-Leu-Asp-Lys-{diacid-C20-gamma-Glu-(AEEA)-Lys}-Ala-Gln-Aib-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
Appearance: White Powder
Purity (HPLC): ≥99.0%
Single Impurity (HPLC): ≤1.0%
Sodium Content (HPLC): 5.0%-12.0%
Moisture Content (Karl Fischer): ≤10.0%
Peptide Content: ≥80.0%
Storage: Store at 2-8 degrees Celsius in a dry and cool place.
Packaging: 1g-1kg, plastic bottle
Intended Use: For scientific research purposes
Function
1.Treatment of depression and anxiety disorders: Retatrutide has been shown to have antidepressant and anxiolytic effects in preclinical studies, suggesting that it could be a promising treatment option for individuals with these conditions.
2.Prevention of neurodegenerative diseases: Retatrutide has neuroprotective properties that may be useful in preventing or slowing the progression of neurodegenerative diseases such as Alzheimer's and Parkinson's.
3.Enhancement of cognitive function: Retatrutide has been shown to improve learning and memory in animal studies, suggesting that it could have potential as a cognitive enhancer in humans.
4.Treatment of chronic pain: Retatrutide has been shown to have analgesic effects in preclinical studies, suggesting that it could be a useful treatment option for individuals with chronic pain conditions.
5.Promotion of wound healing: Retatrutide has been shown to accelerate wound healing in animal studies, suggesting that it could have potential as a therapeutic agent for promoting wound healing in humans.
Application
1.Retatrutide is often used in the pharmaceutical industry, weight losing, etc.
2.Retatrutide is a kind of peptide product.
3.Retatrutide acetate can inhibited GCGR, GIPR and GLP-1R.
4.Retatrutide acetate is activated by glucagon receptors resulting in significant weight loss and increased energy expenditure.
5.Retatrutide acetate can be used in studies of obesity.
Product name | Retatrutide | CAS NO. | 2381089-83-2 |
Purity | 99% | Molecular weight | 4731.33 |
Appearance | White powder | Molecular Formula | C221H342N46O68 |
Specifications | Frozen | Function | Weight loss |
Storage | Storage | Function | Weight loss |