Add to WhatsApp: +85244962136 Amy
I will provide you with more comprehensive information, and I look forward to cooperating with you.
| Items | Specifications |
| Product Name | EPO |
| CAS | 142443-98-9 |
| Purity | >99% |
| Appearance | Powder |
| Specification | 3000iu*10vials |
-
In medicine, EPO stands for Erythropoietin. It is a glycoprotein hormone primarily secreted by the kidneys. Its core function is to stimulate the proliferation of hematopoietic stem cells in the bone marrow and their differentiation into mature red blood cells, thereby maintaining the oxygen-carrying capacity of the blood. When the body is in a state of hypoxia (oxygen deficiency) or anemia, its secretion increases.
Physiological Origin and Mechanism of Action
- Site of Production: In adults, it is primarily synthesized by the interstitial cells surrounding the cortical tubules in the kidneys. During the fetal stage, it is mainly produced by the liver.
- Target of Action: EPO binds to specific receptors on the surface of erythroid progenitor cells in the bone marrow, promoting hemoglobin synthesis and red blood cell maturation.
- Regulatory Mechanism: Its secretion is regulated by a feedback mechanism based on blood oxygen saturation. Secretion increases during hypoxia and decreases when the red blood cell count rises.
Primary Functions of EPO
1. Promoting Red Blood Cell Production (Core Hematopoietic Function)
When the body is in a state of hypoxia or anemia, the kidneys sense this and increase EPO secretion. By binding to receptors on the surface of erythroid progenitor cells in the bone marrow, EPO stimulates the survival, proliferation, and differentiation of these cells. They eventually mature into red blood cells, thereby enhancing the oxygen-carrying capacity of the blood.
2. Clinical Treatment of Anemia
Based on its hematopoietic function, artificially synthesized recombinant human erythropoietin (rHuEPO) is widely used in clinical settings. It is primarily used to treat anemia caused by the following conditions:
- Anemia associated with chronic renal insufficiency/renal failure (this is the most typical application).
- Anemia caused by malignant tumors or chemotherapy.
- Anemia caused by Acquired Immunodeficiency Syndrome (AIDS) itself or its treatments.
- Chronic anemia caused by rheumatic diseases, rheumatoid arthritis, and severe parasitic infections, among others.
3. Non-Hematopoietic Tissue Protection and Immunoregulation (Cutting-Edge Research)
Recent studies have revealed that the functions of EPO extend far beyond hematopoiesis. Its receptors are widely distributed in various organs, including the heart, brain, retina, and pancreas. In these tissues, EPO exhibits non-hematopoietic tissue-protective effects. Examples include protecting neurons during cerebral ischemia, promoting angiogenesis, regulating innate and adaptive immune cells, and participating in the regulation of fat and glucose metabolism.
- 1.Temperature
*For short-term storage (days to weeks), a standard refrigerator (2–8°C) is usually sufficient.
*For medium- to long-term storage (months to years), lyophilized vials should be kept in a -20°C freezer. If conditions permit, ultra-low temperature storage at -80°C can further extend the stability period.
- 2.Protection from Light and Moisture
UV and visible light can catalyze the oxidation of certain amino acid residues (especially tryptophan, tyrosine, and methionine). Vials should be stored in their original packaging or opaque containers. Additionally, moisture is the primary enemy of lyophilized powders. Absorbing moisture reintroduces water necessary for hydrolysis; therefore, reconstitution operations should be performed swiftly, and the vial must be sealed tightly.
- 3.Avoid Unnecessary Temperature Cycling
When removing vials from the freezer, the best practice is to allow the sealed vial to reach room temperature before opening. This prevents condensation from forming on the inner walls of the vial, which would otherwise introduce moisture and promote degradation.
- 4.Do Not Freeze Solutions Reconstituted with Bacteriostatic Water
If reconstituted with bacteriostatic water for parenteral use (containing 0.9% benzyl alcohol as a preservative), the solution must not be frozen. Freezing can disrupt the distribution of benzyl alcohol and potentially cause phase separation. Furthermore, the formation of ice crystals exerts mechanical shear stress on peptide molecules, accelerating aggregation and degradation. Solutions prepared with bacteriostatic water should only be refrigerated and used within their valid shelf life.
- 5.Storage of Solutions Reconstituted with Sterile Water
If reconstituted with preservative-free sterile water for parenteral use, the solution lacks antimicrobial protection, posing a higher risk of microbial contamination and resulting in a shorter usable lifespan under refrigeration (typically only a few days). If longer storage is required in this case, the solution can be aliquoted into small volumes and frozen in a single batch to minimize repeated freeze-thaw cycles.
- 6.Avoid Repeated Freeze-Thaw Cycles
Regardless of the solvent used, repeated freezing and thawing is one of the most destructive processes for reconstituted peptides. Each freeze-thaw cycle induces peptide aggregation and loss of bioactivity. If freezing is necessary, always aliquot the solution into single-use vials, following the principle of "thaw one aliquot, use it entirely."
- 7.Maintain Stability and Cleanliness
When refrigerating, place vials securely in the most temperature-stable area of the refrigerator (typically the middle shelf, rather than the frequently opened door racks). Always use aseptic techniques when withdrawing the solution, and avoid repeated contamination of the liquid inside the vial by the needle.
Our company is located in Zhejiang Province and is a Chinese enterprise specializing in the production of peptide products.We are not intermediaries or resellers; we are the original manufacturer. This allows us to offer you the most competitive pricing. Our motto is: to manufacture products with care and serve customers with dedication.We are dedicated to serving every visitor with heart. No matter where you come from, you will experience our premium VIP service. We guarantee that every customer receives only the finest products, backed by exceptional after-sales support, as we strive to ensure your complete satisfaction.
1.Higher quality products (>=99% purity) for most of peptides and raws., adequate stock and fast delivery competitive price.
2. Ship worldwide with safe and secure lines:
3. Special Service: Drop-shipping if need.
4. Cheapest prices in the market, unbeatable！
1. How to make an order?
Simply send us a message with the quantity you need. I will calculate the price and offer you a special discount. Once payment is confirmed, we will prioritize your order for immediate dispatch.
2. What's the lead time and shipping ways?
We will delivery to the package by UPS, FEDEX, DHL paket and YANWEN express to you after receive your payment, it would take 10-15 days.
We will also track the logistics throughout the entire process and update the logistics information for buyers in real time.
3. What's the payment methods?
We could accept pay through Alipay, USDT, BTC and TT.
4.Does the product have a test report?
Each batch of our products undergoes testing before leaving the factory, and a Certificate of Analysis (COA) report is issued.
5.Can customers customize their own labels?
Custom labeling services are available. Please contact us to discuss your specific requirements prior to placing an order.
6.What is the product's shelf life?
When unopened, our products have a shelf life of two years under both room temperature and frozen storage conditions. Therefore, you can rest assured that extended shipping times will not cause the product to expire or degrade.
United States
Denmark
Spain
