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Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0

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CAS No.:

103-80-0

Grade:

Pharmaceutical Grade

Content:

99.99%

Port:

Shanghai

Brand:

Orient

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-07-24

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China

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pharmaceutical intermediates,peptides,electronic chemicals

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As an integrated chemical foreign trade firm, we combine independent R&D, manufacturing, bespoke production and global distribution, focusing on delivering high-quality chemical supplies and comprehensive professional services to clients around the globe.

With rich experience accumulated in the chemical sector, we have built a complete industrial layout. Stable product performance, flexible custom manufacturing solutions and thoughtful customer support have won wide recognition from partners worldwide.

We own a modern, well-equipped chemical manufacturing plant equipped with intelligent automated production lines and strict quality inspection systems. Built in accordance with international standards and certified by relevant industrial authorities, our plant adopts standardized, safe and environmentally compliant production procedures. Every link from raw material procurement to finished product packaging is operated and monitored by professional teams to maintain stable and consistent product quality.

To meet diversified demands from buyers, we have a dedicated customization team composed of experienced chemical engineers. We provide comprehensive tailor-made solutions including formula adjustment, customized product specifications and exclusive packaging design. Whether you need small trial batches or large bulk orders, we maintain smooth communication throughout the customization process to match your specific requirements accurately.

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In the future, we will continuously upgrade our R&D and manufacturing capabilities, expand our global sales channels, and strive to develop into a reliable and well-established global chemical trading enterprise. We sincerely welcome customers from all over the world to send inquiries and establish win-win cooperation for shared development.

Phenylacetyl chloride Basic information

Product Name:	Phenylacetyl chloride
Synonyms:	Acetyl chloride, phenyl-;alpha-Phenylacetyl chloride;alpha-Toluyl chloride;phenylacetyl;-Toluylchloride;AKOS BBS-00003909;A-TOLUYL CHLORIDE;LABOTEST-BB LT00643802
CAS:	103-80-0
MF:	C8H7ClO
MW:	154.59
EINECS:	203-146-5
Product Categories:	Pharmaceutical Intermediates;Acid Halides;Carbonyl Compounds;Organic Building Blocks;A
Mol File:	103-80-0.mol

Phenylacetyl chloride Chemical Properties

Melting point	264-266 °C(Solv: N,N-dimethylformamide (68-12-2))
Boiling point	94-95 °C/12 mmHg (lit.)
density	1.169 g/mL at 25 °C (lit.)
refractive index	n20/D 1.5325(lit.)
Fp	217 °F
storage temp.	2-8°C
solubility	Miscible with alcohol and ether.
form	clear liquid
color	Colorless to Light yellow
Sensitive	Moisture Sensitive
BRN	742254
Stability:	Stable. Reacts with water. Incompatible with amines, most common metals, moisture, strong oxidizing agents.
InChI	1S/C8H7ClO/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2
InChIKey	VMZCDNSFRSVYKQ-UHFFFAOYSA-N
SMILES	ClC(=O)Cc1ccccc1
LogP	1.628 (est)
CAS DataBase Reference	103-80-0(CAS DataBase Reference)
NIST Chemistry Reference	Benzeneacetyl chloride(103-80-0)
EPA Substance Registry System	Benzeneacetyl chloride (103-80-0)

Safety Information

Hazard Codes	C
Risk Statements	34-37-14
Safety Statements	26-36/37/39-45-25-27
RIDADR	UN 2577
WGK Germany	3
F	21
TSCA	TSCA listed
HazardClass	8
PackingGroup	II
HS Code	29163900
Storage Class	8A - Combustible corrosive hazardous materials
Hazard Classifications	Eye Dam. 1 Met. Corr. 1 Skin Corr. 1B STOT SE 3

Phenylacetyl chloride Usage And Synthesis

Chemical Properties	colourless liquid
Uses	Phenylacetyl chloride is used in the preparation of 1,2-diphenyl-ethanone by reaction with iodobenzene using tetrabutylammonium tetrafluoroborate as a phase transfer catalyst. It is widely used in the chemical industry for manufacturing dyes and pharmaceutical products. It plays an important role in the preparation of penicillin. Further, it is used to prepare esters for flavorings.
Uses	Phenylacetyl chloride is used as a key precursor in the total synthesis of vialinin B. It is employed as a linker to prepare dendrimers and also used in the synthesis of various conjugated aromatic small molecules.
Synthesis Reference(s)	Journal of the American Chemical Society, 96, p. 6469, 1974 DOI: 10.1021/ja00827a034 Organic Syntheses, Coll. Vol. 2, p. 156, 1943
General Description	A colorless volatile liquid with a strong odor. Denser than water. Contact may severely irritate skin, eyes and mucous membranes. May be toxic by ingestion. May also be combustible.
Air & Water Reactions	Soluble in water. Fumes in air. Decomposes in water or steam to form very corrosive hydrogen chloride gas.
Reactivity Profile	Phenylacetyl chloride is incompatible with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health Hazard	TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard	Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Synthesis	First, weigh 0.136 kg (1.0 mol) of phenylacetic acid and place it in a 250 mL four-necked flask equipped with a thermometer, a tail gas pipe, a phosgene receiving tube, and a mechanical stirrer. Then add a catalyst accounting for 1%–2% of the total mass. Place the reaction flask in an oil bath and heat it to 78 °C, the melting point of phenylacetic acid. Start slow stirring after the phenylacetic acid dissolves gradually. Next, connect the phosgene receiving tube to a 500 mL PTFE bottle containing liquid phosgene. Given that phosgene has a boiling point of only 8.2 °C, it can be vaporized spontaneously at room temperature and then introduced into the reaction flask to react with the raw material at a certain temperature. After the introduction of phosgene is completed, maintain the temperature for a period of reaction. During this process, phosgene can be quantified by weighing with an analytical balance to control the ratio of raw materials. The completion of the reaction can be determined by the results of gas chromatography (GC) analysis. Subsequently, carry out vacuum distillation to remove low-boiling-point impurities. After all volatile substances are eliminated, collect the fraction at 85–90 °C under a pressure of -0.096 MPa, and the target product, phenylacetyl chloride, is thus obtained.

Phenylacetyl chloride Preparation Products And Raw materials

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 3

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 4

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 5

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 6

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 7

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 8

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 9

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 10

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 11

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 12

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 13

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 14

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 15

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 16

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 17

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 18

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 19

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 20

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 21

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 22

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 23

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 24

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 25

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 26

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 27

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 28

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 29

Shop Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0-Detailed Image 30

Certificates

Basic Info

Product Name:

Phenylacetyl chloride

Other Name:

Benzeneacetyl chloride;Acetyl chloride,phenyl-;Phenylacetyl chloride;Phenacetyl chloride;Phenylacetic acid chloride;α-Phenylacetyl chloride;Phenylacetic chloride;2-Phenylacetyl chloride;2-Phenylethanoyl chloride;2-Phenylacetic acid chloride

CAS No.:

103-80-0

Molecular Formula:

C8H7ClO

InChIKeys:

InChIKey=VMZCDNSFRSVYKQ-UHFFFAOYSA-N

Molecular Weight:

154.59

Exact Mass:

154.59

BRN:

742254

EC Number:

203-146-5

UNII:

T30899DRND

UN Number:

2577

DSSTox ID:

DTXSID6059281

HScode:

29163900

Categories:

Blood Glucose Regulators

Characteristics

PSA:

17.1

XLogP3:

2.23

Appearance:

Phenylacetyl chloride appears as a colorless volatile liquid with a strong odor. Denser than water. Contact may severely irritate skin, eyes and mucous membranes. May be toxic by ingestion. May also be combustible.

Density:

1.2±0.1 g/cm3

Melting Point:

264-266 °C @ Solvent: Dimethylformamide

Boiling Point:

170 °C

Flash Point:

217 °F

Refractive Index:

1.535

Water Solubility:

Miscible with alcohol and ether.

Storage Conditions:

2-8°C

Vapor Pressure:

0.20 mmHg

Air and Water Reactions:

Soluble in water. Fumes in air. Decomposes in water or steam to form very corrosive hydrogen chloride gas.

Reactive Group:

Acyl Halides, Sulfonyl Halides, and Chloroformates

Reactivity Alerts:

Water-Reactive

Reactivity Profile:

PHENYLACETYL CHLORIDE is incompatible with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

See More Phenylacetyl chloride Properties 

Hazard Identification

Classification of the substance or mixture

Skin corrosion, Category 1

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H314 Causes severe skin burns and eye damage H335 May cause respiratory irritation
Prevention	P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P319 Get medical help if you feel unwell.
Storage	P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Phenylacetyl chloride Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221
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Phenylacetyl chloride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 103-80-0

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