Trifluoroacetic anhydride | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | CAS 407-25-0

Trifluoroacetic anhydride Basic information
Product Name: Trifluoroacetic anhydride
Synonyms: TIFLUOROACETIC ANHYDRIDE;TRIFLUOROACETO ANHYDRIDE;Trifluoroacetic acid anhydride (TFAH);RIFLUOROACETIC ANHYDRIDE;Trifluoroacetic anhydride 10g [407-25-0];Trifluoroacetic anhy;Trifluoroacetic anhydride, min. 98%;trifluoroacetyl 2,2,2-trifluoroacetate
CAS: 407-25-0
MF: C4F6O3
MW: 210.03
EINECS: 206-982-9
Product Categories: Pharmaceutical intermediates;Acylation Reagent;Halogen compounds;Organic Fluorides;Building Blocks;top;Acylation (GC Derivatizing Reagents);Analytical Chemistry;Fluorinated Building Blocks;organofluorine compound;Carbonyl Compounds;Carboxylic Acid Anhydrides;Chemical Synthesis;Organic Building Blocks;Organics;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;GC Derivatizing Reagents;Synthetic Organic Chemistry;407-25-0;K00001
Mol File: 407-25-0.mol
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Trifluoroacetic anhydride Chemical Properties
Melting point -65 °C (lit.)
Boiling point 39.5-40 °C (lit.)
density 1.511 g/mL at 20 °C (lit.)
vapor pressure 6.28 psi ( 20 °C)
refractive index n20/D 1.3(lit.)
Fp -26 °C
storage temp. 2-8°C
solubility Miscible with benzene, dichloromethane, diethyl ether, dimethylformamide, terahydrofuran and acetonitrile.
form Liquid
pka 0.43[at 20 ℃]
color Clear
Specific Gravity 1.487
Water Solubility Hydrolysis
Sensitive Moisture Sensitive
BRN 746197
Stability: Stable, but moisture sensitive. Reacts with water to liberate hydrogen (flammable!). Incompatible with water, strong oxidizing agents.
InChI 1S/C4F6O3/c5-3(6,7)1(11)13-2(12)4(8,9)10
InChIKey QAEDZJGFFMLHHQ-UHFFFAOYSA-N
SMILES FC(F)(F)C(=O)OC(=O)C(F)(F)F
LogP 0.79 at 25℃
CAS DataBase Reference 407-25-0(CAS DataBase Reference)
NIST Chemistry Reference Acetic acid, trifluoro-, anhydride(407-25-0)
EPA Substance Registry System Acetic acid, trifluoro-, anhydride (407-25-0)

Safety Information
Hazard Codes C,T
Risk Statements 14-20-35-52/53-34-23/24/25
Safety Statements 26-36/37/39-43-45-61-9-8-28A-27
RIDADR UN 3265 8/PG 1
WGK Germany 2
RTECS AJ9800000
F 3-10
Hazard Note Corrosive/Moisture Sensitive
TSCA TSCA listed
HazardClass 8
PackingGroup I
HS Code 29159080
Storage Class 8B - Non-combustible corrosive hazardous materials
Hazard Classifications Acute Tox. 4 Inhalation
Aquatic Chronic 3
Eye Dam. 1
Skin Corr. 1A
Toxicity skn-rbt 500 mg/24H SEV 28ZPAK -,91,72
MSDS Information
Provider Language
2,2,2-Trifluoroacetic anhydride English
SigmaAldrich English
ACROS English
ALFA English

Trifluoroacetic anhydride Usage And Synthesis
Description Trifluoroacetic acid anhydride (TFAA), a perfluoroacylated acylation reagent, forms stable, volatile derivatives with alcohols, amines, and phenols.
Chemical Properties Clear, colorless liquid
Uses Used as analytical reagents, solvents, catalysts, dehydration condensing agent, protection agent of trifluoroacetylation of carboxyl and amino; used as Intermediate of fluorine fine chemicals, pharmaceutical, agrochemical.
Uses Trifluoroacetic anhydride is used for the introduction of trifluoroacetyl group in organic synthesis. It is involved in the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for gas chromatography analysis. It plays an important role as desiccant for trifluoroacetic acid. It is also used in the oxidation of aldehydes to acids, esters, amides as well as in the protection of alcohols and amines. In addition, it is used as analytical reagents, solvents and dehydration condensing agent. It serves as an intermediate of fluorine fine chemicals, pharmaceuticals and agrochemicals.
Preparation Trifluoroacetic anhydride is prepared by reaction of trifluoroacetyl chloride with an alkali metal or alkaline-earth metal salt of trifluoroacetic acid at approximately 50° C.
reaction suitability reagent type: derivatization reagent
reaction type: Acylations
reagent type: derivatization reagent
reaction type: Esterifications
Safety Profile A severe skin and eye irritant.Explosive reaction with dimethyl sulfoxide; nitric acid +1,3,5-triazine (at 36°C); nitric acid + 1,3,5-triacetylhexahydro-1,3,5-triazine (at 30°C). Incompatiblewith lithium tetrahydroaluminate. When heated todecomposit
Purification Methods Purification by distilling over KMnO4, as for the acid above, is EXTREMELY DANGEROUS due to the possiblility of EXPLOSION. It is best purified by distilling from P2O5 slowly, and collecting the fraction boiling at 39.5o. Store it in a dry atmosphere. Highly TOXIC vapour and attacks skin, work in an efficient fume hood. [Beilstein 2 IV 469.]

Trifluoroacetic anhydride Preparation Products And Raw materials
Raw materials Trifluoroacetic acid-->DICHLOROACETIC ANHYDRIDE
Preparation Products Chlorfenapyr-->2-Chloro-4-(trifluoromethyl)pyrimidine-->2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbaldehyde-->(2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanamine-->Ethyl 2-(4-hydroxypiperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate-->1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-->Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate-->1-[4-(TRIFLUOROMETHYL)PYRIMID-2-YL]PIPERAZINE-->ETHYL 5-AMINO-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE-->5-Bromo-2-hydroxymethylpyridine-->3-Nitroisonicotinic acid-->Ethyl 2-(4-(ethoxycarbonyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate-->5-Bromopyridine-2-carbaldehyde-->N10-(TRIFLUOROACETYL)PTEROIC ACID-->tert-Butyl 4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazine-1-carboxylate ,97%-->2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbonitrile-->2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINIC ACID-->(2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanol-->2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide-->3-CHLORO-5-NITROPYRIDINE-->2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-amine-->2,6-DICHLORO-4-ISOCYANATOPYRIDINE-->2-Hydroxy-4-(trifluoromethyl)pyrimidine-->2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylic acid-->Ethyl 2-(4-methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate-->2-(Bromomethyl)-6-methylpyridine-->2-BROMO-4-(TRIFLUOROMETHYL)PYRIMIDINE-->6-Aminobenzothiazole-->5-Iodo-2,4-dimethoxypyrimidine-->2-(METHYLTHIO)-4-(TRIFLUOROMETHYL)PYRIMIDINE-->2-(TRIFLUOROACETYL)THIOPHENE-->[Bis(trifluoroacetoxy)iodo]benzene-->3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-->2-CYANO-4-PYRIDINE CARBOXYLIC ACID-->Epirubicin