Trifluoroacetic anhydride
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Trifluoroacetic anhydride
structure -
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CAS No:
407-25-0
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Formula:
C4F6O3
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Chemical Name:
Trifluoroacetic anhydride
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Synonyms:
Acetic acid,2,2,2-trifluoro-,1,1′-anhydride;Acetic acid,trifluoro-,anhydride;Trifluoroacetic anhydride;Perfluoroacetic anhydride;Trifluoroacetic acid anhydride;Hexafluoroacetic anhydride;Trifluoroacetyl anhydride;Bis(trifluoroacetic) anhydride;2,2,2-Trifluoroacetic anhydride;NSC 96965;(2,2,2-Trifluoroacetyl) 2,2,2-trifluoroacetate
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CAS No:
Description
Clear, colorless liquid
Trifluoroacetic anhydride (TFAA) is the acid anhydride of trifluoroacetic acid. It is the perfluorinated derivative of acetic anhydride. Like many acid anhydrides, it may be used to introduce the corresponding trifluoroacetyl group. The corresponding acyl chloride, trifluoroacetyl chloride, is a gas, making it inconvenient to work with. Trifluoroacetic anhydride is the recommended desiccant for trifluoroacetic acid.
Liquid
Characteristics
43.37000
1.18080
Liquid
1.490 g/cm3 @ Temp: 25 °C
-65 °C
39.5 °C
-26ºC
1.269
Hydrolysis
2-8ºC
6.28 psi ( 20 °C)
skn-rbt 500 mg/24H SEV 28ZPAK -,91,72
Safety Information
I
8
UN 1760/3265
2
R14; R20; R35; R52/53
S26-S27-S28-S45-S61-S8-S9
AJ9800000
C
Stable, but moisture sensitive. Reacts with water to liberate hydrogen (flammable!). Incompatible with water, strong oxidizing agents.
P280-P305 + P351 + P338-P310
H314-H332
UN 1760/3265
Trifluoroacetic anhydride Use and Manufacturing
Used as analytical reagents, solvents, catalysts, dehydration condensing agent, protection agent of trifluoroacetylation of carboxyl and amino; used as Intermediate of fluorine fine chemicals, pharmaceutical, agrochemical.
Intermediates
All other basic organic chemical manufacturing|Acetic acid, 2,2,2-trifluoro-, 1,1'-anhydride: ACTIVE
Computed Properties
Molecular Weight:210.03
XLogP3:2.1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:2
Exact Mass:209.97516283
Monoisotopic Mass:209.97516283
Topological Polar Surface Area:43.4
Heavy Atom Count:13
Complexity:201
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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