N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)acetamide Exatecan Intermediate 6 CAS 143655-58-7 NT

Exatecan Intermediate 6 (CAS 143655-58-7), also known as N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)acetamide, is a key synthetic intermediate in the production of Exatecan (DX-8951). This compound serves as a building block in the linear synthesis of Exatecan, representing the precursor to the ABC-ring system of the final drug molecule.

Role in Exatecan Synthesis:

Exatecan is a water-soluble camptothecin analog and a non-prodrug that exhibits potent antitumor activity as a DNA topoisomerase I inhibitor (IC₅₀ = 2.2 μM, 0.975 μg/mL). It is commonly used as a cytotoxin payload in antibody-drug conjugates (ADCs) for targeted cancer therapy. This compound is one of the key intermediates in the multi-step synthesis of the API, introducing the fluorinated tetrahydronaphthalenone core structure essential for the drug's biological activity.

Key Features:

• High Purity: ≥ 98% (HPLC), meeting rigorous quality standards

• Key Intermediate: Essential for the synthesis of Exatecan API

• ADC Payload Precursor: Used in the development of antibody-drug conjugates

• Well-characterized with available analytical data (NMR, HPLC, etc.)

Applications:

• Pharmaceutical R&D: As a key intermediate in the synthesis of Exatecan API and ADC payload development

• Analytical R&D: Serves as a reference standard for quality control (QC) and analytical method development (AMV)

• Cancer Research: Used in studies involving topoisomerase I inhibition and targeted cancer therapy

Packaging: ___ (e.g.: 1g, 5g, 10g, 25kg per package, as per customer's request)

Storage: Powder: -20°C for up to 3 years; 4°C for up to 2 years. In solvent: -80°C for 6 months; -20°C for 1 month. Protect from light and moisture.

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