(S)-(+)-Abscisic acid CAS 21293-29-8 98% white to off-white crystalline powder plant hormone / plant growth regulator and biochemical research reagent

1. Product Overview

(S)-(+)-Abscisic acid, also known as (+)-Abscisic acid, S-ABA, or Dormin (CAS 21293-29-8; molecular formula C₁₅H₂₀O₄; MW 264.32), is the naturally occurring enantiomer of the key plant hormone abscisic acid (ABA). It appears as white to off-white or pale yellow crystalline powder/needles, highly sensitive to light and heat. As the principal “stress hormone” in plants, it acts as a growth inhibitor regulating seed dormancy, germination arrest, stomatal closure under drought/salt stress, and abiotic stress responses. The natural (S)-(+)-isomer is biologically active, whereas the racemate is less potent. This product is supplied at ≥98% purity (HPLC), suitable for plant physiology research, tissue culture additives, agrochemical formulation R&D, and biochemical signaling pathway studies. It is light-sensitive and stored refrigerated (−20 °C or 2–8 °C) in amber vials under inert atmosphere.

2. Key Features and Advantages

• Natural (S)-(+)-configuration with high stereospecific bioactivity; specific rotation [α]ᴰ²⁰ +400 to +430° (c = 0.2, EtOH), ensuring authentic plant hormone response in assays.

• ≥98% HPLC purity with low isomer/racemate content, ideal for quantitative plant signaling and stomatal conductance experiments.

• High solubility in ethanol, methanol, DMSO, acetone, ethyl acetate; slightly soluble in water (~3 mg/L at pH 4), enabling flexible formulation in aqueous buffer systems via bicarbonate/NaOH dissolution.

• Provided as off-white crystalline solid stable under −20 °C in amber containers; compatible with plant tissue culture media (MS medium supplementation at nM–μM levels).

• Well-characterized melting point 160–188 °C (literature 188 °C dec.), pKa ~4.87, facilitating pH-dependent extraction and analytical method development (HPLC, LC-MS).

• Available in lab-scale packs (mg–g) and bulk agro-grade (99% technical) for formulation trials.

3. Main Applications

• Plant physiology & biochemistry research: studying seed dormancy, germination inhibition, stomatal closure, drought/salt/cold stress signaling pathways in Arabidopsis, crops, and model plants.

• Plant tissue culture: added to MS medium at 0.1–10 μM to induce somatic embryogenesis, suppress premature germination, and synchronize developmental stages.

• Agrochemical R&D: as a reference standard for S-ABA-based plant growth regulator (S-abscisic acid / S-abscisin) formulations used to enhance crop stress tolerance, improve fruit coloring, and reduce pre-harvest drop.

• Analytical standard: HPLC/LC-MS reference material for quantifying endogenous ABA levels in plant extracts, sap, or leaf tissues.

• Biochemical signaling studies: investigating ABA receptors (PYR/PYL family), LANCL2 interaction, Ca²⁺ signaling, and ABA-mediated gene expression in plant and some animal cell models.

4. Technical Specifications

5. Storage and Handling

Store at −20 °C in a tightly sealed amber vial under inert atmosphere (N₂ or Ar) to prevent photodegradation and oxidation; 2–8 °C acceptable for short-term (≤1 month) if protected from light. This compound is strongly light-sensitive (UV and visible light cause cis–trans isomerization and decomposition) and heat-sensitive; avoid exposure to direct sunlight, fluorescent lamps, and temperatures >25 °C. Handle in a fume hood with minimal light exposure; use amber glass or foil-wrapped containers during weighing. Dissolve in ethanol, DMSO, or 0.1 M NaHCO₃ solution immediately before use; avoid prolonged storage in solution (prepare fresh working stocks). Use nitrile gloves, lab coat, and safety goggles. Do not inhale dust; wash hands thoroughly after handling. For disposal, collect as hazardous organic waste per local regulations (WGK Germany 3, aquatic toxicity concern).

6. Safety Overview

Classified under GHS as Warning (GHS07) or Danger for environmental (some regs GHS09). Hazard statements: H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation), H410 (Very toxic to aquatic life with long-lasting effects—UN3077 Class 9 PG III for transport). Precautionary: P261 (Avoid breathing dust), P264 (Wash after handling), P271 (Use outdoors/well-ventilated), P273 (Avoid release to environment), P280 (Protective gloves/eyewear), P305+P351+P338 (Eye rinse), P391 (Collect spillage), P501 (Dispose as hazardous waste). Not for human/veterinary therapeutic use; for research, plant tissue culture, and agrochemical formulation R&D only. TCI/major suppliers ship as UN3077 Environmentally Hazardous Substance, Solid, N.O.S. (Abscisic acid), Class 9, PG III. Consult full SDS before use; keep away from strong oxidizers, acids, and acidic chlorides.