N-Methylpiperazine 1-Methylpiperazine CAS 109-01-3 Pharma Grade 99% Intermediate for Drugs Pesticides Dyes

Product Name: N-Methylpiperazine (1-Methylpiperazine)

CAS No.: 109-01-3

Molecular Formula: C₅H₁₂N₂

Molecular Weight: 100.16

EINECS No.: 203-639-5

Synonyms: 1-Methylpiperazine, N-Methylpiperazine, Methylpiperazine, 4-Methylpiperazine, NMP

Product Introduction

N-Methylpiperazine (CAS 109-01-3) is a heterocyclic diamine belonging to the alkylated piperazines family. It is a high-purity organic intermediate in the form of colorless to light yellow clear liquid with a characteristic amine-like odor. The compound is hygroscopic and is miscible with water, ethanol, ether, and methanol in any ratio, with an aqueous solution exhibiting weak alkalinity.

With a purity of ≥99.0% by GC, N-Methylpiperazine serves as a versatile building block and intermediate in organic synthesis. Its unique chemical properties—including its basicity (pKa ~9.16), ability to form hydrogen bonds, and nucleophilic character—make it highly valuable in pharmaceutical, agrochemical, and polymer industries.

Key Applications

1. Pharmaceutical Intermediates (Primary Application)

N-Methylpiperazine serves as a critical building block for the production of numerous active pharmaceutical ingredients (APIs). It is a key intermediate in the synthesis of:

• Antibiotics: Rifampicin

• Antipsychotics: Trifluoperazine

• Anti-infectives: Ofloxacin, Clozapine

• PDE5 Inhibitors: Sildenafil

• Antihistamines: Cyclizine, Meclizine

• Sedatives/Hypnotics: Zopiclone

• Antiemetics: Trifluoperazine

2. Agrochemical Industry

Used in the production of pesticides, herbicides, and fungicides.

3. Textile Industry

Used as an additive in the processing of textile fibers.

4. Polymer and Dye Industry

Plays an essential role in the synthesis of polymers including polyurethanes and polyamides, as well as in the production of dyes and plastic additives.

5. Catalyst Preparation

Used in the preparation of catalysts for various organic reactions.

6. Analytical Chemistry

Used as a mimic template in the preparation of molecularly imprinted microspheres (MIMs) and in the generation of difunctional strong anion-exchange stationary phases.

Company Profile

Jinan Topfull Chemical Co., Ltd. is a China-based international company specializing in the export of high-quality chemical products. Committed to excellence, we strive to deliver ideal solutions to clients across diverse chemical sectors worldwide.Our extensive product portfolio includes, but is not limited to:Organic and inorganic reagents，Biological reagents，Plant extracts，Pharmaceutical intermediates，Active pharmaceutical ingredients (APIs)。Reference standards and reference substances and more

We have established long-term, stable collaborations with university laboratories and external research institutions, enabling us to offer tailored product services based on specific client requirements. Currently, we support customization services for most product categories, with flexible supply options ranging from milligram (mg) and gram (g) quantities to kilogram (kg) volumes and bulk orders. Our products are available in purities from 90% to 99.9%, ensuring comprehensive coverage to meet diverse application needs
To date, our products have been exported to dozens of countries and regions across the globe, including the United States, Australia, Canada, Mexico, and other Western developed countries, as well as European Union member states

such as France and Germany. We also serve markets in Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise from customers worldwide. L ooking ahead, we will continue to serve as a reliable bridge between China and the global market, dedicated to providing premium products and professional services to customers around the world.

At Jinan Topfull Chemical, we are committed to offering convenient, one-stop solutions that streamline procurement and support our customers' success.



FAQ
Q1: Can i get some samples?
A: Yes, we can supply the sample, but the shipping cost be paid by our customers.

Q2: How to start orders or make payments?
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by usd,usdt，alipay ,wechat pay and cash etc.

Q3: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q4: What's your MOQ?
A:Our MOQ is 100g. 

Q5: How about delivery lead time?
A:Delivery lead time: About 15 days after payment confirmed. (Chinese holiday not included)