Mearnsitrin 98% Purity CAS 30484-88-9 Flavonoid Glycoside for Antidiabetic and Antioxidant Research Reagent Grade

• • • • • • • • • • • • • • • • • • Product Overview

                                    Mearnsitrin, also known as Mearnsetin 3-rhamnoside or Myricetin 4'-methyl ether-3-O-rhamnoside, is a naturally occurring flavonol glycoside compound first isolated from the leaves of Myrcia multiflora DC. It is also found in other plants including Syzygium samarangense and Acacia mearnsii. Structurally, it consists of the aglycone myricetin 4'-methyl ether linked to an L-rhamnose sugar moiety at the 3-position. This product is a high-purity research-grade reagent with a purity of ≥98% as determined by HPLC analysis, appearing as a solid powder. It is primarily used in antidiabetic research, natural product chemistry, and antioxidant studies.

                                    Chemical Properties

                                    • Molecular Formula: C₂₂H₂₂O₁₂

                                    • Molecular Weight: 478.40 g/mol

                                    • Synonyms: Mearnsetin 3-rhamnoside; Myricetin 4'-methyl ether-3-O-rhamnoside; 2-(3,5-dihydroxy-4-methoxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one

                                    • SMILES: COC1=C(O)C=C(C=C1O)C2=C(O[C@@H]3C@HC@HC@@HC@HO3)C(=O)C4=C(C=C(C=C4O)O)O2

                                    • InChIKey: NAQNISJXKDSYJD-DHWIRCOFSA-N

                                    • Boiling Point: 861.2±65.0 °C (Predicted)

                                    • Density: 1.76±0.1 g/cm³ (Predicted)

                                    • pKa: 6.16±0.40 (Predicted)

                                    • LogP: 2.83 (Predicted)

                                    • Topological Polar Surface Area: 201.58 Ų

                                    • Hydrogen Bond Donors: 7

                                    • Hydrogen Bond Acceptors: 12

                                    • Solubility: Soluble in DMSO

                                    Natural Source

                                    Mearnsitrin is a flavonol glycoside that can be isolated from the methanolic extract of Myrcia multiflora DC leaves. It has also been reported in other organisms including Syzygium samarangense, Lysimachia nummularia, and the leaves of Acacia mearnsii.

                                    Biological Activity

                                    • Antidiabetic Activity: The methanol extract of Myrcia multiflora leaves (a traditional Brazilian natural medicine) and its ethyl acetate-soluble fraction have been used as an antidiabetic agent. Studies have shown inhibitory activity against aldose reductase and α-glucosidase, as well as suppression of serum glucose elevation in sucrose-loaded rats and alloxan-induced diabetic mice. Mearnsitrin is one of the active flavonol glycosides isolated from this extract.

                                    • Antioxidant Activity: As a flavonol glycoside with multiple hydroxyl groups, it exhibits free radical scavenging activity.

                                    • Natural Product Chemistry: Serves as a reference compound for the study of flavonol glycosides and for quality control of Myrcia multiflora extracts.

                                    Quality Specifications

                                    • Purity: ≥98.0% (determined by HPLC area normalization)

                                    • Appearance: Solid powder

                                    • Identification: Conforms to structure by NMR and Mass Spectrometry

                                    • Loss on Drying: ≤0.5%

                                    • Residue on Ignition: ≤0.1%

                                    • Heavy Metals: ≤10 ppm

                                    • Each batch is accompanied by a comprehensive Certificate of Analysis (COA).

                                    Packaging & Storage

                                    • Packaging: Available in 20mg amber glass vials for research purposes. Larger quantities such as 1g and above are available upon request.

                                    • Storage: Store powder in a tightly sealed container, protected from light, at -20°C for up to 3 years, or at 2-8°C for up to 2 years. For stock solutions, store as aliquots at -20°C for up to 1 month. Allow product to equilibrate to room temperature before opening to avoid moisture condensation.

                                    • Shelf Life: 36 months when stored under recommended conditions.

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

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