—— Product Specifications ——
| Appearance | Beige to off-white powder |
| Melting Point | 266-270°C (decomposes) |
| Boiling Point | 443.7 ± 18.0°C (Predicted) |
| Density | 1.506 ± 0.06 g/cm³ (Predicted) |
| pKa | 3.03 ± 0.10 (Predicted) |
| Solubility | Slightly soluble in DMSO, methanol |
| Storage | Sealed in dry, room temperature |
| Form | Powder |
| Color | Beige / Off-white |
| BRN | 6354 |
—— Product Detail ——
Product Overview
Product Name: Indazole-3-carboxylic Acid (1H-Indazole-3-carboxylic Acid)
CAS No.: 4498-67-3
Molecular Formula: C₈H₆N₂O₂
Molecular Weight: 162.15
EINECS No.: 224-794-5
Synonyms: 1H-Indazole-3-carboxylic Acid, 3-Carboxyindazole, Granisetron EP Impurity H, NSC-520610
Indazole-3-carboxylic Acid (CAS 4498-67-3) is a heterocyclic organic compound belonging to the indazole family. It appears as a beige to off-white powder with a molecular weight of 162.15. The compound is slightly soluble in DMSO and methanol, with a melting point of 266-270°C (dec.).
With a purity of ≥98.0% by HPLC, this compound serves as a key pharmaceutical intermediate and organic synthesis building block. The indazole core structure is a privileged scaffold in medicinal chemistry, making this compound valuable for drug discovery and development.
Key Applications:
1. Pharmaceutical Intermediates (Primary Application)
Indazole-3-carboxylic Acid is a crucial intermediate in the synthesis of Granisetron, a serotonin 5-HT₃ receptor antagonist used as an antiemetic to prevent nausea and vomiting caused by chemotherapy and radiation therapy. It is also listed as Granisetron EP Impurity H for pharmaceutical quality control.
2. Pharmaceutical Research
Indazole-3-carboxylic acid derivatives have been studied for various therapeutic applications including:
3. Organic Synthesis
Serves as a versatile building block for constructing diverse indazole-containing compounds for drug discovery, agrochemical development, and materials science.
— c ompany Profile ——
Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.
Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.
We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.
To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.
Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.
—— Q&A ——
Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.
Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.
Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.
Q4: What is your MOQ? Is there a discount?
A: For high value products, our MOQ starts from 1g and generally starts from 10g. For other low price products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.
Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly,we accept usd,.usdt，alipay，wechat pay and cash. If you have other preferred payment methods, we are open to discussion and negotiation.
