—— Product Specifications ——
| Appearance | White to off-white crystalline powder |
| Melting Point | 150-153°C (dec.) |
| Specific Rotation [α]²⁰/D | +12.0 to +14.0° (c=2, H₂O) |
| Solubility | Soluble in water (50 mg/mL), methanol (5%) |
| Storage Condition | Inert atmosphere, 2-8°C, protect from moisture |
| Sensitivity | Hygroscopic |
| Density | 0.955 g/cm³ |
| Boiling Point | 169.2°C at 760 mmHg |
—— Product Detail ——
Product Overview
Product Name: L-Leucine Methyl Ester Hydrochloride (H-Leu-OMe·HCl)
CAS No.: 7517-19-3
Molecular Formula: C₇H₁₅NO₂·HCl (or C₇H₁₆ClNO₂)
Molecular Weight: 181.66
EINECS No.: 231-375-0
Synonyms: H-Leu-OMe·HCl, Methyl L-leucinate hydrochloride, L-Leucine methyl ester HCl, (S)-2-Amino-4-methyl-pentanoic acid methyl ester hydrochloride
L-Leucine Methyl Ester Hydrochloride (CAS 7517-19-3) is a hydrochloride salt of the methyl ester derivative of L-leucine, an essential branched-chain amino acid. It appears as a white to off-white crystalline powder with a molecular weight of 181.66.
With a purity of ≥99.0% by titration, this compound serves as a versatile building block in peptide synthesis and pharmaceutical research. The methyl ester group enhances the compound's nucleophilicity, facilitating coupling reactions required to form peptides, while the hydrochloride form improves solubility and stability. This compound is slightly hygroscopic and should be stored under inert gas to prevent moisture absorption
Key Applications:
1. Pharmaceutical Intermediates
Used as an intermediate in the synthesis of various pharmaceutical compounds and active pharmaceutical ingredients (APIs). The compound serves as a protected amino acid derivative, allowing for selective reactions in multi-step organic synthesis.
2. Proteomics Research
Instrumental in proteomics research, particularly in the study of protein modifications and interactions. The esterified form allows for selective labeling of proteins, aiding in the identification and quantification of protein modifications. Its use in mass spectrometry-based proteomics enhances detection accuracy and sensitivity.
3. Metabolic Pathway Analysis
Utilized in metabolic pathway analysis to investigate the role of leucine in cellular metabolism. The compound's enhanced solubility and reactivity allow for its incorporation into metabolic assays, where it serves as a tracer or substrate.
4. Biochemical Research
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Enzymology studies and protein engineering
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Transmembrane transport studies in membrane protein analysis
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Biosynthetic research applications
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Reference standards for analytical method development
— c ompany Profile ——
Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.
Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.
We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.
To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.
Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.
—— Q&A ——
Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.
Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.
Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.
Q4: What is your MOQ? Is there a discount?
A: For high value products, our MOQ starts from 1g and generally starts from 10g. For other low price products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.
Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly,we accept usd,.usdt，alipay，wechat pay and cash. If you have other preferred payment methods, we are open to discussion and negotiation.
