—— Product Specifications ——

—— Product Detail ——

Product Overview

Product Name: 1-Hydroxybenzotriazole Hydrate (HOBt Hydrate)

CAS No.: 123333-53-9

Molecular Formula: C₆H₅N₃O·H₂O (C₆H₇N₃O₂)

Molecular Weight: 153.14 

EINECS No.: 219-989-7 

Synonyms: 1H-Benzotriazol-1-ol Hydrate, HOBt Hydrate, HOBt H₂O, N-Hydroxybenzotriazole Hydrate, 1-Hydroxy-1H-benzotriazole Hydrate

1-Hydroxybenzotriazole Hydrate (CAS 123333-53-9), commonly known as HOBt Hydrate, is a white to off-white crystalline powder with a molecular weight of 153.14. It is a widely used coupling reagent and additive in peptide and oligonucleotide synthesis. 

With a purity of ≥99.0% by HPLC, this compound plays a critical role in suppressing racemization during peptide coupling reactions, enhancing reaction efficiency, and improving yields in amide bond formation. It is slightly soluble in water and soluble in DMF, making it suitable for various organic synthesis applications.

Key Applications:

1. Pharmaceutical Intermediate

Serves as a key reagent in the synthesis of various pharmaceutical compounds, including poly-γ-glutamic acid derivatives and oxadiazoles via cyclocondensation reactions. 

2. Biochemical Research

Used in the synthesis of amides through condensation reactions between activated esters/acids and amino groups, making it invaluable for drug development and biomolecule research. 

3. Corrosion Inhibition & UV Stabilization

The benzotriazole core provides effective corrosion inhibition properties and UV stabilization for coatings, plastics, and other industrial materials.

— c ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly,we accept usd,.usdt，alipay，wechat pay and cash. If you have other preferred payment methods, we are open to discussion and negotiation.