Product Overview

Benzoic anhydride is an organic compound with the molecular formula C₁₄H₁₀O₃ and molecular weight of 226.23 g/mol. This white to off-white crystalline solid is a valuable acylating agent and intermediate in pharmaceutical, dye, and organic synthesis research. The compound features two benzoyl groups connected by an anhydride linkage.

Synthetic Process

• Dehydration: Benzoic acid reacts with acetic anhydride in the presence of a catalyst (e.g., phosphoric acid) to form benzoic anhydride

• Purification: The crude product is purified by vacuum distillation and recrystallization

• Quality Control: The final product is analyzed to ensure ≥98.0% purity by GC

Mechanism of Action

• Acylating Agent: The anhydride group reacts with nucleophiles (amines, alcohols) to form amides and esters

• Water Detection: Used as a reagent for the determination of water in organic liquids

• Friedel-Crafts Acylation: Used for the introduction of benzoyl groups onto aromatic rings

Research Applications & Market Significance

• Pharmaceutical Research: Building block for drug discovery programs and pharmaceutical intermediates

• Organic Synthesis: Key reagent for benzoylation reactions

• Dye Industry: Intermediate for the preparation of dyes and pigments

• Analytical Chemistry: Used for the determination of water content in organic solvents

Quality Specifications

• Purity: ≥98.0% determined by GC

• Melting point: 38-42°C

• Boiling point: 360°C

• Density: 1.199 g/mL at 25°C

• Loss on drying: ≤0.5%

• Storage: 2-8°C, sealed, protected from moisture

• Stable for 36 months when properly stored

Packaging & Shipping

• Research quantities: 25g, 100g amber glass bottles

• Bulk quantities: 500g, 1kg amber glass bottles

• Shipped at ambient temperature