—— Product Specifications ——
Parameter | Specification | Details / Test Method |
Purity（HPLC） | ≥98% | Standard test method for purity（hplc） |
Appearance | Grey powder | Visual inspection at room temperature |
Molecular Weight | 405.45 g/mol | Calculated from molecular formula |
CAS Number | 1391426-24-6 | Verified by supplier documentation |
Loss on Drying | <5% | Gravimetric method, 105°C for 2 hours |
Heavy Metals | <10 ppm | ICP-MS method, max 10 ppm as Pb |
Residual Solvents | ICH compliant | Headspace GC-MS method, ICH Q3C guidelines |
Identity | Confirmed by NMR and MS | IR spectrum / NMR spectrum comparison |
Storage Temperature | -20°C | Standard test method for storage temperature |
Shelf Life | 2 years | 24 months from date of manufacture under proper storage |
Solubility | DMSO, methanol | Tested in various solvents at 25°C |
Optical Rotation | N/A | Standard test method for optical rotation |
—— Product Detail ——
Product Overview
Lys05 is a potent and selective inhibitor of Lysyl-tRNA synthetase (LysRS), a key enzyme in protein synthesis. This compound specifically targets the LysRS enzyme, which plays a crucial role in charging tRNA molecules with lysine during translation. Lys05 has gained significant attention in cancer research due to its ability to modulate the mTOR signaling pathway and regulate autophagy processes. The compound has demonstrated potential in preclinical studies for various therapeutic applications, particularly in oncology. As a research-grade biochemical reagent, Lys05 is primarily used in laboratory settings for target validation, mechanism of action studies, and drug discovery programs. The high purity grade ensures reliable and reproducible results in sensitive biochemical assays.
Synthesis Process
Lys05 is synthesized through a multi-step organic synthesis process involving Buchwald-Hartwig amination reactions and subsequent functional group transformations. The process typically begins with appropriate aromatic or heterocyclic building blocks, which undergo cross-coupling reactions to form the core scaffold. Key steps include palladium-catalyzed C-N bond formation, followed by deprotection and purification via chromatography. The final product is rigorously purified to achieve 98% purity and characterized using analytical techniques including HPLC, NMR, and mass spectrometry.
Quality Specifications
The product meets the following specifications: purity ≥98% as determined by HPLC, moisture content <5%, residual solvents within ICH guidelines, heavy metals <10ppm. Each batch is accompanied by a Certificate of Analysis (CoA) detailing all test results. The compound is tested for identity confirmation, purity verification, and absence of known impurities.
Packaging & Storage
Lys05 is packaged in amber glass vials with screw caps, sealed with induction innermost layer. Each container is labeled with product name, CAS number, purity, batch number, and net weight. Storage conditions: maintain at -20°C in a dry, dark environment. Keep container tightly closed when not in use. Transport under cold chain conditions to preserve stability. Handle in accordance with good laboratory practices.
—— C ompany Profile ——
Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.
Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.
We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.
To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.
Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.
—— Q&A ——
Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.
Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.
Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.
Q4: What is your MOQ? Is there a discount?
A: For high value products, our MOQ starts from 1g and generally starts from 10g. For other low price products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.
Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.
