ACBI1 | CAS 2375564-55-7 | 98% Purity | PROTAC Degrader | For Cancer Research & Drug Discovery

1. Product Overview

ACBI1 (CAS No. 2375564-55-7) is a potent, structure-based PROTAC (Proteolysis Targeting Chimera) degrader specifically designed to target the BAF (Brg1/Brahma-associated factors) chromatin remodeling complex. Composed of a bromodomain ligand, a tailored linker, and the E3 ubiquitin ligase VHL (von Hippel-Lindau) ligand, ACBI1 induces the selective degradation of BAF ATPase subunits and PBAF complex members, offering a powerful chemical tool for chromatin biology and oncology research.

2. Key Features and Advantages

• High Potency: Exhibits DC50 values of 6 nM for SMARCA2, 11 nM for SMARCA4, and 32 nM for PBRM1 in MV-4-11 cells.

• Structure-Based Design: Engineered through rational structure-based PROTAC design, ensuring precise target engagement.

• Multi-Target Degradation: Simultaneously degrades SMARCA2, SMARCA4, and PBRM1, enabling comprehensive BAF complex disruption.

• Proven Biological Activity: Demonstrated anti-proliferative effects and induction of apoptosis in cancer cell lines.

• Research-Grade Quality: Typically ≥98% purity (HPLC), suitable for biochemical assays and cellular studies.

3. Main Applications

• Cancer Research: Investigating BAF complex vulnerabilities in malignancies, particularly in acute myeloid leukemia (AML) and other cancers dependent on BAF ATPases.

• Epigenetics & Chromatin Biology: Studying the role of SWI/SNF chromatin remodelers in gene regulation.

• PROTAC Technology Development: Serving as a reference PROTAC molecule for degrader design and optimization.

• Drug Discovery: Providing a chemical probe for target validation and lead optimization in BAF-targeted therapeutics.

4. Technical Specifications

5. Storage and Handling

• Short-term Storage: Store at -20°C in a sealed container, protected from light and moisture.

• Long-term Storage: Recommended at -20°C or below; avoid repeated freeze-thaw cycles.

• Handling: Allow the product to equilibrate to room temperature before opening. Use under a dry, inert atmosphere when possible. Dissolve in appropriate solvents (DMSO recommended for stock solutions) immediately before use.

6. Safety Overview

• Hazard Classification: Irritant (Xi) — handle with appropriate personal protective equipment (PPE).

• Precautions: Wear protective gloves, safety goggles, and a lab coat. Avoid inhalation, contact with skin, and ingestion.

• Disposal: Dispose of in accordance with local regulations for chemical waste. Do not discharge into drains or the environment.

• Intended Use: For laboratory research use only. Not for human consumption, clinical use, or therapeutic applications.