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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Niraparib tosylate for Sale > Niraparib Tosylate Monohydrate CAS 1613220-15-7 Selective PARP1/2 Inhibitor for Ovarian Cancer Research hfd
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Niraparib Tosylate Monohydrate CAS 1613220-15-7 Selective PARP1/2 Inhibitor for Ovarian Cancer Research hfd

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Unit Price:

$100-130/G FOB

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CAS No.:

1613220-15-7

Grade:

Reagent Grade

Content:

99%

Port:

qingdao

Brand:

//

Packaging:

5g, 25g, 100g, 500g

Price valid (until):

2026-09-27

Company Type:
Trader
Location:
China
Qualification:
Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    —— Product Specification ——

    Parameter Specification Details
    Product Name Niraparib Tosylate Monohydrate Zejula; MK-4827
    CAS Number 1613220-15-7 1613220-15-7
    Molecular Formula C₂₆H₃₀N₄O₅S C₁₉H₂₀N₄O·C₇H₈O₃S·H₂O 
    Molecular Weight 510.61 g/mol
    Appearance White to off-white crystalline solid Visual inspection
    Purity ≥98.0% Determined by HPLC 
    IC₅₀ (PARP1) 3.8 nM Potent PARP1 inhibition 
    IC₅₀ (PARP2) 2.1 nM Potent PARP2 inhibition 
    IC₅₀ (PARP3) 1300 nM >100-fold selectivity over PARP3 
    IC₅₀ (Tankyrase-1) 570 nM High selectivity over tankyrase 
    Solubility DMSO: 247.5 mg/mL (484.7 mM); H₂O: 1 mg/mL (1.96 mM)
    IUPAC Name 4-methylbenzenesulfonic acid; 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide; hydrate
    Storage Powder: -20°C for 3 years; In solvent: -80°C for 1 year Sealed containers, protect from moisture and light 
    Packaging 10mg, 25mg, 50mg, 100mg, 500mg, 1g Amber glass vials
    Application Research use only Oncology research, PARP inhibition studies


    —— Product Detail ——

    Product Overview

    • Niraparib Tosylate Monohydrate (CAS 1613220-15-7) is the tosylate salt monohydrate form of niraparib, an orally bioavailable, potent, and selective inhibitor of poly(ADP-ribose) polymerase (PARP) enzymes, specifically targeting PARP-1 and PARP-2 . It appears as a white to off-white crystalline solid with the molecular formula C₂₆H₃₀N₄O₅S and a molecular weight of 510.61 g/mol . The compound is marketed under the brand name Zejula  and was approved by the FDA in 2017 for the treatment of ovarian cancer.


    Packaging & Shipping

                  • Research quantities: 5mg, 10mg, 25mg amber glass vials

                  • Bulk quantities: 50mg, 100mg amber glass bottles

                  • Custom packaging available upon request

                  • Not classified as hazardous material for transport under normal conditions

                  • Product for research and analytical use only; not for human therapeutic use

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    Company profile ——


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    Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

    Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

    We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

    To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

    Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

     

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    —— Q&A ——

    Q1: How to confirm the product quality before placing orders?
    A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

    Q2: Can you supply free samples?
    A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

    Q3: How do you treat quality complaints?
    A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

    Q4: What is your MOQ? Is there a discount?
    A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
    Q: Is there a discount?
    A: Yes, for larger quantities, we always support with better prices.

    Q5: How to start orders or make payments?
    A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.



    ECHEMI Editorial Reference
    Niraparib Tosylate Monohydrate is an orally bioavailable, hydrated, tosylate salt form of niraparib, an inhibitor of poly (ADP-ribose) polymerase (PARP) types 1 and 2 (PARP-1 and -2), with antineoplastic activity. Upon administration, niraparib binds to and inhibits the activity of PARP-1 and -2, thereby inhibiting PARP-1 and -2-mediated DNA repair, enhancing the accumulation of DNA strand breaks, promoting genomic instability and resulting in apoptosis. The PARP family of proteins catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks.

    Certificates
    • Niraparib Tosylate Monohydrate CAS 1613220-15-7 Selective PARP1/2 Inhibitor for Ovarian Cancer Research hfd Certificates 1 TDS

    Basic Info
    Product Name:

    Niraparib tosylate

    Other Name:

    MK-4827, Niraparib TsOH salt hydrate

    CAS No.:

    1613220-15-7

    Molecular Formula:

    C26H30N4O5S

    InChIKeys:

    ACNPUCQQZDAPJH-FMOMHUKBSA-N

    Molecular Weight:

    510.6052

    Exact Mass:

    510.193695

    UNII:

    195Q483UZD

    NCI Thesaurus Code:

    C133238

    Characteristics
    PSA:

    135.69

    XLogP3:

    5.943

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

    Location:

    RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

    Payment Terms:

    TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    11-50

    Year of Establishment:

    2022

    Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
  • Inquiry History
    1 Inquiries
    Country Product Purchase Quantity Date Posted
    United States

    Niraparib toysylate

    5 G Feb 15, 2025
    Post an enquiry for this product
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