—— Product Specification ——
| Parameter | Specification | Details |
| Product Name | 6-(2-Chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole | Abemaciclib Impurity 3, LY2835219 Intermediate |
| CAS Number | 1231930-42-9 | 1231930-42-9 |
| Molecular Formula | C₁₅H₁₃ClF₂N₄ | 15 carbons, 13 hydrogens, 1 chlorine, 2 fluorine, 4 nitrogens |
| Molecular Weight | 322.74 g/mol | — |
| Appearance | Off-white to light yellow solid | Visual inspection |
| Purity | ≥98.0% | Determined by HPLC |
| Boiling Point | 509.6±45.0°C (Predicted) | — |
| Density | 1.42±0.1 g/cm³ (Predicted) | — |
| pKa | 2.32±0.10 (Predicted) | — |
| Storage | Inert atmosphere, 2-8°C | Sealed containers, protect from moisture |
| Packaging | 1g, 5g, 10g, 25g, 100g | Amber glass vials |
| Application | Research use only | Pharmaceutical intermediate, impurity reference standard |
—— Product Detail ——
Product Overview
6-(2-Chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole (CAS 1231930-42-9) is a key pharmaceutical intermediate and impurity reference standard in the synthesis of Abemaciclib (LY2835219, Verzenio), a selective CDK4/6 inhibitor used for the treatment of hormone receptor-positive, HER2-negative breast cancer. The compound appears as an off-white to light yellow solid with the molecular formula C₁₅H₁₃ClF₂N₄ and a molecular weight of 322.74 g/mol .
With a purity of ≥98.0% by HPLC, this compound serves as a critical building block (LY2835219 intermediate) in the industrial synthesis of Abemaciclib. It is also widely used as Abemaciclib Impurity 3 for analytical method development, method validation (AMV), and quality control (QC) applications in abbreviated new drug applications (ANDA)
Packaging & Shipping
-
-
-
-
-
-
-
-
Research quantities: 1g, 5g, 10g amber glass vials
-
Bulk quantities: 25g, 100g amber glass bottles
-
Custom packaging available upon request
-
Not classified as hazardous material for transport
-
Product for analytical and research use only; not for human or veterinary use
— Company profile ——
Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.
Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.
We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.
To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.
Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.
—— Q&A ——
Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.
Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.
Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.
Q4: What is your MOQ? Is there a discount?
A: For high value products, our MOQ starts from 1g and generally starts from 10g. For other low price products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.
Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.
